MITOTOX

Drug

D0411 | Tyrothricin

Molecular Formula	C65H85N11O13
Molecular Weight	1228.4
Structure
State	solid
Absorption	The lack of water solubility prevents absorption of tyrothricin through the skin. It is not used through other routes due to toxicity concerns [A32843].

S01AA05 Tyrothricin

[S01AA] Antibiotics

[S01A] ANTIINFECTIVES

[S01] OPHTHALMOLOGICALS

[S] Sensory organs

R02AB02 Tyrothricin

[R02AB] Antibiotics

[R02A] THROAT PREPARATIONS

[R02] THROAT PREPARATIONS

[R] Respiratory system

D06AX08 Tyrothricin

[D06AX] Other antibiotics for topical use

[D06A] ANTIBIOTICS FOR TOPICAL USE

[D06] ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE

[D] Dermatological drugs

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	0.24±0.05	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	0.24	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	0.66±0.39	rat	hepatocytes	MMP assay	decrease	IC50	163

1404-88-2	3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-oxo-ethyl)-9-(3-aminopropyl)-3,22,25-tribenzyl-15-[(4-hydroxyphenyl)methyl]-6-isobutyl-12-isopropyl-2,5,8,11,14,18,21,24,27-nonaoxo-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid	877376V2XW
An antibacterial substance produced by the growth of Bacillus brevis Dubos (Fam. Bacteriaceae)	Bactratycin	Biothricin
CHEMBL577736	Caswell No. 900A	Coltirot
Cyclic (-Val-Orn-Leu-D-Phe-Pro-Phe-D-Phe-Asn-Glu-Tyr-) Tyrocidine A & (HCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH2CH2OH, ILe-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH2CH2OH) Gramicidin A	Dermotricine	Dubos crude crystals
EINECS 215-771-0	EPA Pesticide Chemical Code 006311	Ginotricina
Gramicidin A & Tyrocidine A	Hydrotricine	Intraderm tyrothricin
LS-158334	Martricin	Pharothricetten
Rinotricina	Solutricine	Tirotricina
Tirotricina [INN-Spanish]	Triciderm	Tyrex
Tyri 10	Tyroderm	Tyrosur
Tyrothricin [INN:BAN]	Tyrothricin [USP:INN:BAN]	Tyrothricine
Tyrothricine [INN-French]	Tyrothricinum	Tyrothricinum [INN-Latin]
Tyrozets	UNII-877376V2XW	tyrothricin