Drug

D0370 | Mito-4509

Molecular Formula C18H24O2
Molecular Weight 272.4
Structure
State solid
Description a non-feminizing estrogen analog that could affect mitochondrial metabolic pathways

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 37.81±13.89 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 22.39 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 35.48±0.00 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 153 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 3 of 153 companies. For more detailed information, please visit ECHA C&L website


Of the 7 notification(s) provided by 150 of 153 companies with hazard statement code(s):


H302 (11.33%): Harmful if swallowed [Warning Acute toxicity, oral]


H312 (10.67%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H332 (10.67%): Harmful if inhaled [Warning Acute toxicity, inhalation]


H351 (98.67%): Suspected of causing cancer [Warning Carcinogenicity]


H360 (62%): May damage fertility or the unborn child [Danger Reproductive toxicity]


H361 (45.33%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H362 (57.33%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (17?)-Estra-1,3,5(10)-triene-3,17-diol (17alpha)-estra-1,3,5(10)-triene-3,17-diol (1S,10R,11S,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol
    (8R,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol (8R,9S,13S,14S,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 064E144
    1,3,5-Estratriene-3,17-alpha-diol 1,3,5-Estratriene-3,17.alpha.-diol 1,3,5-Estratriene-3,17a-diol
    1,5-Estratriene-3,17.alpha.-diol 13b-Methyl-1,3,5(10)-gonatriene-3,17a-diol 13beta-methyl-1,3,5(10)-gonatrien-3,17alpha-diol
    17 alpha-estradiol 17-Epiestradiol 17-alpha-Estradiol
    17-alpha-Estradiol 100 microg/mL in Acetonitrile 17-epi-Estradiol 17-epi-Estradiol)
    17.alpha.-Estradiol 17.alpha.-Oestradiol 17a-Oestradiol
    17a-estradiol 17alpha estradiol 17alpha-Estradiol
    17alpha-Estradiol (17-epi-Estradiol 17|A-estradiol 23E54080-77C2-4457-A388-FCBCE0B68C38
    3,17-Dihydroxyestratriene 3,17-alpha-Dihydroxyoestra-1,3,5(10)-triene 3,17.alpha.-Dihydroxyestra-1,3,5(10)-triene
    3,17.alpha.-Dihydroxyoestra-1,3,5(10)-triene 3,17a-Dihydroxyestra-1,3,5(10)-triene 3,17a-Dihydroxyoestra-1,3,5(10)-triene
    3,17alpha-Dihydroxyestra-1,3,5(10)-triene 3,17alpha-Dihydroxyoestra-1,3,5(10)-triene 3,3,5(10)-triene
    3VQ38D63M7 4-06-00-06611 (Beilstein Handbook Reference) 57-91-0
    ABP-150 AC-2168 AKOS024457306
    Alfatradiol Alfatradiol (INN) Alfatradiol [INN]
    B7201 BDBM20624 BIDD:ER0163
    BRN 2698044 C02537 C18H24O2
    CAS-57-91-0 CCRIS 7203 CHEBI:17160
    CHEMBL286452 CS-0014231 CTK8G3930
    D07121 DSSTox_CID_2377 DSSTox_GSID_22377
    DSSTox_RID_76564 DTXSID8022377 E0919
    EINECS 200-354-8 Epiestradial Epiestradiol
    Epiestrol Estra-1,3,5(10)-triene-3,17-diol, (17-alpha)- Estra-1,3,5(10)-triene-3,17-diol, (17a)-
    Estra-1,3,5(10)-triene-3,17.alpha.-diol Estra-1,3,5(10)-triene-3,17a-diol Estra-1,3,5(10)-triene-3,17alpha-diol
    Estra-1,3,5(10)-triene-3,17alpha-diol (17alpha-Estradiol Estra-1,3,5(10)-triene-3,17alpha-diol) Estra-1,5(10)-triene-3,17-diol, (17.alpha.)-
    Estra-1,5(10)-triene-3,17.alpha.-diol Estradiol, 17.alpha.- Estradiol, 17alpha-
    Estradiol-17alpha Estradiol-17|A GS-5672
    HY-B0141A KBio2_002281 KBio2_004849
    KBio2_007417 KBio3_002761 KBioGR_002281
    KBioSS_002282 LMST02010029 MITO-4509
    MX-4509 NCGC00161666-01 NCGC00161666-02
    NCGC00161666-03 NCGC00161666-04 NCGC00256569-01
    NCGC00258814-01 NSC 20293 NSC-20293
    NSC20293 Oestra-1,3,5(10)-triene-3,17.alpha.-diol Oestra-1,3,5(10)-triene-3,17a-diol
    Oestra-1,3,5(10)-triene-3,17alpha-diol Oestra-1,5(10)-triene-3,17.alpha.-diol Oestradiol-17-alpha
    Oestradiol-17.alpha. Oestradiol-17alpha Q4721888
    SC-81163 SCHEMBL121568 Tox21_201262
    Tox21_303644 UNII-3VQ38D63M7 UPCMLD-DP131
    UPCMLD-DP131:001 VOXZDWNPVJITMN-SFFUCWETSA-N WLN: L E5 B666TTT&J E1 FQ OQ 17-ALPHA
    ZINC3815415 a-Estradiol alpha-Estradiol
    alpha-Estradiol, 98% alpha-Estradiol, VETRANAL(TM), analytical standard alpha-Estradiol, powder, >=98% (TLC)
    cMAP_000011

    DrugBank Name Mito-4509
    DrugBank DB05846
    CAS Number 50-28-2, 57-91-0, 5962-42-5
    PubChem Compound 68570
    KEGG Compound ID C02537
    KEGG Drug D07121
    PubChem.Substance 347910266
    ChEBI 17160
    ChemSpider 61840
    Wikipedia 17alpha-Estradiol