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Drug

D0496 | amineptine

Molecular Formula C22H27NO2
Molecular Weight 337.5
Structure
State solid
Half life 48 minutes for the parent drug and 2.5 hours for the metabolites.
Trade names Survector
Description atypical antidepressant of the tricyclic antidepressant (TCA)

N

N06AA19 Amineptine


[N06AA] Non-selective monoamine reuptake inhibitors


[N06A] ANTIDEPRESSANTS


[N06] PSYCHOANALEPTICS


[N] Nervous system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay Negative 53
ELECTROPHORETIC UNCOUPLING 278
ELECTRON TRANSPORT CHAIN rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay Negative 53
MITOCHONDRIAL FATTY ACID BETA OXIDATION decrease 54

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 oral 405mg/kg (405mg/kg) Experientia. Vol. 28, Pg. 811, 1972.


  • 10,11-dihydrodibenzo(a,d)cyclohept-5-enyl-7-aminoheptanoic acid 27T1I13L6G 3440AH
    574A091 57574-09-1 7-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)heptanoic acid
    7-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)heptanoic acid A14998 AKOS030242481
    API0008877 Amineptin Amineptine
    Amineptine (INN) Amineptine [INN] Amineptino
    Amineptino [INN-Spanish] Amineptinum Amineptinum [INN-Latin]
    BDBM50292474 BRN 2170218 CAS-57574-09-1
    CHEBI:32499 CHEMBL418995 CS-1325
    CTK5A7086 D07335 DB04836
    DSSTox_CID_28757 DSSTox_GSID_48831 DSSTox_RID_83026
    DTXSID1048831 EINECS 260-818-0 EU 1694
    FT-0662129 HEPTANOIC ACID, 7-((10,11-DIHYDRO-5H-DIBENZO(a,d)CYCLOHEPTEN-5-YL)AMINO)- HY-16044
    Heptanoic acid,7-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)amino]- LS-74382 NCGC00183843-01
    ONNOFKFOZAJDHT-UHFFFAOYSA-N Q44822059; S 1694
    SCHEMBL34086 Survector Survector (TN)
    Tox21_113313 UNII-27T1I13L6G W-5169
    ZINC2001740

    DrugBank Name amineptine
    DrugBank DB04836
    CAS Number 30272-08-3, 57574-09-1
    PubChem Compound 34870
    KEGG Drug D07335
    ChEBI 32499