A
A05AA01 Chenodeoxycholic acid
[A05AA] Bile acids and derivatives
[A05A] BILE THERAPY
[A05] BILE AND LIVER THERAPY
[A] Alimentary tract and metabolism
Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
---|---|---|---|---|---|---|---|---|
OPENING OF PERMEABILITY TRANSITION PORE (PTP) | rat | isolated liver mitochondria | increase | 55 | ||||
UNCOUPLING | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | Negative | 53 | |||
ELECTRON TRANSPORT CHAIN | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | Negative | 53 | |||
Pictogram | Signal | Statements | Precautionary Statement Codes |
---|---|---|---|
Danger |
Aggregated GHS information provided by 10 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 1 of 10 companies. For more detailed information, please visit ECHA C&L website Of the 5 notification(s) provided by 9 of 10 companies with hazard statement code(s): H302 (22.22%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (22.22%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (55.56%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (11.11%): May cause an allergic skin reaction [Warning Sensitization, Skin] H319 (55.56%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (22.22%): Harmful if inhaled [Warning Acute toxicity, inhalation] H334 (11.11%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory] H335 (22.22%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H361 (33.33%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P261, P264, P270, P271, P272, P280, P281, P285, P301+P312, P302+P352, P304+P312, P304+P340, P304+P341, P305+P351+P338, P308+P313, P312, P321, P322, P330, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) | |
(+)-chenodeoxycholate | (+)-chenodeoxycholic acid | (3a,5b,7a)-3,7-dihydroxy-cholan-24-oate |
(3a,5b,7a)-3,7-dihydroxy-cholan-24-oic acid | (3alpha,5alpha,7beta,8alpha,17alpha)-3,7-dihydroxycholan-24-oic acid | (3alpha,5beta,7alpha,8xi)-3,7-dihydroxycholan-24-oic acid |
(3beta,7beta,8xi,9xi,14xi,17alpha)-3,7-dihydroxycholan-24-oic acid | (3|A,5|A,7|A)-3,7-Dihydroxycholan-24-oic Acid | (4R)-4-((1S,2S,7S,11S,5R,9R,10R,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo [8.7.0.0<2,7>.0<11,15>]heptadec-14-yl)pentanoic acid |
(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0(2),.0(1)(1),(1)]heptadecan-14-yl]pentanoic acid | (4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0?,?.0??,??]heptadecan-14-yl]pentanoic acid; | (4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid |
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid | (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid | (S)-Chenodeoxycholic Acid |
0DBBBC66-0CFA-4DB9-97F4-5B1492756A02 | 0GEI24LG0J | 25795-EP2289883A1 |
25795-EP2295411A1 | 25795-EP2315303A1 | 3,7-Dihydroxycholan-24-oic acid, (3.alpha.,5.beta.,7.alpha.)- # |
3-alpha,7-alpha-Dihydroxy-5-beta-cholan-24-oic acid | 3-alpha,7-alpha-Dihydroxycholanic acid | 3-alpha,7-alpha-Dihydroxycholansaeure |
3-alpha,7-alpha-Dihydroxycholansaeure [German] | 3.alpha.,7.alpha.-Dihydroxy-5.beta.-cholan-24-oic acid | 3.alpha.,7.alpha.-Dihydroxy-5.beta.-cholanic acid |
3.alpha.,7.alpha.-Dihydroxy-5.beta.-cholanoic acid | 3.alpha.,7.alpha.-Dihydroxycholanic acid | 3.alpha.,7.alpha.-Dihydroxycholansaeure |
3a,7a-dihydroxy-5b,14a,17b-cholanate | 3a,7a-dihydroxy-5b,14a,17b-cholanic acid | 3a,7a-dihydroxy-5b-cholan-24-oate |
