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Drug

D0835 | cantharidin

Molecular Formula C10H12O4
Molecular Weight 196.2
Structure
Clearance Little pharmacodynamic and pharmacokinetic data regarding cantharidin in the human body currently exists; recruitment for First-Time-In-Human clinical trials regarding such information have been ongoing in 2018 [L2647]. There are however some studies regarding such data in animal models like beagle dogs [A32901].
Volume of distribution After oral or IP injection of (3)H-labeled cantharidin, high levels of radioactivity distributed to and were exhibited in the bile, kidney, liver, stomach, and tumor cells of ascites hepatoma-bearing mice [L2648]. Such distribution suggests the agent has an affinity for liver and tumor tissues [L2648]. Little pharmacodynamic and pharmacokinetic data regarding cantharidin in the human body currently exists; recruitment for First-Time-In-Human clinical trials regarding such information have been ongoing in 2018 [L2647]. There are however some studies regarding such data in animal models like beagle dogs [A32901].
Route of elimination It has been observed that absorbed cantharidin is excreted by the kidney [L2648]. Little pharmacodynamic and pharmacokinetic data regarding cantharidin in the human body currently exists; recruitment for First-Time-In-Human clinical trials regarding such information have been ongoing in 2018 [L2647]. There are however some studies regarding such data in animal models like beagle dogs [A32901].
Protein binding Little pharmacodynamic and pharmacokinetic data regarding cantharidin in the human body currently exists; recruitment for First-Time-In-Human clinical trials regarding such information have been ongoing in 2018 [L2647]. There are however some studies regarding such data in animal models like beagle dogs [A32901].
Half life Little pharmacodynamic and pharmacokinetic data regarding cantharidin in the human body currently exists; recruitment for First-Time-In-Human clinical trials regarding such information have been ongoing in 2018 [L2647]. There are however some studies regarding such data in animal models like beagle dogs [A32901].
Absorption Cantharidin is absorbed from the gastrointestinal tract, and, to a limited extent from the skin as well [L2648]. Little pharmacodynamic and pharmacokinetic data regarding cantharidin in the human body currently exists; recruitment for First-Time-In-Human clinical trials regarding such information have been ongoing in 2018 [L2647]. There are however some studies regarding such data in animal models like beagle dogs [A32901].

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 0.15±0.08 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 0.12 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 0.45±0.30 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 46 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]


H315 (95.65%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (95.65%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (93.48%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LDLo subcutaneous 1mg/kg (1mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
chicken LDLo subcutaneous 75mg/kg (75mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
dog LDLo oral 50mg/kg (50mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
mouse LD50 intraperitoneal 1mg/kg (1mg/kg) Journal of Agricultural and Food Chemistry. Vol. 35, Pg. 823, 1987.
pigeon LDLo oral 32mg/kg (32mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
mammal (species unspecified) LDLo oral 75mg/kg (75mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
mammal (species unspecified) LD50 intraperitoneal 1710ug/kg (1.71mg/kg) "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai Science/Technology Publisher,Peop. Rep. China, 1994Vol. -, Pg. 183, 1994.
rabbit LDLo oral 20mg/kg (20mg/kg) cardiac: arrhythmias (including changes in conduction) Toxicon. Vol. 23, Pg. 36, 1985.
cat LDLo oral 310mg/kg (310mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
mammal (species unspecified) LDLo unreported 50mg/kg (50mg/kg) Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 20, Pg. 135, 1989.
human LDLo oral 428ug/kg (0.428mg/kg) "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 646, 1969.
frog LDLo oral 7273mg/kg (7273mg/kg) "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.


  • (1R,2S,3R,6S)-1,2-Dimethyl-3,6-epoxycyclohexane-1,2-dicarboxylic anhydride (1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione (1R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
    (1S,2R,6S,7R)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione (1S,3S,4R,7R)-2,6-dimethyl-4,10-dioxa-tricyclo[5.2.1.0-2,6]decane-3,5-dione (3a?,4?,7?,7a?)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
    (3aR,4S,7R,7aS)-3a,7a-dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione (3ar,4s,7r,7as)-3a,7a-dimethylhexahydro-4,7-epoxy-2-benzofuran-1,3-dione 1,2-Dimethyl-3,6-epoxyperhydrophthalic anhydride
    1,6-epoxyperhydrophthalic anhydride 134C968 2,3-Dimethyl-7-oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride
    2,3-dicarboxylic anhydride 3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione 4,3-dione, hexahydro-3a,7a-dimethyl-
    4,3-dione, hexahydro-3a,7a-dimethyl-, (3a.alpha.,4.beta.,7.beta.,7a.alpha.)-; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl- 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3a-alpha,4-beta,7-beta,7a-alpha)
    4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3a.alpha.,4.beta.,7.beta.,7a.alpha.)- 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aR,4S,7R,7aS)-rel- 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aalpha,4beta,7beta,7aalpha)-
    5-19-05-00051 (Beilstein Handbook Reference) 56-25-7 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride, 2,3-dimethyl-
    7-Oxabicyclo[2.2.1]heptane-2, 2,3-dimethyl- 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran AB00513946
    AC-7967 ACT03236 AI3-04021
    AKOS015895930 API0001832 AS-18735
    BCP09819 BDBM50090505 BPBio1_000738
    BRD-K80684056-001-01-0 BRN 0085302 BSPBio_000670
    C16778 CAN [Alkaloid] CANTHARIDINE
    CAS-56-25-7 CCG-35382 CCG-36082
    CCRIS 635 CHEBI:64213 CHEMBL48449
    CS-4979 CTK8E0309 Cantharides
    Cantharides camphor Cantharides camphor, Cantharone Cantharone
    Caswell No. 157 DB12328 DHZBEENLJMYSHQ-XCVPVQRUSA-N
    EINECS 200-263-3 EPA Pesticide Chemical Code 013101 FCH3878399
    HMS2097B12 HMS3412J13 HMS3676J13
    HSDB 2181 HY-N0209 Hexahydro-3a,7-epoxyisobenzofuran-1,3-dione
    Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione Hexahydro-3aalpha,7aalpha-dimethyl-4beta,7beta-epoxyisobenzofuran-1,3-dione IGL471WQ8P
    Kantaridin Kantharidin Kantharidin [German]
    LS-98756 MFCD00134968 NCGC00016247-01
    NCGC00025212-02 NCGC00025212-03 NCGC00025212-04
    NCGC00025212-05 NCI60_005413 NCIMech_000301
    NSC 61805 NSC-61805 NSC61805
    Prestwick3_000885 PubChem6009 Q410884
    SC-05366 SCHEMBL152262 SR-01000597585
    SR-01000597585-1 UNII-IGL471WQ8P WLN: T C555 A AO DVOVTJ C1 G1
    X1105 ZINC17611186 cantharidin
    cid_6708701 exo-1,2-cis-Dimethyl-3,6-epoxyhexahydrophthalic anhydride exo-1,6-epoxyhexahydrophthalic anhydride

    DrugBank Name cantharidin
    DrugBank DB12328
    CAS Number 56-25-7, 57775-27-6
    PubChem Compound 5944
    KEGG Compound ID C16778
    KEGG Drug D11745
    ChEBI 64213