MITOTOX

Compound

D0572 | (1,1,3,3-tetramethylbutyl)phenol

Properties

Molecular Formula	C14H22O
Molecular Weight	206.32
Structure

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	2.85±0.86	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	3.98	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	42.24±3.43	rat	hepatocytes	MMP assay	decrease	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 70 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 5 of 70 companies. For more detailed information, please visit ECHA C&L website Of the 1 notification(s) provided by 65 of 70 companies with hazard statement code(s): H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P264, P280, P302+P352, P305+P351+P338, P310, P312, P321, P322, P332+P313, P362, P363, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
	Danger	Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 1 of 2 companies. For more detailed information, please visit ECHA C&L website Of the 1 notification(s) provided by 1 of 2 companies with hazard statement code(s): H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 70 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 5 of 70 companies. For more detailed information, please visit ECHA C&L website

Of the 1 notification(s) provided by 65 of 70 companies with hazard statement code(s):

H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P264, P280, P302+P352, P305+P351+P338, P310, P312, P321, P322, P332+P313, P362, P363, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Danger

Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 1 of 2 companies. For more detailed information, please visit ECHA C&L website

Of the 1 notification(s) provided by 1 of 2 companies with hazard statement code(s):

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure

Respiratory tract irritation]

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

(1,1,3,3-TETRAMETHYLBUTYL)PHENOL	2-(1,1,3,3-Tetramethylbutyl)phenol	2-(2,4,4-trimethylpentan-2-yl)phenol
2-tert-octylphenol	3884-95-5	CAS-27193-28-8
CHEMBL3182290	CTK8I5446	Caswell No. 613D
DSSTox_CID_7925	DSSTox_GSID_27925	DSSTox_RID_78614
DTXSID7042271	EINECS 223-420-8	EINECS 248-310-7
EPA Pesticide Chemical Code 064118	LS-105013	NCGC00259873-01
Phenol, (1,1,3,3-tetramethylbutyl)-	Phenol, 2-(1,1,3,3-tetramethylbutyl)-	Q27288476;
S262P7049B	SCHEMBL324566	Tox21_202324
UNII-S262P7049B	USAF RH-6	XSXWOBXNYNULJG-UHFFFAOYSA-N
ZINC1849861	o-(1,1,3,3-Tetramethylbutyl)phenol	o-tert-Octylphenol
t-octylphenol	tert-Octylphenol

External IDs

CAS Number	27193-28-8, 3884-95-5
PubChem Compound	62530