Drug
D0446 | phylloquinone
B
B02BA01 Phytomenadione
[B02BA] Vitamin K
[B02B] VITAMIN K AND OTHER HEMOSTATICS
[B02] ANTIHEMORRHAGICS
[B] Blood and blood forming organs
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MITOCHONDRIAL DNA METABOLIC PROCESS | >200 μM | 1 hours | human | pFastBac | Meassurement of DNA polymerase gamma activity | Negative | IC50 | 9 |
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA polymerase gamma | >200 μM | 1 hours | human | pFastBac | Meassurement of DNA polymerase gamma activity | Negative | IC50 | 9 |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
|
Aggregated GHS information provided by 49 companies from 3 notifications to the ECHA C&L Inventory. Reported as not meeting GHS hazard criteria by 17 of 49 companies. For more detailed information, please visit ECHA C&L website Of the 2 notification(s) provided by 32 of 49 companies with hazard statement code(s): H413 (96.88%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P273, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) | ||
| (E)-phytonadione | (R*,R*-(E))-(1)-2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone | 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl)- |
| 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)- | 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)- | 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, (R-(R*,R*-(E)))- |
| 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*,R*-(E)]]- | 1,4-Naphthoquinone, 2-methyl-3-phytyl- | 11104-38-4 |
| 2', 3'-trans-Vitamin K1 | 2-METHYL-3-PHYTYL-1,4-NAPHTHOQUINONE | 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalened- ione |
| 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione | 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone | 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone # |
| 2-Methyl-3-phytyl-1,4-naphthochinon | 2-Methyl-3-phytyl-1,4-naphthochinon [German] | 2-Methyl-3-phytyl-1,4-naphthoquinone |
| 2-methyl-3-((7R,11R,E)-3,7,11,15-tetramethylhexadec | 2-methyl-3-((7R,11R,E)-3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione | 2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione |
| 2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione | 2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione | 214V063 |
| 3-Phytylmenadione | 79083-00-4 | 84-80-0 |
| 84C51B31-3CE2-476B-BE66-A84BDD46A513 | A-8090 | A840928 |
| AB00698065_04 | AKOS015841892 | AS-13734 |
| AT-6461 | Antihemorrhagic vitamin | BDBM24782 |
| BIDD:GT0793 | C31H46O2 | C31H46O2 (2-methyl-3-phytyl-1,4-naphthoquinone) |
| CAS-84-80-0 | CCG-213568 | CHEBI:18067 |
| CHEMBL1550 | CS-6376 | Certified Reference Material |
| DB01022 | DSSTox_CID_3472 | DSSTox_GSID_23472 |
| DSSTox_RID_77041 | DTXSID8023472 | EBD2157931 |
| EINECS 201-564-2 | EINECS 234-330-3 | EINECS 279-052-3 |
| Fitomenadiona | Fitomenadiona [INN-Spanish] | Fitomenadione |
| Fitomenadione [DCIT] | HMS2094G09 | HMS2270J10 |
| HSDB 3162 | HY-N0684 | J10207 |
| K516 | LMPR02030028 | MBWXNTAXLNYFJB-NKFFZRIASA-N |
| MFCD00214063 | MLS001074732 | NCGC00159423-02 |
| NCGC00159423-03 | NSC 270681 | NSC-270681 |
| NSC-760373 | NSC760373 | Pharmakon1600-01505485 |
| Phyllochinon | Phyllochinon [German] | Phyllochinonum |
| Phylloquinone | Phylloquinone (8CI) | Phylloquinone (K1), analytical standard |
| Phylloquinone e-form | Phythyl-menadion (GERMAN) | Phytomenadione |
| Phytomenadione, European Pharmacopoeia (EP) Reference Standard | Phytomenadionum | Phytomenadionum [INN-Latin] |
| Phytonadione [USP:JAN] | Phytonadione, (E)-(+/-)- | Phytonadione, K1 |
| Phytonadione, Pharmaceutical Secondary Standard | Phytonadione, United States Pharmacopeia (USP) Reference Standard | Phytonadionum |
| Phytylmenadione | Q-201934 | Q186093 |
| S5Z3U87QHF | SBI-0206926.P001 | SC-13299 |
| SCHEMBL351365 | SCHEMBL3882 | SMR000112043 |
| SR-05000001941 | SR-05000001941-1 | TR-026208 |
| Tox21_111655 | Tox21_111655_1 | UNII-A034SE7857 component MBWXNTAXLNYFJB-NKFFZRIASA-N |
| UNII-MLF3D1712D component MBWXNTAXLNYFJB-NKFFZRIASA-N | UNII-S5Z3U87QHF | VITAMIN K |
| VITAMIN K1 | Vitamin K 1 | Vitamin K1 |
| Vitamin K1 (VAN) | Vitamin K1 (generic) | Vitamin K1 ,(S) |
| Vitamin K1 solution, 10 mug/mL in ethanol, certified reference material | Vitamin K1, BioXtra, >=99.0% (sum of isomers, HPLC), mixtur of isomers | Vitamin K1, viscous liquid |
| Vitamin K1-13C6 solution, 5 mug/mL in ethanol, certified reference material, ampule of 1 mL; | VitaminK1 | W-108488 |
| ZINC3831332 | [r-[r*,R*-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-napthalenedione | [r-[r*,R*-(E)]]-2-Methyl-3-(3-7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione |
| alpha-Phylloquinone | phylloquinone;2-METHYL-3-PHYTYL-1,4-NAPHTHOQUINONE | phytonadione |
| phytonadione|||trans-Phylloquinone | rel-2-Methyl-3-((7R,11R,E)-3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione | s4698 |
| trans-Phylloquinone | vitamin K hydroquinone (phylloquinone) | vitamin K1, 11 |
| DrugBank Name | phylloquinone |
| DrugBank | DB01022 |
| CAS Number | 10485-69-5, 11104-38-4, 79083-00-4, 84-80-0 |
| PubChem Compound | 5284607 |
| KEGG Compound ID | C02059 |
| ChEBI | 18067 |