D0732 | 4-chlorophenyl isocyanate
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 0.27±0.11 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 0.71 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 1.56±0.39 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
     |
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H315: Causes skin irritation [Warning Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P261, P264, P270, P271, P273, P280, P284, P285, P301+P312, P302+P352, P304+P340, P304+P341, P305+P351+P338, P310, P312, P320, P321, P330, P332+P313, P342+P311, P362, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 90 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (34.44%): Toxic if swallowed [Danger Acute toxicity, oral] H302 (65.56%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H330 (95.56%): Fatal if inhaled [Danger Acute toxicity, inhalation] H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H400 (72.22%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (72.22%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] H412 (27.78%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P261, P264, P270, P271, P273, P280, P284, P285, P301+P310, P301+P312, P302+P352, P304+P340, P304+P341, P305+P351+P338, P310, P312, P320, P321, P330, P332+P313, P342+P311, P362, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H315: Causes skin irritation [Warning Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P261, P264, P270, P271, P273, P280, P284, P285, P301+P312, P302+P352, P304+P340, P304+P341, P305+P351+P338, P310, P312, P320, P321, P330, P332+P313, P342+P311, P362, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LC50 | inhalation | 113mg/m3/4H (113mg/m3) | National Technical Information Service. Vol. OTS0555462, | |
| rabbit | LDLo | skin | 6gm/kg (6000mg/kg) | National Technical Information Service. Vol. OTS0528442, | |
| mouse | LD50 | oral | 450mg/kg (450mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 38, 1982. | |
| rat | LD | skin | > 1gm/kg (1000mg/kg) | National Technical Information Service. Vol. OTS0538092, | |
| rat | LDLo | intraperitoneal | 62500ug/kg (62.5mg/kg) | National Technical Information Service. Vol. OTS0538092, | |
| rat | LD50 | oral | 138mg/kg (138mg/kg) | National Technical Information Service. Vol. OTS0528437, | |
| mammal (species unspecified) | LC50 | inhalation | 53mg/m3 (53mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(4), Pg. 23, 1967. | |
| man | TCLo | inhalation | 800ug/m3/1M (0.8mg/m3) | Hygiene and Sanitation Vol. 31(7-9), Pg. 481, 1966. | |
| mouse | LC50 | inhalation | 53mg/m3 (53mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(9), Pg. 108, 1966. | |
| 1-Chloro-4-isocyanatobenzene | 1-chloranyl-4-isocyanato-benzene | 1-chloro-4 isocyanato-benzene |
| 1-chloro-4-isocyanato-benzen | 1-chloro-4-isocyanato-benzene | 1-chloro-4-isocyanatobenzen |
| 104-12-1 | 137131-EP2286811A1 | 137131-EP2292606A1 |
| 4-Chloro-iso-cyanatobenzene | 4-Chloroisocyanatobenzene | 4-Chlorophenyl isocyanate |
| 4-Chlorophenyl isocyanate, 98% | 4-Chlorophenylisocyanate | 4-Isocyanato chlorobenzene |
| 4-chiorophenyl isocyanate | 4-chloro phenyl isocyanate | 4-chloro phenylisocyanate |
| 4-chloro-1-isocyanato benzene | 4-chloro-1-isocyanato-benzene | 4-chloro-phenyl isocyanate |
| 4-chloro-phenylisocyanate | 4-chlorobenzenisocyanate | 4-chlorophenyl -isocynate |
| 4-chlorophenyl isocynate | 4-chlorophenyl-isocyanate | A800902 |
| AB1003315 | ACMC-2098b0 | ADAKRBAJFHTIEW-UHFFFAOYSA-N |
| AKOS000121897 | ANW-15034 | BBL012220 |
| BCP29164 | Benzene, 1-chloro-4-isocyanato- | CAS-104-12-1 |
| CHEMBL1865294 | CTK3J0089 | DB-014008 |
| DSSTox_CID_20732 | DSSTox_GSID_40732 | DSSTox_RID_79577 |
| DTXSID7040732 | EC 203-176-9 | EINECS 203-176-9 |
| F2190-0546; | FT-0631566 | FT-0650417 |
| FT-0686388 | HSDB 1331 | I0121 |
| ISOCYANIC ACID, P-CHLOROPHENYL ESTER | Isocyanic Acid 4-Chlorophenyl Ester | KS-00000EMG |
| KSC490A8T | LS-84439 | MCULE-8599901017 |
| MFCD00002024 | NCGC00164343-01 | NCGC00164343-02 |
| NCGC00254893-01 | NSC 76589 | NSC-76589 |
| NSC76589 | PCPI | Q26840784 |
| RT-001453 | SBB058877 | SC-26481 |
| SCHEMBL77660 | ST50824415 | STL163561 |
| TRA0050202 | Tox21_300991 | UNII-W46XL60WI8 |
| VS-03241 | W-108825 | W46XL60WI8 |
| WLN: OCNR DG | ZINC1707960 | p- chlorophenylisocyanate |
| p-Chlorfenylisokyanat | p-Chlorfenylisokyanat [Czech] | p-Chlorophenyl isocyanate |
| p-chloro phenylisocyanate | p-chlorophenylisocvanate | p-chlorophenylisocyanate |
| p-chlorphenyl isocyanate | para-Chlorophenyl isocyanate |
| CAS Number | 104-12-1 |
| PubChem Compound | 7693 |