Drug
D0795 | benziodarone
C
C01DX54 Benziodarone, combinations
[C01DX] Other vasodilators used in cardiac diseases
[C01D] VASODILATORS USED IN CARDIAC DISEASES
[C01] CARDIAC THERAPY
[C] Cardiovascular system
C01DX04 Benziodarone
[C01DX] Other vasodilators used in cardiac diseases
[C01D] VASODILATORS USED IN CARDIAC DISEASES
[C01] CARDIAC THERAPY
[C] Cardiovascular system
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 2.98±0.63 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 4.35 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 1.76±0.68 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Danger |
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] |
P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 130mg/kg (130mg/kg) | Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973. | |
| dog | LDLo | intravenous | 10mg/kg (10mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 1388, 1965. | |
| mouse | LD50 | oral | 450mg/kg (450mg/kg) | Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973. | |
| (2-Ethyl-1-benzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone # | (2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone | 2-Ethyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)-cumarone |
| 2-Ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl ketone | 2-Ethylbenzofuranyl 4-hydroxy-3,5-diiodophenyl ketone | 2-ethyl-3-benzofuranyl-4-hydroxy-3,5-diiodophenyl ketone |
| 2329 Labaz | 3,5-Diiodo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl ketone | 68-90-6 |
| 75CL65GTYR | AKOS015994715 | API0010003 |
| Aethyl-2-(3',5'-dijod-4'-oxybenzoyl)-3 cumaron | Aethyl-2-(3',5'-dijod-4'-oxybenzoyl)-3 cumaron [German] | Algocor |
| Amplivix | Amplivix (TN) | BDBM50209206 |
| BENZIODARONE | BRN 1257683 | Benziodaron |
| Benziodarona | Benziodarona [INN-Spanish] | Benziodarone (JAN/INN) |
| Benziodarone [INN:BAN:DCF:JAN] | Benziodarone [INN:BAN:DCF] | Benziodaronum |
| Benziodaronum [INN-Latin] | Benzofuran, 3-(3,5-diiodo-4-hydroxybenzoyl)-2-ethyl- | Benzoiodarone |
| C-23788 | C17H12I2O3 | CAS-68-90-6 |
| CC-24335 | CHEBI:135814 | CHEMBL232201 |
| CZCHIEJNWPNBDE-UHFFFAOYSA-N | Cardivix | Carofam |
| Corofam | Coronal-crinos | D01833 |
| DB13277 | DSSTox_CID_26134 | DSSTox_GSID_46134 |
| DSSTox_RID_81367 | DTXSID1046134 | Dila-Vasal |
| Dilacoron | Dilafurane | EINECS 200-695-2 |
| FT-0662545 | Flanicone | KS-1133 |
| Ketone, 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl | Ketone, 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl (8CI) | Ketone, 3,5-diiodo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl |
| Ketone,5-diiodophenyl | L 2329 | LS-87146 |
| Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)- | Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)- (9CI); | Methanone,5-diiodophenyl)- |
| NCGC00160408-01 | NCGC00160408-02 | NCGC00160408-03 |
| NSC 82133 | NSC-82133 | NSC82133 |
| Plexocardio | Q4890775 | Retrangor |
| SCHEMBL308541 | Tox21_111793 | Tox21_111793_1 |
| UNII-75CL65GTYR | Uricor | ZINC3875456 |
| DrugBank Name | benziodarone |
| DrugBank | DB13277 |
| CAS Number | 68-90-6 |
| PubChem Compound | 6237 |
| KEGG Drug | D01833 |
| ChEBI | 31265 |