D0587 | 1,2-benzisothiazolin-3-one
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 38.57±13.65 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 17.78 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
   |
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H315: Causes skin irritation [Warning Skin corrosion/irritation] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] |
P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 2915 companies from 33 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 1 of 2915 companies. For more detailed information, please visit ECHA C&L website Of the 32 notification(s) provided by 2914 of 2915 companies with hazard statement code(s): H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (99.93%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin] H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H400 (99.59%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H315: Causes skin irritation [Warning Skin corrosion/irritation] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] |
P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H315: Causes skin irritation [Warning Skin corrosion/irritation] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] |
P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H315: Causes skin irritation [Warning Skin corrosion/irritation] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P309+P311, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | oral | 1020mg/kg (1020mg/kg) | Pharmacological Research Communications. Vol. 3, Pg. 385, 1971. | |
| mouse | LD50 | oral | 1150mg/kg (1150mg/kg) | Pharmacological Research Communications. Vol. 3, Pg. 385, 1971. | |
| 1,2-BENZISOTHAZOL-3(2H)-ONE | 1,2-BENZISOTHIAZOL-3-ONE | 1,2-BIT |
| 1,2-Benzisothiazol-3(2H)-one | 1,2-Benzisothiazol-3(2H)-one, 97% | 1,2-Benzisothiazol-3(2H)-one, analytical standard |
| 1,2-Benzisothiazol-3-one (BIT) | 1,2-Benzisothiazolin-3-one | 1,2-Benzisothiazoline-3-one |
| 1,2-Benzisothiazolone | 1,2-Benzoisothiazol-3-one | 1,2-Benzoisothiazoline-3-one |
| 1,2-Benzothiazolinone | 1,2-benzisothiazole-3(2h)-one | 1,2-benzisothiazolinone |
| 1,2-benzoisothiazolin-3-one | 1,2-benzothiazol-3-one | 2,3-Dihydrobenzisothiazol-3-one |
| 2,3-dihydro-1,2-benzothiazol-3-one | 2,3-dihydro-3-oxo-1,2-benzisothiazole | 2-Thiobenzimide |
| 2634-33-5 | 3-Hydroxy-1,2-benzisothiazole | 34B335 |
| 40991-37-5 | 634B335 | A818398 |
| AB0008332 | AB1001358 | AC-2653 |
| ACMC-209u7v | AE-562/40151878 | AKOS001062434 |
| AKOS030227972 | AM20060449 | ANW-43433 |
| Acticide BIT | Acticide BW 20 | Apizas AP-DS |
| B2430 | BDBM46658 | BIT 10W |
| BIT 20 | BR-46705 | Benzisothiazol-3(2H)-one |
| Benzisothiazolin-3-one | Benzisothiazolone (BIT) | Benzo(d)isothiazol-3(2H)-one |
| Benzo[d]isothiazol-3(2H)-one | Benzo[d]isothiazol-3-ol | Benzo[d]isothiazol-3-one |
| Benzocil | Bestcide 200K | Bioban BIT 20DPG |
| C7H5NOS | CAS-2634-33-5 | CCRIS 6369 |
| CHEBI:167099 | CHEMBL297304 | CS-W018117 |
| CTK1A1874 | Canguard BIT | Canguard BIT 20DPG |
| Canguard Ultra BIT 20LE | Caswell No. 079A | Caswell No. 513A |
| DB-027306 | DMSMPAJRVJJAGA-UHFFFAOYSA-N | DSSTox_CID_12523 |
| DSSTox_GSID_32523 | DSSTox_RID_78967 | DTXSID5032523 |
| Denicide BIT | Denicide BIT 20N | EINECS 220-120-9 |
| EN300-17679 | EPA Pesticide Chemical Code 098901 | Epitope ID:115004 |
| F0288-0100 | FS-3163 | FT-0606282 |
| HMS1755P21 | HMS2706H20 | HRA0F1A4R3 |
| HSDB 8271 | IPX | InChI=1/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9; |
| KS-00000E5U | KSC201Q7J | Koralone B 119 |
| LS-33607 | M-4954 | MCULE-3257757873 |
| MFCD00127753 | MLS-0254244.0001 | MLS000771034 |
| NCGC00164206-01 | NCGC00248077-01 | NCGC00254467-01 |
| NE11261 | Nipacide BIT | Nipacide BIT 10W |
| Nipacide BIT 20 | Nuosept 485 | Nuosept 491 |
| Nuosept 495 | Parmetol B 70 | Parmetol D 11 |
| Preventol BIT 20D | Proxel | Proxel AB |
| Proxel BD | Proxel BD 20 | Proxel BDN |
| Proxel CF | Proxel GXL | Proxel GXL(S) |
| Proxel HL 2 | Proxel LV-S | Proxel PL |
| Proxel Press Paste | Proxel Press Paste D | Proxel TN |
| Proxel Ultra 5 | Proxel XL | Proxel XL 2 |
| PubChem15685 | Q411746 | REGID_for_CID_17520 |
| SC-15324 | SCHEMBL26078 | SCHEMBL5586024 |
| SD 202 | SD 202 (bactericide) | SMR000344133 |
| San-aibac AP | Topcide 600 | Tox21_300489 |
| Troysan 1050 | UNII-HRA0F1A4R3 | US9011882, Table 1, Compound 20 |
| W-107178 | XBINX | Z56983154 |
| ZINC2581983 | benzisothiazoline-3-one | benzisothiazolone |
| benzoisothiazol-3-one | cid_17520 |