Compound
D0633 | 2,2'-methylenebis(4-methyl-6-tert-butylphenol)
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 1.35±0.26 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 2 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 3.71±0.47 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 792 companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 156 of 792 companies. For more detailed information, please visit ECHA C&L website Of the 26 notification(s) provided by 636 of 792 companies with hazard statement code(s): H361 (79.72%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H413 (73.74%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P273, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H360F: May damage fertility [Danger Reproductive toxicity] |
P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 11gm/kg (11000mg/kg) | Journal of Toxicological Sciences. Vol. 19, Pg. 77, 1994. | |
| rat | LDLo | oral | 10gm/kg (10000mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(8), Pg. 28, 1973. | |
| 119-47-1 | 2,1-dimethylethyl)-p-cresol] | 2,2'- methylene bis(4-methyl-6-tert. butylphenol) |
| 2,2'-Bis(4-methyl-6-tert-butylphenol)methane | 2,2'-Bis-6-terc.butyl-p-kresylmethan | 2,2'-Bis-6-terc.butyl-p-kresylmethan [Czech] |
| 2,2'-Methylene-bis(6-tert-butyl)-para-cresol | 2,2'-Methylene-bis(6-tert-butyl-4-methylphenol) | 2,2'-Methylene-bis-(4-methyl-6-t-butylphenol) |
| 2,2'-Methylenebis 6-(1,1-dimethylethyl)-4-methyl-phenol | 2,2'-Methylenebis(4-methyl-6-t-butylphenol) | 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) |
| 2,2'-Methylenebis(6-(1,1-dimethylethyl)-p-cresol) | 2,2'-Methylenebis(6-t-butyl-4-methylphenol) | 2,2'-Methylenebis(6-tert-butyl-4-methyl-phenol) |
| 2,2'-Methylenebis(6-tert-butyl-4-methylphenol) | 2,2'-Methylenebis(6-tert-butyl-p-cresol) | 2,2'-Methylenebis[4-Methyl-6-tert-butylphenol] |
| 2,2'-Methylenebis[6-tert-butyl-p-cresol] | 2,2'-methanediylbis(6-tert-butyl-4-methylphenol) | 2,2'-methanediylbis[6-(1,1-dimethylethyl)-4-methylphenol] |
| 2,2'-methyl enebis(4-methyl-6-t-butylphenol) | 2,2'-methylene-bis(4-methyl-6-t-butylphenol) | 2,2'-methylene-bis(4-methyl-6-tert-butylphenol) |
| 2,2'-methylene-bis(4-methyl-6-tert.butylphenol) | 2,2'-methylene-bis(4-methyl-6-tertiarybutylphenol) | 2,2'-methylene-bis-(4-methyl-6-tert-butylphenol) |
| 2,2'-methylene-bis-(4-methyl-6-tert.butylphenol) | 2,2'-methylene-bis-(6-tert-butyl-4-methylphenol) | 2,2'-methylenebis (6-tert-butyl-4-methylphenol) |
| 2,2'-methylenebis(6-t-butyl-p-cresol) | 2,2'-methylenebis(6-tert-butyl-4-cresol) | 2,2'Methylenebis(6-tert-4-methylphenol) |
| 2,2-Methylene-Bis(4-Methyl-6-Tertiarybutylphenol) | 2,2-Methylenebis(4-methyl-6-t-butylphenol) | 2,2-methylenebis(6-tert-butyl-4-methylphenol) |
| 2,2-methylenebis(6-tert-butyl-p-cresol) | 2,2;-Methylenebis(4-methyl-6-tert | 2-(tert-butyl)-6-{[3-(tert-butyl)-2-hydroxy-5-methylphenyl]methyl}-4-methylphe nol; |
