D0708 | 4-(1,1,3,3-tetramethylbutyl)phenol
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 4.25±0.92 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 4.89 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
H315: Causes skin irritation [Warning Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P264, P273, P280, P302+P352, P305+P351+P338, P310, P321, P332+P313, P362, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
Aggregated GHS information provided by 1825 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 3 of 1825 companies. For more detailed information, please visit ECHA C&L website Of the 14 notification(s) provided by 1822 of 1825 companies with hazard statement code(s): H312 (45.94%): Harmful in contact with skin [Warning Acute toxicity, dermal] H314 (21.73%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H315 (78.27%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (78.27%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H400 (99.95%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P264, P273, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P332+P313, P362, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
H315: Causes skin irritation [Warning Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P264, P273, P280, P302+P352, P305+P351+P338, P310, P321, P332+P313, P362, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
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Danger |
H315: Causes skin irritation [Warning Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P264, P273, P280, P302+P352, P305+P351+P338, P310, P321, P332+P313, P362, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Warning |
H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P264, P273, P280, P281, P302+P352, P305+P351+P338, P308+P313, P312, P314, P322, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Warning |
H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure Narcotic effects] H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] |
P201, P202, P260, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P314, P322, P337+P313, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 25mg/kg (25mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| 140-66-9 | 2025AB | 27L |
| 4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL | 4-(1,1,3,3-TetraMethyl-Butyl)Phenol | 4-(1,1,3,3-Tetramethylbutyl)phenol (ACD/Name 4.0) |
| 4-(1,1,3,3-tetramethyl-butyl)-phenol | 4-(1,1,3,3-tetramethylbutyl)-phenol | 4-(1,3,3-Tetramethylbutyl)phenol |
| 4-(2,4,4-trimethylpentan-2-yl)phenol | 4-(TERT-OCTYL)PHENOL | 4-06-00-03484 (Beilstein Handbook Reference) |
| 4-t-Octylphenol | 4-tert-Octylphenol | 4-tert-Octylphenol solution, 1 mug/mL in acetone, analytical standard |
| 4-tert-Octylphenol solution, 10 mug/mL in acetone, analytical standard | 4-tert-Octylphenol solution, 1000 mug/mL in acetone, analytical standard | 4-tert-Octylphenol, 97% |
| 4-tert-Octylphenol, analytical standard | 4-tert-Octylphenol, certified reference material, TraceCERT(R) | 4-tert-octyl-phenol |
| 4-tert.-octylphenol | 4mga | ACMC-1C0TS |
| AI3-10011 | AKOS005516422 | ANW-20579 |
| BBL027379 | BDBM50423506 | BIDD:ER0044 |
| BRD-K64273664-001-01-6 | BRN 0513992 | C14205 |
| CAS-140-66-9 | CCRIS 8947 | CHEBI:34445 |
| CHEMBL259327 | CTK3J1965 | DB-063344 |
| DSSTox_CID_2360 | DSSTox_GSID_22360 | DSSTox_RID_76556 |
| DTXSID9022360 | EC 205-426-2 | EINECS 205-426-2 |
| FT-0616437 | HSDB 5411 | IOY9FVU3J3 |
| ISAVYTVYFVQUDY-UHFFFAOYSA-N | InChI=1/C14H22O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11/h6-9,15H,10H2,1-5H; | J-523827 |
| KS-00000Z9J | KSC491S6L | LS-105148 |
| MCULE-1575585247 | MFCD00002368 | NCGC00164127-01 |
| NCGC00164127-02 | NCGC00164127-03 | NCGC00164127-04 |
| NCGC00164127-05 | NCGC00164127-06 | NCGC00164127-07 |
| NCGC00181157-01 | NE10184 | NSC 5427 |
| NSC-5427 | NSC-7248 | NSC5427 |
| NSC7248 | Octylphenol pt | P-T-Octylphenol |
| Phenol, 4-(1,1,3,3-tetramethylbutyl)- | Phenol, p-(1,1,3,3-tetramethylbutyl)- | Phenol, p-(tert-octyl)- |
| Q15632771 | RTR-005279 | SBB008090 |
| SCHEMBL10141 | SR-01000944308 | SR-01000944308-2 |
| ST24042806 | ST50828074 | STK594853 |
| TR-005279 | Tox21_112084 | Tox21_112084_1 |
| Tox21_400011 | Tyloxapol | UNII-IOY9FVU3J3 |
| VS-08533 | W-108198 | WLN: QR DX1 & 1 & 1X1 & 1 & 1 |
| ZINC1686938 | p-(1',1',3', 3'-Tetramethylbutyl)phenol | p-(1',1',3',3'-Tetramethylbutyl)fenol |
| p-(1',1',3',3'-Tetramethylbutyl)phenol | p-(1',3',3'-Tetramethylbutyl)phenol | p-(1,1,3,3-Tetramethylbutyl)phenol |
| p-(1,1,3,3-tetramethylbutyl)-phenol | p-(1,3,3-Tetramethylbutyl)phenol | p-(Tert-octyl)-Phenol |
| p-(tert-octyl)phenol | p-Octylphenol (VAN) | p-Terc.oktylfenol |
| p-Terc.oktylfenol(Czech) | p-terc.Oktylfenol [Czech] | p-tert-Octylphenol |
| p-tert.-octylphenol | para-tert-Octylphenol | para-tert.-octyl phenol |
| tert-Octylphenol, flaked |