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Drug

D0376 | Nitazoxanide

Molecular Formula C12H9N3O5S
Molecular Weight 307.28
Structure
State solid
Clearance Nitazoxanide is cleared in the urine and feces. The metabolite, tizoxanide, is also found in the urine, plasma, and breastmilk [L1424]. The drug is not found unchanged in the urine [L1424].
Route of elimination Tizoxanide is excreted in the urine, bile and feces, and tizoxanide glucuronide is excreted in urine and bile. Approximately 2/3 of the oral dose of nitazoxanide is excreted in the faeces and 1/3 in the urine [FDA label, A31981].
Protein binding Very High (greater than 99%), bound to proteins in the plasma [FDA label, A31981].
Half life 7.3h [L1422]
Absorption The relative bioavailability of the suspension compared to the tablet was 70%. When administered with food the AUC and C<sub>max</sub> increased by two-fold and 50%, respectively, for the tablet and 45 to 50% and &le; 10%, respectively, for the oral suspension [FDA label].

P

P01AX11 Nitazoxanide


[P01AX] Other agents against amoebiasis and other protozoal diseases


[P01A] AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES


[P01] ANTIPROTOZOALS


[P] Antiparasitic products, insecticides and repellents

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 1.04±0.96 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 1.26 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 6.94±4.36 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 2 of 44 companies. For more detailed information, please visit ECHA C&L website


Of the 3 notification(s) provided by 42 of 44 companies with hazard statement code(s):


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (97.62%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Diarrhoea

  • Immunodeficiency

  • Vomiting (0.00011)

  • Abdominal pain

  • Diarrhoea

  • Gastrointestinal pain

  • Headache

  • Nausea

    • (2-((5-Nitro-2-thiazolyl)carbamoyl)phenyl)acetat 2-((5-nitrothiazol-2-yl)carbamoyl)phenyl acetate 2-(5-nitrothiazol-2-ylcarbamoyl)phenyl acetate
    2-(Acetolyloxy)-N-(5-nitro-2-thiazolyl)benzamide 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
    2-Acetyloxy-N-[(5-nitro-2-thiazolyl)]benzamide 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate 2-[N-(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
    4CH-006389 55981-09-4 981N094
    A830877 AB0010620 AB00639988-07
    AB00639988-09 AB00639988_10 AB00639988_11
    AB2000173 AC-1302 AK-26130
    AKOS015915393 API0015832 AX8040854
    AZT + Nitazoxanide Adrovet Alinia
    Alinia (TN) Alinia(TM) BCP13918
    BDBM50075050 BG0652 BR-26130
    BRN 1225475 Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)- C-23836
    C12H9N3O5S CAS-55981-09-4 CC-32885
    CCG-35851 CHEBI:94807 CHEMBL1401
    CN0040 CPD000466367 Colufase
    Cryptaz D02486 DB00507
    DSSTox_CID_13757 DSSTox_GSID_33757 DSSTox_RID_79095
    DTXSID5033757 Daxon Dexidex
    EINECS 259-931-8 EN300-220095 FT-0082459
    FT-0601547 HMS2051L04 HMS3393L04
    HMS3655M11 HMS3715F10 HY-B0217
    Heliton J10428 KS-00000VRX
    KS-1160 Kidonax LS-144176
    MCULE-8701444531 MFCD00416599 MLS000759492
    MLS001424074 MLS006010127 MMV688991
    N-(5-Nitro-2-thiazolyl)salicylamide acetate (ester) N-(5-Nitrothiazol-2-yl)salicylamide acetate ester N1031
    NC00246 NCGC00090774-01 NCGC00090774-02
    NCGC00090774-03 NCGC00090774-04 NCGC00090774-05
    NCGC00258778-01 NCI60_034935 NCIMech_000843
    NITAZOXANIDE NSC 697855 NSC-697855
    NSC-760057 NSC697855 NSC760057
    NTZ NTZ NTZ;NSC 697855
    Nitax Nitaxozanid Nitaxozanide
    Nitazox Nitazoxamide Nitazoxanid
    Nitazoxanida Nitazoxanida [INN-Spanish] Nitazoxanide (Alinia, Annita)
    Nitazoxanide (USAN/INN) Nitazoxanide [USAN:INN:BAN] Nitazoxanide [USAN:INN]
    Nitazoxanide(Alinia) Nitazoxanide, >=98% (HPLC) Nitazoxanide, United States Pharmacopeia (USP) Reference Standard
    Nitazoxanidum Nitazoxanidum [INN-Latin] Nodik
    Omniparax Oprea1_263587 PH 5776
    PH-5776 Pacovanton Paramix
    Pharmakon1600-01503843 Phavic-1 Q-201475
    Q2943789 S-3645 S1627
    SAM001246708 SCHEMBL40981 SMR000466367
    SOA12P041N ST2409239 ST51059722
    STK395664 SW197626-2 Salicylamide, N-(5-nitro-2-thiazolyl)- acetate (ester)
    Salicylamide, N-(5-nitro-2-thiazolyl)-, acetate (ester) Taenitaz Tox21_111018
    Tox21_111018_1 Tox21_201226 Toza
    UNII-SOA12P041N Z1514087129 ZINC3956788
    Zox [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] ethanoate
    [2-[(5-nitrothiazol-2-yl)carbamoyl]phenyl] acetate acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester o-(N-(5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate

    DrugBank Name Nitazoxanide
    DrugBank DB00507
    CAS Number 55981-09-4
    PubChem Compound 41684
    KEGG Drug D02486
    PubChem.Substance 46507813
    ChEBI 94807
    PharmGKB PA164754874
    ChemSpider 38037
    BindingDB 50075050.0
    TTD DAP001293
    Wikipedia Nitazoxanide
    HET NTI