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Compound

D0469 | sitaxsentan

Molecular Formula C18H15ClN2O6S2
Molecular Weight 454.9
Structure
Trade names Thelin
Description sulfonamide class endothelin receptor antagonist (ERA) ; treatment of pulmonary arterial hypertension (PAH)

C

C02KX03 Sitaxentan


[C02KX] Antihypertensives for pulmonary arterial hypertension


[C02K] OTHER ANTIHYPERTENSIVES


[C02] ANTIHYPERTENSIVES


[C] Cardiovascular system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING increase 44
ELECTRON TRANSPORT CHAIN decrease 44


  • 184036-34-8 2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thiophene-3-sulfonic acid (4-chloro-3-methyl-isoxazol-5-yl)-amide 2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thiophene-3-sulfonic acid (4-chloro-3-methyl-isoxazol-5-yl)-amide (Sitaxsentan)
    2-[2-(6-methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thiophene-3-sulfonic acid (4-chloro-3-methyl-isoxazol-5-yl) amide 210421-64-0 3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-((6-methyl-1,3-benzodioxol-5-yl)acetyl)-
    API0009258 BCP13848 BDBM50058126
    CAS-184036-34-8 CHEBI:135736 CHEMBL282724
    CS-0402 D07171 DB-065456
    DB06268 DSSTox_CID_31462 DSSTox_GSID_57673
    DSSTox_RID_97348 DTXSID0057673 FT-0701871
    GTPL3950 HY-76520 IPI 1040
    IPI-1040 J9QH779MEM N-(4-CHLORO-3-METHYLISOXAZOL-5-YL)-2-(2-(6-METHYLBENZO-[D][1,3]DIOXOL-5-YL)ACETYL)THIOPHENE-3-SULFONAMIDE;
    N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((2-methyl-4,5-methylenedioxyphenyl)acetyl)thiophene-3-sulfonamide N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((3,4-(methylenedioxy)-6-methylphenyl)acetyl)-3-thiophenesulfonamide N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((4,5-(methylenedioxy)-o-toly)acetyl)-3-thiophenesulfonamide
    N-(4-chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide N-(4-chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide. N-(4-chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-2H-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide
    N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(6-methyl-1,3-benzodioxol-5-yl) acetyl]-3-thiophenesulphonamide NCGC00253587-01 PHWXUGHIIBDVKD-UHFFFAOYSA-N
    Q905664 SB19551 SC-71670
    SCHEMBL803344 SR-01000945028 SR-01000945028-1
    Sitaxentan Sitaxentan (USAN/INN) Sitaxentan [USAN:INN]
    Sitaxsentan TBC 11251 TBC-11251
    TBC11251 / TBC-11251 Tox21_113725 UNII-J9QH779MEM
    W-5243 ZINC1481831 ZINC328577260

    CAS Number 184036-34-8, 210421-64-0, 210421-74-2, 23898-59-1
    PubChem Compound 216235
    ChEBI 135736