D0589 | 1,2-phenylenediamine dihydrochloride
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 0.44±0.20 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 1.78 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 14.22±2.30 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
    |
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332: Harmful if inhaled [Warning Acute toxicity, inhalation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P261, P264, P270, P271, P272, P273, P280, P281, P301+P310, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P333+P313, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Danger |
Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal] H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation] H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351 (100%): Suspected of causing cancer [Warning Carcinogenicity] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P261, P264, P270, P271, P272, P273, P280, P281, P301+P310, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P333+P313, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332: Harmful if inhaled [Warning Acute toxicity, inhalation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P261, P264, P270, P271, P272, P273, P280, P281, P301+P310, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P333+P313, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] |
P201, P202, P260, P261, P264, P270, P271, P272, P280, P281, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P309+P311, P312, P314, P321, P333+P313, P337+P313, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | subcutaneous | 250mg/kg (250mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 140, 1930. | |
| frog | LDLo | subcutaneous | 4gm/kg (4000mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 140, 1930. | |
| mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | National Technical Information Service. Vol. AD414-344, | |
| rabbit | LD | subcutaneous | > 500mg/kg (500mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 140, 1930. | |
| rat | LDLo | subcutaneous | 600mg/kg (600mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 140, 1930. | |
| rat | LD50 | intraperitoneal | 290mg/kg (290mg/kg) | Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973, | |
| 1,2-BENZENEDIAMINE DIHYDROCHLORIDE | 1,2-Benzenediamine, dihydrochloride | 1,2-Benzenediamine, hydrochloride (1:2) |
| 1,2-Diaminobenzene Dihydrochloride | 1,2-Phenylenediamine dihydrochloride | 1,2-phenylenediamine bishydrochloride |
| 615-28-1 | 7682AF | ACMC-209mtk |
| AI3-50519 | AKOS016353189 | ANW-33846 |
| AS-40012 | CAS-615-28-1 | CHEMBL3183208 |
| CTK3J1878 | DB-053918 | DSSTox_CID_1140 |
| DSSTox_GSID_21140 | DSSTox_RID_75971 | DTXSID3021140 |
| EINECS 210-418-7 | F1905-7101 | HSDB 6232 |
| KS-000010WH | KSC491Q7R | LS-7652 |
| MCULE-6086072969 | MFCD00012966 | NCGC00258533-01 |
| O-PHENYLENEDIAMINE 2HCL | OPD.2HCl | Opd Easy-Tablets |
| P0171 | P1144 | PubChem23346 |
| Q26841263 | RIIWUGSYXOBDMC-UHFFFAOYSA-N | RTR-021191 |
| SC-47879 | SCHEMBL39679 | TR-021191 |
| TRA0036714 | Tox21_200980 | UNII-Z16252Z50J |
| USAF EK-678 | Z16252Z50J | benzene-1,2-diamine dihydrochloride |
| o-Phenylenediamine dihydrochloride | o-Phenylenediamine dihydrochloride, 99+% | o-Phenylenediamine dihydrochloride, >=99.0% (AT) |
| o-Phenylenediamine dihydrochloride, peroxidase substrate | o-Phenylenediamine dihydrochloride, tablet, 1 mg substrate per tablet | o-Phenylenediamine dihydrochloride, tablet, 10 mg substrate per tablet |
| o-Phenylenediamine dihydrochloride, tablet, 15 mg substrate per tablet | o-Phenylenediamine dihydrochloride, tablet, 2 mg substrate per tablet | o-Phenylenediamine dihydrochloride, tablet, 20 mg substrate per tablet |
| o-Phenylenediamine dihydrochloride, tablet, 3 mg substrate per tablet | o-Phenylenediamine dihydrochloride, tablet, 30 mg substrate per tablet | o-Phenylenediamine dihydrochloride, tablet, 4 mg substrate per tablet |
| o-Phenylenediamine dihydrochloride, tablet, 5 mg substrate per tablet | o-Phenylenediamine dihydrochloride, tablet, 60 mg substrate per tablet; | o-Phenylenediamine.2HCl |
| o-phenylenediamine dihcl | o-phenylenediaminedihydrochloride | phenylenediamine bis-hydrochloride |
| CAS Number | 615-28-1, 95-54-5 |
| PubChem Compound | 11990 |