| 2-tert-Butyl-6-(2-hydroxy-3-tert-butyl-5-methyl-benzyl)-4-methyl-phenol | 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol | 3,3'-Di-tert-butyl-2,2'-dihydroxy-5,5'-dimethyldiphenylmethane |
| 4-06-00-06801 (Beilstein Handbook Reference) | 6,6'-Di-tert-butyl-2,2'-methylenedi-p-cresol | 6,6'-Methylenebis(2-(tert-butyl)-4-methylphenol) |
| 6,6'-methylenebis(2-tert-butyl-4-methylphenol) | A 22-46 | A-22-46 |
| ACMC-1BUVJ | AI3-18027 | AK-28736 |
| AKOS000447157 | ANW-17334 | AO 1 |
| AO 1 (Antioxidant) | AO 1 (VAN) | AO 2246 |
| AO1 | AS-13205 | AX8017725 |
| Advastab 405 | Agidol 2 | Alterungsschutzmittel BKF |
| Antage W 400 | Anti Ox | Antioxidant 1 |
| Antioxidant 2246 | Antioxidant BKF | Antioxidant NG-2246 |
| Antioxidant OMB | BBL025607 | BIDD:ER0324 |
| BIS(2-HYDROXY-3-TERT-BUTYL-5-METHYLPHENYL)METHANE | BKF | BRN 2062676 |
| Bis(3-tert-butyl-2-hydroxy-5-methylphenyl)methane | Bis(6-hydroxy-3-methyl-5-tert-butylphenyl)methane | Bisaklofen BP |
| Bisalkofen BP | CAO 14 | CAO 5 |
| CAO-14 | CAO-5 | CAS-119-47-1 |
| CCG-207916 | CCG-208597 | CCRIS 4919 |
| CHEMBL460648 | CTK8A9397 | Calco 2246 |
| Catolin 14 | Chemanox 21 | Cyanox 2246 |
| DSSTox_CID_870 | DSSTox_GSID_20870 | DSSTox_RID_75838 |
| DTXSID4020870 | Di(2-hydroxy-5-methyl-3-tert-butylphenyl)methane | EC 204-327-1 |
| EINECS 204-327-1 | FR-0126 | FT-0609309 |
| GERI-BP002-A | H598 | HSDB 5585 |
| Ionol 46 | J-004134 | KGRVJHAUYBGFFP-UHFFFAOYSA-N |
| KS-00000W13 | KVM0X4X57B | LS-7516 |
| Lederle 2246 | Lowinox 22M46 | M0217 |
| MBMBP | MCULE-8897993815 | MLS-0146298.0001 |
| Methane, 2,2'-bis(6-t-butyl-p-cresyl)- | Methane, 2,2'-bis(6-tert-butyl-p-cresyl)- | Methane,2'-bis(6-tert-butyl-p-cresyl)- |
| Methylene bis methyl butyl phenol | NCGC00164172-01 | NCGC00164172-02 |
| NCGC00256347-01 | NCGC00259079-01 | NG 2246 |
| NSC 7781 | NSC-7781 | NSC7781 |
| Nocrac NS 6 | Nocrack NS 6 | OXY CHEK 114 |
| Oprea1_122036 | Phenol, 2,2'-methylenebis(6-(1,1-dimethylethyl)-4-methyl- | Phenol, 2,2'-methylenebis*6-(1,1-dimethylethyl)-4-methyl- |
| Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl- | Phenol,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl- | Plastanox 2246 |
| Plastanox 2246 Antioxidant | Q16830225 | RTR-003271 |
| Ralox 46 | Rubber Antioxidant 2246 | SBB007695 |
| SC-79689 | SCHEMBL34162 | ST24029563 |
| STL377901 | Sumilizer MDP | Synox 5lt |
| TR-003271 | Tox21_201529 | Tox21_302923 |
| UNII-KVM0X4X57B | Vulkanox bkf | WLN: 1X1 & 1 & R BQ C3R BQ CX1 & 1 & 1 |
| ZINC1543799 | bis(2-hydroxy-5-methyl-3-tert-butylphenyl)methane | methylene di-t-butylcresol |
| p-Cresol, 2,2'-methylenebis(6-tert- butyl- | p-Cresol, 2,2'-methylenebis(6-tert-butyl- | p-Cresol, 2,2'-methylenebis(6-tert-butyl- (8CI) |
| p-Cresol, 2,2'-methylenebis*6-tert-butyl- | p-Cresol, 2,2'-methylenebis[6-tert-butyl- | p-Cresol,2'-methylenebis[6-tert-butyl- |
| CAS Number | 119-47-1 |
| PubChem Compound | 8398 |