Drug

D0497 | chenodeoxycholic acid

Molecular Formula C24H40O4
Molecular Weight 392.6
Structure
State solid
Route of elimination About 80% of its bacterial metabolite lithocholate is excreted in the feces.
Absorption Chenodiol is well absorbed from the small intestine.

A

A05AA01 Chenodeoxycholic acid


[A05AA] Bile acids and derivatives


[A05A] BILE THERAPY


[A05] BILE AND LIVER THERAPY


[A] Alimentary tract and metabolism


Toxicity Dose Time Species Model Method Action Positive criterion Reference
OPENING OF PERMEABILITY TRANSITION PORE (PTP) rat isolated liver mitochondria increase 55
UNCOUPLING rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay Negative 53
ELECTRON TRANSPORT CHAIN rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay Negative 53

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 10 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 1 of 10 companies. For more detailed information, please visit ECHA C&L website


Of the 5 notification(s) provided by 9 of 10 companies with hazard statement code(s):


H302 (22.22%): Harmful if swallowed [Warning Acute toxicity, oral]


H312 (22.22%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H315 (55.56%): Causes skin irritation [Warning Skin corrosion/irritation]


H317 (11.11%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H319 (55.56%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H332 (22.22%): Harmful if inhaled [Warning Acute toxicity, inhalation]


H334 (11.11%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]


