Drug

D0776 | amorolfine

Molecular Formula C21H35NO
Molecular Weight 317.5
Structure
State solid

D

D01AE16 Amorolfine


[D01AE] Other antifungals for topical use


[D01A] ANTIFUNGALS FOR TOPICAL USE


[D01] ANTIFUNGALS FOR DERMATOLOGICAL USE


[D] Dermatological drugs


Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 21.61±3.47 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 17.34 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163


  • (+-)-cis-2,6-Dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine (+/-)-cis-2,6-dimethyl-4-[2-methyl-3-(p-t-pentylphenyl)propyl]-morpholin (2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine
    (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine (2S,6R)-2,6-dimethyl-4-(2-methyl-3-(4-tert-pentylphenyl)propyl)morpholine (2S,6R)-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methyl-propyl]-2,6-dimethyl-morpholine;
    106614-68-0 613A351 67467-83-8
    78613-35-1 A839459 AB01274715-01
    AB01274715-02 AB01274715_03 AB01274715_04
    AC-1982 AKOS015896221 Amorolfina
    Amorolfine Amorolfine (USAN/INN) Amorolfine-Hydrochloride
    Amorolfinum C-19530 CAS-78613-35-1
    CC-24100 CHEBI:599440 CHEMBL489411
    CTK5C6210 D02923 DB09056
    DL-246 DSSTox_CID_26690 DSSTox_GSID_46690
    DSSTox_RID_81824 DTXSID0046690 FT-0080245
    FT-0601559 HMS2089I20 LS-176596
    Loceryl Loceryl (TN) MQHLMHIZUIDKOO-AYHJJNSGSA-N
    Morpholine, 4-(3-(4-(1,1-dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethyl- NCGC00167524-01 NCGC00167524-02
    NCGC00167524-03 Q123195 Ro 14-4767-002
    Ro 14-4767/002 Ro-14-4767-002 Ro-144767000
    SC-75124 SCHEMBL150666 SR-05000001441
    SR-05000001441-1 TX-017422 Tox21_112521
    Tox21_112521_1 amorolfin cis-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine
    meso-2,6-dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine meso-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine

    DrugBank Name amorolfine
    DrugBank DB09056
    CAS Number 106614-68-0, 67467-83-8, 78613-35-1, 78613-38-4
    PubChem Compound 54260
    KEGG Drug D02923
    ChEBI 599440