3a,7a-dihydroxy-5b-cholan-24-oic acid | 3a,7a-dihydroxy-5b-cholanate | 3a,7a-dihydroxy-5b-cholanic acid |
3alpha, 7alpha,-dihydroxy-5beta-cholanic acid | 3alpha, 7alpha-dihydroxy-5beta-cholanoic acid | 3alpha,7alpha-Dihydroxy-5beta-cholan-24-oic acid |
3alpha,7alpha-Dihydroxy-5beta-cholanic acid | 474-25-9 | 5-beta-Cholan-24-oic acid, 3-alpha,7-alpha-dihydroxy- |
5.beta.-Cholan-24-oic acid, 3.alpha.,7.alpha.-dihydroxy- | 5beta-Cholanic acid-3alpha,7alpha-diol | 7-alpha-Hydroxylithocholic acid |
7.alpha.-Hydroxylithocholic acid | 7a-Hydroxy-desoxycholsaeure | 7alpha-hydroxylithocholic acid |
AB00513822 | AB00513822-06 | AB00513822_07 |
AB2000327 | AKOS024280614 | AS-13636 |
Acide chenodeoxycholique | Acide chenodeoxycholique [INN-French] | Acido chenodeoxicholico |
Acido chenodeoxicholico [INN-Spanish] | Acidum chenodeoxycholicum | Acidum chenodeoxycholicum [INN-Latin] |
Anthropodeoxycholic acid | Anthropodesoxycholic acid | Anthropododesoxycholic acid |
BDBM21674 | BIDD:PXR0056 | BPBio1_000210 |
BRD-K18135438-001-16-7 | BSPBio_000190 | C-2900 |
C02528 | CAS-474-25-9 | CCG-220285 |
CCRIS 2195 | CHEBI:16755 | CHEMBL240597 |
CHENIX (TN) | CS-0834 | Cdca |
Chendal | Chendeoxycholic Acid | Chendol |
Chenic acid | Chenique Acid | Chenix |
Chenocedon | Chenocholic acid | Chenocol |
Chenodeoxycholate | Chenodeoxycholic acid (JP16/INN) | Chenodeoxycholic acid (JP17/INN) |
Chenodeoxycholic acid [INN] | Chenodeoxycholic acid, 500 mug/mL in methanol, certified reference material | Chenodeoxycholic acid, >=97% |
Chenodeoxycholic acid, European Pharmacopoeia (EP) Reference Standard | Chenodesoxycholic acid | Chenodesoxycholsaeure |
Chenodesoxycholsaeure [German] | Chenodex | Chenodiol |
Chenodiol (USAN) | Chenodiol [USAN] | Chenodiol;Chenodesoxycholic acid;Chenocholic acid |
Chenofalk | Chenorm | Chenossil |
Cholan-24-oic acid, 3,7-dihydroxy-, (3-.alpha., 5-.beta., 7-.alpha.)- | Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-alpha)- | Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-alpha)- (9CI) |
Cholan-24-oic acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.alpha.)- | Cholan-24-oic acid, 3,7-dihydroxy-, (3a,5b,7a)- | Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7alpha)- |
Cholanorm | D00163 | DB06777 |
DSSTox_CID_260 | DSSTox_GSID_20260 | DSSTox_RID_75469 |
DTXSID2020260 | Dihydroxy-3.alpha.,7.alpha.(5.beta.)Cholanic acid | EC 207-481-8 |
EINECS 207-481-8 | Fluibil | GTPL608 |
Gallodesoxycholic acid | HMS1568J12 | HMS2095J12 |
HMS2234I22 | HMS3712J12 | HSCI1_000210 |
HY-76847 | Hekbilin | Henohol |
J10019 | JN3 | Kebilis |
LMST04010032 | LS-7259 | Leadiant (formerly Chenodeoxycholic acid sigma-tau) |
MCULE-3421183878 | MLS002154253 | NCGC00016387-02 |
NCGC00142400-03 | NCGC00142400-04 | NCGC00258045-01 |
NSC 657949 | NSC-657949 | NSC657949 |
Prestwick0_000285 | Prestwick1_000285 | Prestwick2_000285 |
Prestwick3_000285 | Q419028 | RUDATBOHQWOJDD-BSWAIDMHSA-N |
S1843 | SBB002935 | SCHEMBL25055 |
SMP1_000064 | SMR000857194 | SPBio_002409 |
ST033520 | Sodium chenodeoxycholate | Spectrum5_002009 |
TR-017501 | Tox21_110412 | Tox21_200491 |
UNII-0GEI24LG0J | UNII-JIY1ILR284 component RUDATBOHQWOJDD-BSWAIDMHSA-N | W-5059 |
Xenbilox | Z1270387252 | ZINC3914808 |
bmse000908 | chenodeoxycholic acid |