Compound

D0587 | 1,2-benzisothiazolin-3-one

Molecular Formula C7H5NOS
Molecular Weight 151.19
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 38.57±13.65 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 17.78 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 2915 companies from 33 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 1 of 2915 companies. For more detailed information, please visit ECHA C&L website


Of the 32 notification(s) provided by 2914 of 2915 companies with hazard statement code(s):


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (99.93%): Causes skin irritation [Warning Skin corrosion/irritation]


H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]


H400 (99.59%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P260, P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P309+P311, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 oral 1020mg/kg (1020mg/kg) Pharmacological Research Communications. Vol. 3, Pg. 385, 1971.
mouse LD50 oral 1150mg/kg (1150mg/kg) Pharmacological Research Communications. Vol. 3, Pg. 385, 1971.


  • 1,2-BENZISOTHAZOL-3(2H)-ONE 1,2-BENZISOTHIAZOL-3-ONE 1,2-BIT
    1,2-Benzisothiazol-3(2H)-one 1,2-Benzisothiazol-3(2H)-one, 97% 1,2-Benzisothiazol-3(2H)-one, analytical standard
    1,2-Benzisothiazol-3-one (BIT) 1,2-Benzisothiazolin-3-one 1,2-Benzisothiazoline-3-one
    1,2-Benzisothiazolone 1,2-Benzoisothiazol-3-one 1,2-Benzoisothiazoline-3-one
    1,2-Benzothiazolinone 1,2-benzisothiazole-3(2h)-one 1,2-benzisothiazolinone
    1,2-benzoisothiazolin-3-one 1,2-benzothiazol-3-one 2,3-Dihydrobenzisothiazol-3-one
    2,3-dihydro-1,2-benzothiazol-3-one 2,3-dihydro-3-oxo-1,2-benzisothiazole 2-Thiobenzimide
    2634-33-5 3-Hydroxy-1,2-benzisothiazole 34B335
    40991-37-5 634B335 A818398
    AB0008332 AB1001358 AC-2653
    ACMC-209u7v AE-562/40151878 AKOS001062434
    AKOS030227972 AM20060449 ANW-43433
    Acticide BIT Acticide BW 20 Apizas AP-DS
    B2430 BDBM46658 BIT 10W
    BIT 20 BR-46705 Benzisothiazol-3(2H)-one
    Benzisothiazolin-3-one Benzisothiazolone (BIT) Benzo(d)isothiazol-3(2H)-one
    Benzo[d]isothiazol-3(2H)-one Benzo[d]isothiazol-3-ol Benzo[d]isothiazol-3-one
    Benzocil Bestcide 200K Bioban BIT 20DPG
    C7H5NOS CAS-2634-33-5 CCRIS 6369
    CHEBI:167099 CHEMBL297304 CS-W018117
    CTK1A1874 Canguard BIT Canguard BIT 20DPG
    Canguard Ultra BIT 20LE Caswell No. 079A Caswell No. 513A
    DB-027306 DMSMPAJRVJJAGA-UHFFFAOYSA-N DSSTox_CID_12523
    DSSTox_GSID_32523 DSSTox_RID_78967 DTXSID5032523
    Denicide BIT Denicide BIT 20N EINECS 220-120-9
    EN300-17679 EPA Pesticide Chemical Code 098901 Epitope ID:115004
    F0288-0100 FS-3163 FT-0606282
    HMS1755P21 HMS2706H20 HRA0F1A4R3
    HSDB 8271 IPX InChI=1/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9;
    KS-00000E5U KSC201Q7J Koralone B 119
    LS-33607 M-4954 MCULE-3257757873
    MFCD00127753 MLS-0254244.0001 MLS000771034
    NCGC00164206-01 NCGC00248077-01 NCGC00254467-01
    NE11261 Nipacide BIT Nipacide BIT 10W
    Nipacide BIT 20 Nuosept 485 Nuosept 491
    Nuosept 495 Parmetol B 70 Parmetol D 11
    Preventol BIT 20D Proxel Proxel AB
    Proxel BD Proxel BD 20 Proxel BDN
    Proxel CF Proxel GXL Proxel GXL(S)
    Proxel HL 2 Proxel LV-S Proxel PL
    Proxel Press Paste Proxel Press Paste D Proxel TN
    Proxel Ultra 5 Proxel XL Proxel XL 2
    PubChem15685 Q411746 REGID_for_CID_17520
    SC-15324 SCHEMBL26078 SCHEMBL5586024
    SD 202 SD 202 (bactericide) SMR000344133
    San-aibac AP Topcide 600 Tox21_300489
    Troysan 1050 UNII-HRA0F1A4R3 US9011882, Table 1, Compound 20
    W-107178 XBINX Z56983154
    ZINC2581983 benzisothiazoline-3-one benzisothiazolone
    benzoisothiazol-3-one cid_17520

    CAS Number 2634-33-5, 40991-37-5
    PubChem Compound 17520
    ChEBI 167099