MITOTOX

Drug

D0776 | amorolfine

D01AE16 Amorolfine

[D01AE] Other antifungals for topical use

[D01A] ANTIFUNGALS FOR TOPICAL USE

[D01] ANTIFUNGALS FOR DERMATOLOGICAL USE

[D] Dermatological drugs

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	21.61±3.47	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	17.34	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL		rat	hepatocytes	MMP assay	Negative	IC50	163

(+-)-cis-2,6-Dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine	(+/-)-cis-2,6-dimethyl-4-[2-methyl-3-(p-t-pentylphenyl)propyl]-morpholin	(2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine
(2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine	(2S,6R)-2,6-dimethyl-4-(2-methyl-3-(4-tert-pentylphenyl)propyl)morpholine	(2S,6R)-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methyl-propyl]-2,6-dimethyl-morpholine;
106614-68-0	613A351	67467-83-8
78613-35-1	A839459	AB01274715-01
AB01274715-02	AB01274715_03	AB01274715_04
AC-1982	AKOS015896221	Amorolfina
Amorolfine	Amorolfine (USAN/INN)	Amorolfine-Hydrochloride
Amorolfinum	C-19530	CAS-78613-35-1
CC-24100	CHEBI:599440	CHEMBL489411
CTK5C6210	D02923	DB09056
DL-246	DSSTox_CID_26690	DSSTox_GSID_46690
DSSTox_RID_81824	DTXSID0046690	FT-0080245
FT-0601559	HMS2089I20	LS-176596
Loceryl	Loceryl (TN)	MQHLMHIZUIDKOO-AYHJJNSGSA-N
Morpholine, 4-(3-(4-(1,1-dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethyl-	NCGC00167524-01	NCGC00167524-02
NCGC00167524-03	Q123195	Ro 14-4767-002
Ro 14-4767/002	Ro-14-4767-002	Ro-144767000
SC-75124	SCHEMBL150666	SR-05000001441
SR-05000001441-1	TX-017422	Tox21_112521
Tox21_112521_1	amorolfin	cis-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine
meso-2,6-dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine	meso-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine