D0830 | calcifediol
A
A11CC06 Calcifediol
[A11CC] Vitamin D and analogues
[A11C] VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
[A11] VITAMINS
[A] Alimentary tract and metabolism
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 5.82±0.47 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 12.27 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 14.21±9.57 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
Aggregated GHS information provided by 42 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301+H311 (90.48%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral acute toxicity, dermal] H301 (92.86%): Toxic if swallowed [Danger Acute toxicity, oral] H311 (90.48%): Toxic in contact with skin [Danger Acute toxicity, dermal] H330 (90.48%): Fatal if inhaled [Danger Acute toxicity, inhalation] H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P264, P270, P271, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P314, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 43 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H300 (95.35%): Fatal if swallowed [Danger Acute toxicity, oral] H310 (95.35%): Fatal in contact with skin [Danger Acute toxicity, dermal] H330 (93.02%): Fatal if inhaled [Danger Acute toxicity, inhalation] H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P304+P340, P310, P314, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-5-hydroxy-1,5-dimethyl-hexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol | (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol | (3S,5Z,14beta,17alpha)-9,10-secocholesta-5,7,10-triene-3,25-diol |
| (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol | (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol | (3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol |
| (3b,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-3,25-diol | (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol | (5E,7E)-9,10-Secocholesta-5,7,10(19)-triene-3beta,25-diol |
| (5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol | (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol | (5Z,7E)-9,10-Seco-5,7,10(19)-cholestatrien-3beta,25-diol |
| (?R,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-?,?,?,7a-tetramethyl-1H-indene-1-pentanol | (S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol | (S,Z)-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol |
| 19356-17-3 | 25(OH)D3 | 25-(OH)Vitamin D3 |
| 25-Hydroxy vitamin D3 | 25-Hydroxycholecalciferol | 25-Hydroxycholecalciferol monohydrate |
| 25-Hydroxycholecalciferol, >=98% (HPLC) | 25-Hydroxycholescalciferol | 25-Hydroxyvitamin D |
| 25-Hydroxyvitamin D3 monohydrate, >=99.0% (HPLC) | 25-Hydroxyvitamin D3 solution, 100 mug/mL in ethanol, 98% (CP) | 25-Hydroxyvitamin D3 solution, 100 mug/mL in ethanol, ampule of 1 mL, certified reference material |
| 25-Hydroxyvitamin D3 solution, 5 mug/mL in ethanol, 98% (CP) | 25-Hydroxyvitamin D3 solution, 5 mug/mL in ethanol, ampule of 1 mL, certified reference material | 25-Hydroxyvitamin D3 solution, 50 mug/mL in ethanol, 98% (CP) |
| 25-hydroxy-cholecalciferol | 25-hydroxyvitamin D3 | 25-hydroxyvitamin D3 / 25-hydroxycholecalciferol / calcidiol |
| 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL | 356C173 | 36149-00-5 |
| 5,6-cis-25-Hydroxyvitamin D3 | 5,6-trans-25-Hydroxycholescalciferol | 5,6-trans-9,10-Seco-5,7,10(19)-cholestatrien-3beta,25-diol |
| 63283-36-3 | 64719-49-9; | 9,10-Secocholesta-5,7,10(19)-triene-1,25-diol, (3.beta,.5Z,7E)- |
| 9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, (3beta,5Z,7E)- | 9,10-Secocholesta-5,7,10(19)-triene-3b,25-diol | 9,10-Secocholesta-5,7,10(19)-triene-3beta,25-diol |
| AB01275461-01 | AB01275461_02 | AB2000120 |
| ACT06833 | AKOS015965097 | B91135EC-8937-4D8B-A533-CCD82F33C1B0 |
| BCP9000472 | BCPP000306 | BML2-E02 |
| BRD-K77175907-001-01-5 | BSPBio_001411 | C01561 |
| CAS-19356-17-3 | CHEBI:17933 | CHEBI:94743 |
| CHEMBL1040 | CS-0800 | Calcidiol |
| Calcidiol;Didrogyl;Hidroferol | Calcifediol | Calcifediol [INN] |
| Calcifediol anhydrous | Calcifediol, European Pharmacopoeia (EP) Reference Standard | Calcifediol, United States Pharmacopeia (USP) Reference Standard |
| Calcifediolum | Calcifediolum [INN-Latin] | Calcifidiol |
| Calderol | Cholecalciferol, 25-hydroxy- | DB00146 |
| DM100 | DSSTox_CID_2721 | DSSTox_GSID_22721 |
| DSSTox_RID_76699 | DTXSID0022721 | Dedrogyl |
| Delakmin | Didrogyl | EINECS 242-990-9 |
| GTPL6921 | HMS1361G13 | HMS1791G13 |
| HMS1989G13 | HMS2089L21 | HMS3402G13 |
| HY-32351 | Hidroferol | Hy-D |
| IDI1_033881 | JWUBBDSIWDLEOM-DTOXIADCSA-N | LMST03020246 |
| MFCD00867077 | NCGC00161326-01 | NCGC00161326-04 |
| PubChem18824 | Q139307 | Rayaldee |
| Ro 8-8892 | Rovimix Hy-D | Ryaldee |
| SCHEMBL3296 | SR-05000001468 | SR-05000001468-1 |
| ST2407990 | Spectrum5_001931 | T0WXW8F54E |
| Tox21_111987 | U 32070E | U-32070E |
| UNII-T0WXW8F54E | Vitamin D, 25-hydroxy- | W-201718 |
| W-5159 | ZINC4474414 | s1469 |