Drug
D0787 | bardoxolone methyl
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 5.11±1.27 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 17.34 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 17.41±2.00 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Warning |
Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Reported as not meeting GHS hazard criteria by 1 of 2 companies. For more detailed information, please visit ECHA C&L website Of the 1 notification(s) provided by 1 of 2 companies with hazard statement code(s): H371 (100%): May cause damage to organs [Warning Specific target organ toxicity, single exposure] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P264, P270, P309+P311, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| (+)-methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate | (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate | (4aS,6aR,6bS,8aR,12aS,14bS)-Methyl 11-cyano-2,2,6a,6b,9,9,12a-he |
| 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid methyl ester | 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid methyl ester | 218600-53-4 |
| AC-26830 | ACN-035790 | AKOS025401880 |
| AOB1215 | BCP04660 | BDBM217379 |
| Bardoxolone (methyl) | Bardoxolone Methyl (CDDO-Me) | Bardoxolone methyl |
| Bardoxolone methyl (JAN/USAN) | Bardoxolone methyl RTA 402 | Bardoxolone methyl [USAN] |
| Bardoxolone methyl ester | CAS-218600-53-4 | CDDO Methyl Ester, >=98% (HPLC) |
| CDDO Methyl ester | CDDO methyl ester | CDDO-Me |
| CDDO-Me, 2 | CDDO-Methyl ester | CEG1Q6OGU1 |
| CHEMBL1762621 | CS-0598 | CSA:218600-53-4;Bardoxolone methyl |
| D09585 | DB05983 | DSSTox_CID_28690 |
| DSSTox_GSID_48764 | DSSTox_RID_82960 | DTXSID5048764 |
| GTPL3443 | HY-13324 | NCGC00186460-01 |
| NSC 713200 | NSC 713200 | NSC-713200 |
| NSC713200 | Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester | Q4860208 |
| RTA 402 | RTA 402 | RTA-402 |
| RTA-402|||NSC-713200|||CDDO methyl ester|||2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid methyl ester; | RTA402 | SCHEMBL12521530 |
| TP-155 | Tox21_113229 | UNII-CEG1Q6OGU1 |
| WPTTVJLTNAWYAO-KPOXMGGZSA-N | ZINC3982151 | bardoxolone-methyl |
| methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylate | methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate | methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate |
| methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate | s8078 |
| DrugBank Name | bardoxolone methyl |
| DrugBank | DB05983 |
| CAS Number | 218600-53-4, 21980-07-4 |
| PubChem Compound | 400769 |
| KEGG Drug | D09585 |