D0812 | bosutinib
L
L01XE14 Bosutinib
[L01XE] Protein kinase inhibitors
[L01X] OTHER ANTINEOPLASTIC AGENTS
[L01] ANTINEOPLASTIC AGENTS
[L] Antineoplastic and immunomodulating agents
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 0.75±0.48 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 1.23 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 16.59±11.17 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Warning |
Aggregated GHS information provided by 42 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H319 (97.62%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H413 (90.48%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P273, P280, P305+P351+P338, P337+P313, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
Aggregated GHS information provided by 154 companies from 1 notifications to the ECHA C&L Inventory. H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| 1391063-17-4 | 3-Quinolinecarbonitrile, 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)- | 380843-75-4 |
| 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile | 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-[3-(4-methyl-piperazin-1-yl)propoxy]quinoline-3-carbonitrile |
| 4-(2,4-dichloro-5-methoxyphenylamino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile | 4-(3,5-Dichloro-4-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | 5018V4AEZ0 | 843B754 |
| A25014 | AB0008633 | AB01565836_03 |
| ABP000235 | AC-2413 | AK544289 |
| AKOS015902521 | AOB87309 | API0024729 |
| AS-11064 | BCP01782 | BCP9000446 |
| BCPP000318 | BDBM4552 | BOSULIF |
| BRD-K99964838-001-01-0 | BRD-K99964838-001-06-9 | Bosutinib |
| Bosutinib (SKI-606) | Bosutinib (SKI606) | Bosutinib (USAN) |
| Bosutinib - SKI-606 | Bosutinib [USAN:INN] | Bosutinib(SKI-606) |
| Bosutinib, >=98% (HPLC) | Bosutinib,SKI-606 | CCG-208129 |
| CHEBI:39112 | CHEMBL288441 | CS-0118 |
| D03252 | DB06616 | DB8 |
| EC 700-455-1 | EX-A391 | FT-0656231 |
| GTPL5710 | HMS2043A22 | HMS3244A03 |
| HMS3244A04 | HMS3244B03 | HMS3651C03 |
| HMS3743E09 | HY-10158 | J-519931 |
| K00615a | MFCD07367846 | MLS006011212 |
| NCGC00241107-01 | NCGC00241107-03 | NCGC00241107-05 |
| PB30881 | PF-5208763 | PubChem22404 |
| Q-200745 | Q-4427 | Q894611 |
| QCR-26 | S1014 | SC-23008 |
| SCHEMBL158390 | SK 606 | SK-606 |
| SK-I606 | SKI 606 | SKI 606 |
| SKI-606 | SKI-606;4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-[3-(4-methyl-piperazin-1-yl)-propoxy]-quinoline-3-carbonitrile; | SKI606 |
| SKI606 | SMR002530350 | SR-01000941572 |
| SR-01000941572-1 | SW220197-1 | SYN1025 |
| UBPYILGKFZZVDX-UHFFFAOYSA-N | UNII-5018V4AEZ0 | WAY-173606 |
| X4840 | ZINC22448983 |
| CAS Number | 1384969-66-7, 1391063-17-4, 380843-75-4 |
| PubChem Compound | 5328940 |
| ChEBI | 39112 |
| PharmGKB | PA166114906 |