MITOTOX

Drug

D0424 | 2-Deoxy-D-glucose

Molecular Formula	C6H12O5
Molecular Weight	164.16
Structure
State	solid
Description	glucose molecule which 2-hydroxyl group replaced by hydrogen, and cannot undergo further glycolysis.

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
OXYGEN CONSUMPTION RATE (OCR)	150 mM	2 minutes	human	HepG2	Measurement of OCR	increase	EC50	7
GLYCOLYSIS			human	SkBr3 breast cancer cells	MTT assay	decrease		25
GLYCOLYSIS						decrease		35
GLYCOLYSIS								249
ECAR	150 mM	2 minutes	human	HepG2	Measurement of ECAR	decrease	EC50	7

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Hexokinase-1						inhibit		249

(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal	154-17-6	2 Deoxy D glucose
2 Deoxyglucose	2 Desoxy D glucose	2-DEOXYLGLUCOSE
2-DG	2-Deoxy-D-arabinohexose	2-Deoxy-D-glucose, >=98% (GC), crystalline
2-Deoxy-D-glucose, >=99% (GC), crystalline	2-Deoxy-D-glucose, BioXtra, >=98%	2-Deoxy-D-glucose, United States Pharmacopeia (USP) Reference Standard
2-Deoxy-D-mannose	2-Desoxy-D-glucose	4-01-00-04282 (Beilstein Handbook Reference)
54D176	5CFA0332-FB70-485D-A064-6C4C39E7CBA1	9G2MP84A8W
AB0012037	AK-44445	AKOS015919409
AKOS015924825	ALBB-022735	ANW-21488
AS-12502	AX8002991	BR-44445
C-04435	CC-10393	CD0012
CHEMBL2074932	CTK0H5957	D-2dGlc
D-Arabino-hexose, 2-deoxy-	D-Glucose, 2-deoxy-	D-arabino-2-desoxyhexose
D-arabino-Hexose, 2-deoxy- (6CI,8CI,9CI)	D0051	DB-024740
DB08831	Deoxyglucose	FT-0601010
HSDB 5484	KS-00000K8L	KSC175S5P
LS30109	Q3266534	RTC-030040
S-1013	SC-01330	SCHEMBL7670
ST2404382	TC-030040	UNII-9G2MP84A8W
VRYALKFFQXWPIH-PBXRRBTRSA-N	ZINC2512351	arabino-Hexose, 2-deoxy-
d-2-glucodesose	deoxy-d-glucose, 2-