MITOTOX

Compound

D0597 | 1,4-naphthalenediamine

Properties

Molecular Formula	C10H10N2
Molecular Weight	158.2
Structure

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	0.20±0.08	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	2	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	22.71±8.75	rat	hepatocytes	MMP assay	decrease	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Warning	Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Warning

Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

(4-amino-1-naphthyl)amine	1,4-Diaminonaphthalene	1,4-Diaminonaphthalene, 97%
1,4-Naphthalene diamine	1,4-Naphthalenediamine	1,4-Naphthylendiamin
1,4-Naphthylenediamine	2243-61-0	4-13-00-00338 (Beilstein Handbook Reference)
A816205	ACM2243610	ACMC-20ap2m
AKOS022185645	AS-57773	BRN 2803026
CAS-2243-61-0	CCRIS 6072	CHEMBL3183071
CTK1A2297	DSSTox_CID_5696	DSSTox_GSID_25696
DSSTox_RID_77885	DTXSID6025696	EINECS 218-816-2
FCH1122452	FT-0737124	J-014716;
LS-1022	MCULE-6550730089	NCGC00260446-01
Naphthalene-1,4-diamine	OKBVMLGZPNDWJK-UHFFFAOYSA-N	SCHEMBL201893
TC-172165	Tox21_202900	W-8577
ZINC26481333	ZX-CM011436

External IDs

CAS Number	2243-61-0
PubChem Compound	16719