MITOTOX

Drug

D0769 | allylestrenol

Properties

Molecular Formula	C21H32O
Molecular Weight	300.5
Structure
State	solid
Route of elimination	The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces. Progesterone metabolites are excreted mainly by the kidneys.

Therapeutic Classification Source: DrugBank

G03DC01 Allylestrenol

[G03DC] Estren derivatives

[G03D] PROGESTOGENS

[G03] SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM

[G] Genitourinary system and reproductive hormones

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	12.83±3.68	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	31.62	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL		rat	hepatocytes	MMP assay	Negative	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Warning	Aggregated GHS information provided by 19 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (94.74%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (89.47%): Harmful in contact with skin [Warning Acute toxicity, dermal] H332 (94.74%): Harmful if inhaled [Warning Acute toxicity, inhalation] H351 (89.47%): Suspected of causing cancer [Warning Carcinogenicity] H361 (94.74%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Warning

Aggregated GHS information provided by 19 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (94.74%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (89.47%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H332 (94.74%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H351 (89.47%): Suspected of causing cancer [Warning Carcinogenicity]

H361 (94.74%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

(17beta)-17-prop-2-en-1-ylestr-4-en-17-ol	17-(2-Propenyl)estr-4-en-17-ol	17-Hydroxy-17-alpha-allyl-4-estrene
17-allylestr-4-en-17-beta-ol	17-alpha-Allyl-17-beta-hydroxy-4-estrene	17-alpha-Allyl-17-beta-hydroxy-delta(sup 4)-estren
17-alpha-Allyl-3-deoxy-19-nortestosterone	17-alpha-Allyl-4-oestrene-17-beta-ol	17-alpha-Allylestr-4-en-17-beta-ol
17-alpha-Allylhydroxy-19-nor-4-androstene	17.alpha.-Allyl-17-.beta.-hydroxy-.delta.(sup 4)-estren	17.alpha.-Allyl-17.beta.-hydroxy-4-estrene
17.alpha.-Allyl-3-deoxy-19-nortestosterone	17.alpha.-Allyl-4-destrene-17.beta.-ol	17.alpha.-Allyl-4-estren-17.beta.-ol
17.alpha.-Allyl-4-oestrene-17.beta.-ol	17.alpha.-Allylestr-4-en-17.beta.-ol	17.alpha.-Allylestrenol
17alpha-Allyl-17beta-hydroxy-4-estrene	17alpha-Allyl-19-nor-delta-4-androstene-17beta-ol	17alpha-Allyl-3-deoxy-19-nortestosterone
17alpha-Allyl-4-destrene-17beta-ol	17alpha-Allyl-4-estren-17beta-ol	17alpha-Allyl-4-oestrene-17beta-ol
17alpha-Allylestr-4-en-17beta-ol	17alpha-Allylestrenol	19-Nor-17-alpha-preg-4-en-17-ol, 21-methylene-
19-norpregn-4-ene-20-yn-17beta-ol	21-Methylene-19-nor-17-alpha-preg-4-en-17-ol	3-Deoxy-17-alpha-allyl-19-nortestosterone
3-deketo-17alpha-allyl-19-nortestosterone	4-06-00-04143 (Beilstein Handbook Reference)	432-60-0
432A600	A-8648	AKOS015964938
Alilestrenol	Alilestrenol [INN-Spanish]	Allilestrenolo
Allilestrenolo [DCIT]	Allyl estrenol	Allylestrenol (JAN/INN)
Allylestrenol [INN:BAN:JAN]	Allylestrenol [INN:JAN]	Allylestrenolum
Allylestrenolum [INN-Latin]	Allyloestrenol	Allyloestrenolum
BCP10809	BRN 3148038	C-18772
C12811	CAS-432-60-0	CC-23894
CCRIS 9068	CHEBI:31189	CHEMBL3185133
CS-0006769	D01374	DB01431
DS-8255	DSSTox_CID_2574	DSSTox_GSID_22574
DSSTox_RID_76637	DTXSID9022574	EINECS 207-082-9
ESTR-4-EN-17-beta-OL, 17-ALLYL-	Estr-4-en-17-ol, (17.beta.)-	Estr-4-en-17-ol, 17-(2-propenyl)-, (17beta)-
Estr-4-en-17-ol, 17-(2-propenyl)-, (17beta)- (9CI);	Estr-4-en-17.beta.-ol, 17-allyl-	Estr-4-en-17beta-ol, 17-allyl-
Estr-4-en-17beta-ol, 17-allyl- (8CI)	Estrenol, allyl-	Gestanin
Gestanol	Gestanon	Gestanon-r
Gestanyn	HY-17375	I47VB5DZ8O
LMST02030125	LS-64837	NCGC00159497-02
NSC 37723	NSC-37723	NSC37723
Orageston	Organon	Perselin (TN)
PubChem21334	Q531965	SCHEMBL329623
SR-01000883956	SR-01000883956-1	ST24045936
Tox21_111718	Turinal	UNII-I47VB5DZ8O
VA10231	WLN: L E5 B666 MUTJ E1 FQ F2U1	ZINC4214767
allylestrenol

External IDs

DrugBank Name	allylestrenol
DrugBank	DB01431
CAS Number	432-60-0, 5427-36-1
PubChem Compound	235905
KEGG Compound ID	C12811
KEGG Drug	D01374
ChEBI	31189