H335 (22.22%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H361 (33.33%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P261, P264, P270, P271, P272, P280, P281, P285, P301+P312, P302+P352, P304+P312, P304+P340, P304+P341, P305+P351+P338, P308+P313, P312, P321, P322, P330, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (+)-chenodeoxycholate (+)-chenodeoxycholic acid (3a,5b,7a)-3,7-dihydroxy-cholan-24-oate
    (3a,5b,7a)-3,7-dihydroxy-cholan-24-oic acid (3alpha,5alpha,7beta,8alpha,17alpha)-3,7-dihydroxycholan-24-oic acid (3alpha,5beta,7alpha,8xi)-3,7-dihydroxycholan-24-oic acid
    (3beta,7beta,8xi,9xi,14xi,17alpha)-3,7-dihydroxycholan-24-oic acid (3|A,5|A,7|A)-3,7-Dihydroxycholan-24-oic Acid (4R)-4-((1S,2S,7S,11S,5R,9R,10R,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo [8.7.0.0<2,7>.0<11,15>]heptadec-14-yl)pentanoic acid
    (4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0(2),.0(1)(1),(1)]heptadecan-14-yl]pentanoic acid (4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0?,?.0??,??]heptadecan-14-yl]pentanoic acid; (4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
    (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid (S)-Chenodeoxycholic Acid
    0DBBBC66-0CFA-4DB9-97F4-5B1492756A02 0GEI24LG0J 25795-EP2289883A1
    25795-EP2295411A1 25795-EP2315303A1 3,7-Dihydroxycholan-24-oic acid, (3.alpha.,5.beta.,7.alpha.)- #
    3-alpha,7-alpha-Dihydroxy-5-beta-cholan-24-oic acid 3-alpha,7-alpha-Dihydroxycholanic acid 3-alpha,7-alpha-Dihydroxycholansaeure
    3-alpha,7-alpha-Dihydroxycholansaeure [German] 3.alpha.,7.alpha.-Dihydroxy-5.beta.-cholan-24-oic acid 3.alpha.,7.alpha.-Dihydroxy-5.beta.-cholanic acid
    3.alpha.,7.alpha.-Dihydroxy-5.beta.-cholanoic acid 3.alpha.,7.alpha.-Dihydroxycholanic acid 3.alpha.,7.alpha.-Dihydroxycholansaeure
    3a,7a-dihydroxy-5b,14a,17b-cholanate 3a,7a-dihydroxy-5b,14a,17b-cholanic acid 3a,7a-dihydroxy-5b-cholan-24-oate
    3a,7a-dihydroxy-5b-cholan-24-oic acid 3a,7a-dihydroxy-5b-cholanate 3a,7a-dihydroxy-5b-cholanic acid
    3alpha, 7alpha,-dihydroxy-5beta-cholanic acid 3alpha, 7alpha-dihydroxy-5beta-cholanoic acid 3alpha,7alpha-Dihydroxy-5beta-cholan-24-oic acid
    3alpha,7alpha-Dihydroxy-5beta-cholanic acid 474-25-9 5-beta-Cholan-24-oic acid, 3-alpha,7-alpha-dihydroxy-
    5.beta.-Cholan-24-oic acid, 3.alpha.,7.alpha.-dihydroxy- 5beta-Cholanic acid-3alpha,7alpha-diol 7-alpha-Hydroxylithocholic acid
    7.alpha.-Hydroxylithocholic acid 7a-Hydroxy-desoxycholsaeure 7alpha-hydroxylithocholic acid
    AB00513822 AB00513822-06 AB00513822_07
    AB2000327 AKOS024280614 AS-13636
    Acide chenodeoxycholique Acide chenodeoxycholique [INN-French] Acido chenodeoxicholico
    Acido chenodeoxicholico [INN-Spanish] Acidum chenodeoxycholicum Acidum chenodeoxycholicum [INN-Latin]
    Anthropodeoxycholic acid Anthropodesoxycholic acid Anthropododesoxycholic acid
    BDBM21674 BIDD:PXR0056 BPBio1_000210
    BRD-K18135438-001-16-7 BSPBio_000190 C-2900
    C02528 CAS-474-25-9 CCG-220285
    CCRIS 2195 CHEBI:16755 CHEMBL240597
    CHENIX (TN) CS-0834 Cdca
    Chendal Chendeoxycholic Acid Chendol
    Chenic acid Chenique Acid Chenix
    Chenocedon Chenocholic acid Chenocol
    Chenodeoxycholate Chenodeoxycholic acid (JP16/INN) Chenodeoxycholic acid (JP17/INN)
    Chenodeoxycholic acid [INN] Chenodeoxycholic acid, 500 mug/mL in methanol, certified reference material Chenodeoxycholic acid, >=97%
    Chenodeoxycholic acid, European Pharmacopoeia (EP) Reference Standard Chenodesoxycholic acid Chenodesoxycholsaeure
    Chenodesoxycholsaeure [German] Chenodex Chenodiol
    Chenodiol (USAN) Chenodiol [USAN] Chenodiol;Chenodesoxycholic acid;Chenocholic acid
    Chenofalk Chenorm Chenossil
    Cholan-24-oic acid, 3,7-dihydroxy-, (3-.alpha., 5-.beta., 7-.alpha.)- Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-alpha)- Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-alpha)- (9CI)
    Cholan-24-oic acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.alpha.)- Cholan-24-oic acid, 3,7-dihydroxy-, (3a,5b,7a)- Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7alpha)-
    Cholanorm D00163 DB06777
    DSSTox_CID_260 DSSTox_GSID_20260 DSSTox_RID_75469
    DTXSID2020260 Dihydroxy-3.alpha.,7.alpha.(5.beta.)Cholanic acid EC 207-481-8
    EINECS 207-481-8 Fluibil GTPL608
    Gallodesoxycholic acid HMS1568J12 HMS2095J12
    HMS2234I22 HMS3712J12 HSCI1_000210
    HY-76847 Hekbilin Henohol
    J10019 JN3 Kebilis
    LMST04010032 LS-7259 Leadiant (formerly Chenodeoxycholic acid sigma-tau)
    MCULE-3421183878 MLS002154253 NCGC00016387-02
    NCGC00142400-03 NCGC00142400-04 NCGC00258045-01
    NSC 657949 NSC-657949 NSC657949
    Prestwick0_000285 Prestwick1_000285 Prestwick2_000285
    Prestwick3_000285 Q419028 RUDATBOHQWOJDD-BSWAIDMHSA-N
    S1843 SBB002935 SCHEMBL25055
    SMP1_000064 SMR000857194 SPBio_002409
    ST033520 Sodium chenodeoxycholate Spectrum5_002009
    TR-017501 Tox21_110412 Tox21_200491
    UNII-0GEI24LG0J UNII-JIY1ILR284 component RUDATBOHQWOJDD-BSWAIDMHSA-N W-5059
    Xenbilox Z1270387252 ZINC3914808
    bmse000908 chenodeoxycholic acid

    DrugBank Name chenodeoxycholic acid
    DrugBank DB06777
    CAS Number 139953-73-4, 24404-86-2, 474-25-9
    PubChem Compound 10133
    KEGG Compound ID C02528
    KEGG Drug D00163
    ChEBI 16755