MITOTOX

Compound

D0521 | Diphenyleneiodonium chloride

Molecular Formula	C12H8ClI
Molecular Weight	314.55
Structure
Description	Flavin reagent; an inhibitor of NADPH oxidases (NOXes) and dual oxidases (DUOXes); potent and reversible inhibitor of nitric oxide synthetase; inhibits complex I

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ELECTRON TRANSPORT CHAIN						affect		69
ELECTRON TRANSPORT CHAIN	0.23 μM				NADH–Q-1c	decrease	IC50	128

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
NADH:ubiquinone reductase	0.23 μM				NADH–Q-1c	inhibitor	IC50	128
flavin mononucleotide						inhibitor		69

Pictogram	Signal	Statements	Precautionary Statement Codes
	Warning	The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]	P264, P280, P305+P351+P338, and P337+P313; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Warning

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264, P280, P305+P351+P338, and P337+P313; (The corresponding statement to each P-code can be found at the GHS Classification page.)

diphenyleneiodonium

CAS Number	10182-84-0, 244-54-2, 4673-26-1
PubChem Compound	2733504