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2021 MitoTox | (CC BY-NC 4.0)
Drug

D0801 | berberine chloride

Molecular Formula C20H18ClNO4
Molecular Weight 371.8
Structure
State solid

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 2.03±1.29 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 3.46 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 6.03±3.78 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


 P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 16,17-dimethoxy-5,7-dioxa-13lambda5-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,13,15(20),16,18-octaen-13-ylium chloride; 5,6-Dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium chloride hydrate 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride
    633-65-8 9,10-dimethoxy-5,6-dihydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinol ine, chloride 9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride
    AB1009372 AC-118 AI3-61834
    AK323614 AKOS007930622 API0001672
    B0450 BERBERINE CHLORIDE (BERBARINE(2086-73-1)) Barberry Root Extract
    Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride (1:1) Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride (1:1)
    Benzo[g]-1,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride Benzodioxide Berberin hydrochloride
    Berberine (chloride) Berberine Chloride, Pharmaceutical Secondary Standard Berberine HCl
    Berberine Hydrochloride Hydrate Berberine Hydrochloride,(S) Berberine chloride (TN)
    Berberine chloride [JAN] Berberine chloride form Berberine chloride hydrate, technical, >=90% (AT)
    Berberine chloride, British Pharmacopoeia (BP) Reference Standard Berberine chloride, European Pharmacopoeia (EP) Reference Standard Berberine chloride, United States Pharmacopeia (USP) Reference Standard
    Berberine chloride, primary pharmaceutical reference standard Berberine hydrochloride Berberine-Hydrochloride
    Berberinium chloride Berberinium chloride hydrate Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, chloride
    Berbinium,8,13,13a-tetradehydro-9.10-dimethoxy-2,3-(methylene dioxy)-, chloride C-58382 C12679
    C20H18NO4.Cl CAS-633-65-8 CAS: 638-65-8
    CB0176 CCG-39622 CCRIS 8656
    CHEBI: 16118 CHEBI:31271 CHEMBL12089
    CS-3214 Certified Reference Material DSSTox_CID_4602
    DSSTox_GSID_24602 DSSTox_RID_77465 DTXSID8024602
    EINECS 211-195-9 FT-0622874 GNF-PF-4545
    HMS1569F14 HMS1921I18 HMS2096F14
    HMS2210A06 HMS2235H16 HMS3336C05
    HMS3373L14 HMS3655F20 HMS500N07
    HY-18258 KS-00000JKS KS-5294
    LS-1524 MCULE-7356741555 MFCD00011939
    MLS002153890 MLS002702530 N1699
    NCGC00016526-02 NCGC00016526-07 NCGC00091896-01
    NCGC00094858-01 NCGC00094858-02 NCGC00257902-01
    NSC 163088 NSC 646666 NSC-163088
    NSC-646666 NSC-757795 NSC163088
    NSC646666 NSC757795 Natural Yellow 18
    Pharmakon1600-01500811 Prestwick_91 Q-100261
    Q-100731 SBB057562 SC-18366
    SCHEMBL153906 SMR001233240 SPECTRUM1500811
    SR-01000711827 SR-01000711827-4 SR-01000711827-6
    ST50308453 SW196403-2 Tox21_110474
    Tox21_110474_1 Tox21_200348 UNII-UOT4O1BYV8
    UOT4O1BYV8 VKJGBAJNNALVAV-UHFFFAOYSA-M Z2768724441
    berberine chloride dimethoxy[?] chloride s2271

    DrugBank DB04115
    CAS Number 141433-60-5, 2086-83-1, 33570-04-6, 633-65-8
    PubChem Compound 12456
    KEGG Compound ID C12679