D0618 | 1-naphthol
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 31.04±5.96 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 31.62 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H315: Causes skin irritation [Warning Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] |
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
  |
Danger |
Aggregated GHS information provided by 620 companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H311 (26.61%): Toxic in contact with skin [Danger Acute toxicity, dermal] H312 (73.23%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (99.84%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (20%): May cause an allergic skin reaction [Warning Sensitization, Skin] H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H335 (99.84%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H400 (20%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (13.39%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] H412 (19.03%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P333+P313, P361, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H315: Causes skin irritation [Warning Skin corrosion/irritation] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] |
P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P333+P313, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] |
P260, P264, P270, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P310, P312, P321, P322, P361, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 275mg/kg (275mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965. | |
| rabbit | LD50 | skin | 880mg/kg (880mg/kg) | American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962. | |
| guinea pig | LD50 | oral | 2gm/kg (2000mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965. | |
| rabbit | LD50 | oral | 9gm/kg (9000mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965. | |
| cat | LD50 | oral | 134mg/kg (134mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965. | |
| rat | LC50 | inhalation | > 420mg/m3/1H (420mg/m3) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 25-4/1973, | |
| rabbit | LDLo | unreported | 9100mg/kg (9100mg/kg) | Yakkyoku. Pharmacy. Vol. 32, Pg. 605, 1981. | |
| rat | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | Office of Toxic Substances Report. Vol. FYI-OTS-0885-0443, | |
| rat | LD50 | oral | 1870mg/kg (1870mg/kg) | Office of Toxic Substances Report. Vol. FYI-OTS-0885-0443, | |
| (+)-naphthol | .alpha.-Hydroxynaphthalene | .alpha.-Naphthol |
| 1-Hydroxynaphthalene | 1-Hydroxynaphthalene | 1-NAPHTHOL |
| 1-Naphthalenol | 1-Naphthalenol | 1-Naphthol |
| 1-Naphthol 100 microg/mL in Methanol | 1-Naphthol, 99+% | 1-Naphthol, >=98.0% (GC) |
| 1-Naphthol, BioXtra, >=99% | 1-Naphthol, LR, >=99% | 1-Naphthol, PESTANAL(R), analytical standard |
| 1-Naphthol, Pure PA, 99% | 1-Naphthol, ReagentPlus(R), >=99% | 1-Naphthol, SAJ special grade, >=99.0% |
| 1-Naphthol, Vetec(TM) reagent grade, 98% | 1-Naphthol, certified reference material, TraceCERT(R) | 1-Naphthol, p.a., 99.0% |
| 1-Naphthol, puriss. p.a., Reag. Ph. Eur., >=99% (GC) | 1-Naphthol, puriss., for fluorescence, >=99.0% (GC) | 1-Naphthyl Alcohol |
| 1-Naphthyl alcohol | 1-Naphtol | 1-napthol |
| 1321-67-1 | 1NP | 2A71EAQ389 |
| 33420_RIEDEL | 35825_RIEDEL | 4b33 |
| 50356-21-3; | 70438_FLUKA | 70442_FLUKA |
| 8 -naphthol | 90-15-3 | A843458 |
| AB-131/40232333 | ACMC-20ait6 | ACT07473 |
| AI3-00106 | AK-44442 | AKOS000118822 |
| ANW-75304 | BBL011611 | BDBM23450 |
| Basf Ursol ERN | C.I. 76605 | C.I. Oxidation Base 33 |
| C11714 | CAS-90-15-3 | CCRIS 1172 |
| CHEBI:10319 | CHEMBL122617 | CI 76605 |
| CI Oxidation Base 33 | CS-W020125 | CTK0H9561 |
| DSSTox_CID_1793 | DSSTox_GSID_21793 | DSSTox_RID_76330 |
| DTXSID6021793 | Duloxetine EP Impurity D (1-Naphthol) | Durafur developer D |
| EBD2205191 | EINECS 201-969-4 | F1908-0108 |
| FT-0608111 | Fouramine ERN | Fourrine 99 |
| Fourrine ERN | Furro ER | GS-6917 |
| HSDB 2650 | HY-Y1309 | Hydroxynaphthalene |
| InChI=1/C10H8O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-7,11 | J-610055 | KJCVRFUGPWSIIH-UHFFFAOYSA-N |
| KSC179K6D | LS-95401 | M-5886 |
| MCULE-2825050946 | MFCD00003930 | N0026 |
| N0864 | N1000_SIAL | N2780_SIAL |
| NAPHTHOL | NCGC00249169-01 | NCGC00256563-01 |
| NCGC00259669-01 | NSC 9586 | NSC-9586 |
| NSC9586 | Nako TRB | Naphth-1-ol, 9 |
| Naphthalenol | Naphthol 1 | Naphthol-1 |
| Naphthyl-1-ol | PubChem16938 | Q408876 |
| QC-1267 | RTR-028364 | SBB040845 |
| SCHEMBL3416 | SGCUT00118 | ST2413618 |
| ST50214429 | ST5214429 | STL163337 |
| TR-028364 | Tertral ERN | Tox21_202120 |
| Tox21_302768 | UNII-2A71EAQ389 | Ursol ERN |
| WLN: L66J BQ | Z1262254359 | ZINC00967929 |
| ZINC4292977 | Zoba ERN | alpha naphthol |
| alpha-Hydroxynaphthalene | alpha-Naphthol, 1-Naphthol | alpha-Naphthyl alcohol |
| alpha-naphthol | alpha-napthol | hydroxy naphthalene |
| hydroxynaphthalene | naphthalen-1-ol | naphthalene-1-ol |
| napthalenol | napthyl alcohol | nchembio791-comp4 |
| to_000072 |