D0588 | 1,2-phenylenediamine
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 3.90±3.61 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 2.51 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 17.85±6.50 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
    |
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332: Harmful if inhaled [Warning Acute toxicity, inhalation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P261, P264, P270, P271, P272, P273, P280, P281, P301+P310, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P333+P313, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Danger |
Aggregated GHS information provided by 423 companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H312+H332 (19.39%): Harmful in contact with skin or if inhaled [Warning Acute toxicity, dermal acute toxicity, inhalation] H312 (99.76%): Harmful in contact with skin [Warning Acute toxicity, dermal] H317 (99.76%): May cause an allergic skin reaction [Warning Sensitization, Skin] H319 (99.76%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (99.76%): Harmful if inhaled [Warning Acute toxicity, inhalation] H341 (99.53%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351 (98.82%): Suspected of causing cancer [Warning Carcinogenicity] H400 (98.82%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (99.76%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P261, P264, P270, P271, P272, P273, P280, P281, P301+P310, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P333+P313, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332: Harmful if inhaled [Warning Acute toxicity, inhalation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P261, P264, P270, P271, P272, P273, P280, P281, P301+P310, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P333+P313, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] |
P201, P202, P260, P261, P264, P270, P272, P280, P281, P301+P312, P302+P352, P305+P351+P338, P307+P311, P308+P313, P309+P311, P314, P321, P330, P333+P313, P337+P313, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H316: Causes mild skin irritation [Warning Skin corrosion/irritation] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] |
P201, P202, P260, P261, P264, P270, P271, P272, P280, P281, P284, P301+P312, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P309+P311, P310, P314, P320, P321, P330, P332+P313, P333+P313, P337+P313, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P261, P264, P270, P271, P272, P273, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P309+P311, P312, P314, P321, P330, P333+P313, P337+P313, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | subcutaneous | 250mg/kg (250mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 140, 1930. | |
| frog | LDLo | subcutaneous | 4gm/kg (4000mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 140, 1930. | |
| mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | National Technical Information Service. Vol. AD414-344, | |
| rabbit | LD | subcutaneous | > 500mg/kg (500mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 140, 1930. | |
| rat | LDLo | subcutaneous | 600mg/kg (600mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 140, 1930. | |
| rat | LD50 | intraperitoneal | 290mg/kg (290mg/kg) | Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973, | |
| (2-aminophenyl)-amine | 0-phenylendiamine | 0-phenylenediamine |
| 1,2 phenylene diamine | 1,2 phenylenediamine | 1,2-Benzenediamine |
| 1,2-Benzenediamine, hydrochloride (1:2) | 1,2-DIAMINO-BENZENE | 1,2-Diaminobenzene |
| 1,2-Diaminobenzene | 1,2-Fenylendiamin | 1,2-Fenylendiamin [Czech] |
| 1,2-Phenylenediamine | 1,2-Phenylenediamine | 1,2-Phenylenediamine 1000 microg/mL in Acetonitrile |
| 1,2-benzenedi-amine | 1,2-phenylendiamine | 1,2-phenylene diamine |
| 1,2-phenylene-diamine | 1.2-diaminobenzene | 1.2-phenylenediamine |
| 177737-EP2277862A2 | 177737-EP2280282A1 | 2-Amino-aniline |
| 2-Aminoaniline | 2-Phenylene diamine | 2-Phenylene diamine (1,2Phenylenediamine) |
| 2-aminophenylamine | 33225-EP2276085A1 | 33225-EP2284920A1 |
| 33225-EP2292586A2 | 33225-EP2295421A1 | 33225-EP2298828A1 |
| 33225-EP2299509A1 | 33225-EP2301983A1 | 33225-EP2305643A1 |
| 33225-EP2311815A1 | 33225-EP2371810A1 | 33225-EP2371812A1 |
| 33225-EP2372804A1 | 33225-EP2378585A1 | 4-13-00-00038 (Beilstein Handbook Reference) |
| 80449-EP2280008A2 | 80449-EP2292597A1 | 80449-EP2298770A1 |
| 80449-EP2305250A1 | 8B713N8Q0F | 95-54-5 |
| AB1003779 | AC-907/25014349 | ACMC-209rzd |
| AI3-24343 | AKOS000119133 | ANW-40535 |
| BCP25295 | BIDD:ER0680 | BP-11855 |
| BRN 0606074 | C.I. 76010 | C.I. Oxidation Base 16 |
| C14402 | CAS-95-54-5 | CCG-35856 |
| CCRIS 508 | CHEBI:34043 | CHEMBL70582 |
| CI 76010 | CI Oxidation Base 16 | CTK1A4112 |
| DSSTox_CID_5881 | DSSTox_GSID_25881 | DSSTox_RID_77958 |
| DTXSID3025881 | EC 202-430-6 | EINECS 202-430-6 |
| EK 1700 | F1908-0114 | FT-0662537 |
| GEYOCULIXLDCMW-UHFFFAOYSA-N | H444 | HSDB 2893 |
| IK 3 | InChI=1/C6H8N2/c7-5-3-1-2-4-6(5)8/h1-4H,7-8H; | KS-00000YB2 |
| LS-1980 | MCULE-9134155552 | MFCD00007721 |
| NCGC00090885-01 | NCGC00090885-02 | NCGC00090885-03 |
| NCGC00090885-04 | NCGC00090885-05 | NCGC00090885-06 |
| NCI60_004318 | NCIMech_000739 | NE10509 |
| NSC 5354 | NSC-5354 | NSC5354 |
| O-PHENYLENEDIAMINE | OPD | OPDA |
| Orthamine | P0168 | P0968 |
| P1805 | PHENYLENDIAMINE | PODA |
| Phenylene diamine | Phenylenediamine, o-, and its salt | Phenylenediamine, ortho- |
| Q3596763 | RTR-038559 | SBB040801 |
| SC-26371 | SCHEMBL11062175 | SCHEMBL6187 |
| SQ 15500 | ST24030101 | ST45061692 |
| STK301816 | STR03001 | TR-038559 |
| Tox21_400014 | UNII-8B713N8Q0F | UNII-TJX894Z2PK component GEYOCULIXLDCMW-UHFFFAOYSA-N |
| W-100163 | WLN: ZR BZ | Z1245635791 |
| ZINC4316 | benzene-1,2-diamine | o-Aminoaniline |
| o-Benzenediamine | o-Diaminobenzene | o-Fenylendiamin |
| o-Fenylendiamin [Czech] | o-Phenylene diamine | o-Phenylenediamine |
| o-Phenylenediamine [UN1673] [Keep away from food] | o-Phenylenediamine [UN1673] [Keep away from food] | o-Phenylenediamine, 98% |
| o-Phenylenediamine, Peroxidase substrate, >=98.0%, powder | o-Phenylenediamine, flaked, 99.5% | o-Phenylenediamine, for fluorescence, free base |
| o-Phenylenediamine, sublimed, >=99% | o-Phenylenediamine, suitable for fluorescence, >=99.0% (NT) | o-Phenylenediamine, tablet, 20 mg substrate per tablet |
| o-phenyl-enediamine | o-phenyle-nediamine | o-phenylendiamin |
| o-phenylendiamine | o-phenylene-diamine | ortho phenylene diamine |
| ortho-Phenylenediamine | ortho-aminoaniline | ortho-diaminobenzene |
| orthophenylenediamine | phenylene-1,2-dimaine |