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Drug

D0762 | 9-phenanthrol

Molecular Formula C14H10O
Molecular Weight 194.23
Structure
State solid
Volume of distribution The volume of distribution at steady-state appeared to be significantly dose dependent: 78 ml/kg for doses < or = 20 microg/kg and 88 ml/kg for doses > 20 microg/kg respectively
Route of elimination Mostly via the kidney as metabolites
Protein binding 98.7% protein bound, mainly to albumin
Half life 8 to 11 hours.
Absorption Rapidly absorbed orally with greater than 60% bioavailability. Peak plasma levels are attained 1 to 3 hours following oral administration.

B

B01AA07 Acenocoumarol


[B01AA] Vitamin K antagonists


[B01A] ANTITHROMBOTIC AGENTS


[B01] ANTITHROMBOTIC AGENTS


[B] Blood and blood forming organs

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 1.22±0.56 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 3.55 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 47.28±10.66 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 4-06-00-04937 (Beilstein Handbook Reference) 484-17-3 484H173
    6618AB 9-Hydroxyphenanthrene 9-PHENANTHROL
    9-Phenanthrenol 9-Phenanthrol, technical grade 9FYU45OV9H
    ACMC-1AD67 AKOS015856392 ANW-63236
    AX8015175 B7728 BRN 2047057
    C-08720 C11430 CAS-484-17-3
    CC-23562 CCRIS 1840 CHEBI:28820
    CHEMBL2407182 CTK1D6170 DB-022746
    DSSTox_CID_27592 DSSTox_GSID_47592 DSSTox_RID_82439
    DTXSID9047592 DZKIUEHLEXLYKM-UHFFFAOYSA- DZKIUEHLEXLYKM-UHFFFAOYSA-N
    EINECS 207-602-4 FT-0632197 GTPL4114
    InChI=1/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H; J-519521 KS-000018CG
    LS-102950 NCGC00248109-01 NCGC00254471-01
    NSC 50554 NSC-50554 NSC50554
    Phenanthren-9-ol Q24063303 SCHEMBL508755
    ST50825370 TP-0037 TRA0072148
    Tox21_300618 UNII-9FYU45OV9H ZINC967824
    phenanthrene-9-ol

    DrugBank DB01418
    CAS Number 106-34-3, 484-17-3, 5103-83-3, 84-17-3
    PubChem Compound 10229
    KEGG Compound ID C11430
    ChEBI 28820