Compound

D0792 | beclazone

Molecular Formula C28H37ClO7
Molecular Weight 521
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 23.71±2.74 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 21.82 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 16.28±20.57 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 89 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H360 (91.01%): May damage fertility or the unborn child [Danger Reproductive toxicity]


H373 (46.07%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P260, P281, P308+P313, P314, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LD subcutaneous > 750mg/kg (750mg/kg) Yamaguchi Igaku. Yamaguchi Medicine. Vol. 19, Pg. 65, 1970.
rat LC50 inhalation > 51600ug/m3/2 (51.6mg/m3) Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 2, Pg. 97, 1976.
rat LD50 subcutaneous > 1500mg/kg (1500mg/kg) skin and appendages (skin): "dermatitis, other: after systemic exposure" Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 863, 1976.
rat LD50 intraperitoneal > 3gm/kg (3000mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 863, 1976.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) Drugs in Japan Vol. 6, Pg. 746, 1982.
rat LD50 oral > 3750mg/kg (3750mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 863, 1976.
mouse LDLo intraperitoneal 2gm/kg (2000mg/kg) Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1037, 1971.
mouse LD50 oral > 5gm/kg (5000mg/kg) Drugs in Japan Vol. 6, Pg. 746, 1982.


  • (11beta,16beta)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11beta,16beta)-9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate 2-[(1R,2S,10S,11S,13S,14R,15S,17S)-1-chloro-17-hydroxy-2,13,15-trimethyl-5-oxo-14-(propanoyloxy)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoate
    32278-EP2281815A1 32278-EP2295408A1 32278-EP2301933A1
    32278-EP2305640A2 32278-EP2311827A1 534B098
    5534-09-8 5B307S63B2 9-Chloro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
    9-Chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate 9-Chloro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate 9-Chloro-11|A,17,21-trihydroxy-16|A-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
    9-chloro-16beta-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionate 9alpha-chloro-16beta-methyl-3,20-dioxo-1,4-pregnadiene-11beta,17,21-triol 17,21-dipropionate AB1009261
    AC-2159 AKOS015951275 API0001601
    Aerobec Alanase Aldecin
    Aldecina Aldecine Anceron
    Atomase B4464 BECLOMETHASONE DIPROPIONATE
    BPBio1_000957 BRD-K97810537-001-03-7 BRD-K97810537-001-13-6
    BSPBio_000869 Beclacin Beclate
    Beclazone Beclazone 250 Beclocort Nasel
    Becloforte Beclomet Beclomet Nasal
    Beclometasone (beclomethasone) dipropionate, British Pharmacopoeia (BP) Assay Standard Beclometasone 17,21-dipropionate Beclometasone dipropionate
    Beclometasone dipropionate (JP17) Beclometasone dipropionate for peak identification, European Pharmacopoeia (EP) Reference Standard Beclometasone dipropionate for system suitability, European Pharmacopoeia (EP) Reference Standard
    Beclometasone dipropionato Beclomethasone Dipropionate, Pharmaceutical Secondary Standard Beclomethasone dipropionate (USP)
    Beclomethasone dipropionate [USAN:USP] Beclomethasone dipropionate [USAN] Beclomethasone dipropionate, United States Pharmacopeia (USP) Reference Standard
    Beclomethasone dipropionate, analytical standard, for drug analysis Beclomethasone dipropionate, anhydrous, European Pharmacopoeia (EP) Reference Standard Beclorhinol
    Becloturmant Becloval Beclovent
    Beclovent (TN) Becodisks Beconase
    Beconase AQ Beconasol Becotide
    Benconase C07813 C28H37ClO7
    CAS-5534-09-8 CCG-220855 CHEBI:3002
    CHEMBL1200500 CPD001233361 CS-1503
    CTK8F7938 Certified Reference Material Clenil
    Clenil-A D00689 DB00394
    DSSTox_CID_28656 DSSTox_GSID_48730 DSSTox_RID_82926
    DTXSID3048730 EINECS 226-886-0 Entyderma
    GTPL5894 HMS1570L11 HMS2097L11
    HMS2235O23 HMS3259H03 HMS3714L11
    HY-13571A Inalone Inalone O
    Inalone R KUVIULQEHSCUHY-XYWKZLDCSA-N KW-053
    Korbutone LS-118439 MFCD00135613
    MLS002154034 Menaderm NC00610
    NCGC00094596-03 NCGC00179392-01 Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11.beta.,16.beta.)-
    Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11beta,16beta)- Pregna-1,4-diene-3,20-dione, 9-chloro-16-beta-methyl-11-beta,17,21-trihydroxy-, 17,21-dipropionate Pregna-1-4-diene-3,20-dione, 9-chloro-16-beta-methyl-11-beta,17,21-trihydroxy-,17,21-dipropionate;
    Prestwick0_000855 Prestwick1_000855 Prestwick2_000855
    Prestwick3_000855 Prestwick_990 Propaderm
    Propaderm Forte Propionic acid beclomethasone Q421475
    QNASL QVAR 40 Qnasl (TN)
    Qvar Qvar 80 Respocort
    Rhino Clenil Rhinosol Rino-clenil
    SCH 18020W SCH 8020W SCHEMBL6890
    SGX-201 SGX-202 SGX-203
    SMR001233361 SPBio_002790 ST24046007
    Sanasthmax Sanasthmyl Spir
    Tox21_113168 Turbinal UNII-5B307S63B2
    Vancenase Vanceril Vanceril (TN)
    Vanceril Double Strength Ventolair Viarex
    Viarox W-5080 ZINC3938744
    [(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate beclomethasone dipropionate anhydrous
    beclomethasone-dipropionate s3078

    CAS Number 34135-07-4, 4419-39-0, 5534-09-8
    PubChem Compound 21700
    ChEBI 3002