Compound
D0792 | beclazone
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 23.71±2.74 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 21.82 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 16.28±20.57 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Danger |
Aggregated GHS information provided by 89 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H360 (91.01%): May damage fertility or the unborn child [Danger Reproductive toxicity] H373 (46.07%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P260, P281, P308+P313, P314, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rabbit | LD | subcutaneous | > 750mg/kg (750mg/kg) | Yamaguchi Igaku. Yamaguchi Medicine. Vol. 19, Pg. 65, 1970. | |
| rat | LC50 | inhalation | > 51600ug/m3/2 (51.6mg/m3) | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 2, Pg. 97, 1976. | |
| rat | LD50 | subcutaneous | > 1500mg/kg (1500mg/kg) | skin and appendages (skin): "dermatitis, other: after systemic exposure" | Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 863, 1976. |
| rat | LD50 | intraperitoneal | > 3gm/kg (3000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 863, 1976. | |
| mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. 746, 1982. | |
| rat | LD50 | oral | > 3750mg/kg (3750mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 863, 1976. | |
| mouse | LDLo | intraperitoneal | 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1037, 1971. | |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. 746, 1982. | |
| (11beta,16beta)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione | (11beta,16beta)-9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate | 2-[(1R,2S,10S,11S,13S,14R,15S,17S)-1-chloro-17-hydroxy-2,13,15-trimethyl-5-oxo-14-(propanoyloxy)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoate |
| 32278-EP2281815A1 | 32278-EP2295408A1 | 32278-EP2301933A1 |
| 32278-EP2305640A2 | 32278-EP2311827A1 | 534B098 |
| 5534-09-8 | 5B307S63B2 | 9-Chloro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate |
| 9-Chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate | 9-Chloro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate | 9-Chloro-11|A,17,21-trihydroxy-16|A-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate |
| 9-chloro-16beta-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionate | 9alpha-chloro-16beta-methyl-3,20-dioxo-1,4-pregnadiene-11beta,17,21-triol 17,21-dipropionate | AB1009261 |
| AC-2159 | AKOS015951275 | API0001601 |
| Aerobec | Alanase | Aldecin |
| Aldecina | Aldecine | Anceron |
| Atomase | B4464 | BECLOMETHASONE DIPROPIONATE |
| BPBio1_000957 | BRD-K97810537-001-03-7 | BRD-K97810537-001-13-6 |
| BSPBio_000869 | Beclacin | Beclate |
| Beclazone | Beclazone 250 | Beclocort Nasel |
| Becloforte | Beclomet | Beclomet Nasal |
| Beclometasone (beclomethasone) dipropionate, British Pharmacopoeia (BP) Assay Standard | Beclometasone 17,21-dipropionate | Beclometasone dipropionate |
| Beclometasone dipropionate (JP17) | Beclometasone dipropionate for peak identification, European Pharmacopoeia (EP) Reference Standard | Beclometasone dipropionate for system suitability, European Pharmacopoeia (EP) Reference Standard |
| Beclometasone dipropionato | Beclomethasone Dipropionate, Pharmaceutical Secondary Standard | Beclomethasone dipropionate (USP) |
| Beclomethasone dipropionate [USAN:USP] | Beclomethasone dipropionate [USAN] | Beclomethasone dipropionate, United States Pharmacopeia (USP) Reference Standard |
| Beclomethasone dipropionate, analytical standard, for drug analysis | Beclomethasone dipropionate, anhydrous, European Pharmacopoeia (EP) Reference Standard | Beclorhinol |
| Becloturmant | Becloval | Beclovent |
| Beclovent (TN) | Becodisks | Beconase |
| Beconase AQ | Beconasol | Becotide |
| Benconase | C07813 | C28H37ClO7 |
| CAS-5534-09-8 | CCG-220855 | CHEBI:3002 |
| CHEMBL1200500 | CPD001233361 | CS-1503 |
| CTK8F7938 | Certified Reference Material | Clenil |
| Clenil-A | D00689 | DB00394 |
| DSSTox_CID_28656 | DSSTox_GSID_48730 | DSSTox_RID_82926 |
| DTXSID3048730 | EINECS 226-886-0 | Entyderma |
| GTPL5894 | HMS1570L11 | HMS2097L11 |
| HMS2235O23 | HMS3259H03 | HMS3714L11 |
| HY-13571A | Inalone | Inalone O |
| Inalone R | KUVIULQEHSCUHY-XYWKZLDCSA-N | KW-053 |
| Korbutone | LS-118439 | MFCD00135613 |
| MLS002154034 | Menaderm | NC00610 |
| NCGC00094596-03 | NCGC00179392-01 | Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11.beta.,16.beta.)- |
| Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11beta,16beta)- | Pregna-1,4-diene-3,20-dione, 9-chloro-16-beta-methyl-11-beta,17,21-trihydroxy-, 17,21-dipropionate | Pregna-1-4-diene-3,20-dione, 9-chloro-16-beta-methyl-11-beta,17,21-trihydroxy-,17,21-dipropionate; |
| Prestwick0_000855 | Prestwick1_000855 | Prestwick2_000855 |
| Prestwick3_000855 | Prestwick_990 | Propaderm |
| Propaderm Forte | Propionic acid beclomethasone | Q421475 |
| QNASL | QVAR 40 | Qnasl (TN) |
| Qvar | Qvar 80 | Respocort |
| Rhino Clenil | Rhinosol | Rino-clenil |
| SCH 18020W | SCH 8020W | SCHEMBL6890 |
| SGX-201 | SGX-202 | SGX-203 |
| SMR001233361 | SPBio_002790 | ST24046007 |
| Sanasthmax | Sanasthmyl | Spir |
| Tox21_113168 | Turbinal | UNII-5B307S63B2 |
| Vancenase | Vanceril | Vanceril (TN) |
| Vanceril Double Strength | Ventolair | Viarex |
| Viarox | W-5080 | ZINC3938744 |
| [(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate | [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate | beclomethasone dipropionate anhydrous |
| beclomethasone-dipropionate | s3078 |