MITOTOX

Drug

D0848 | ciclesonide

Properties

Molecular Formula	C32H44O7
Molecular Weight	540.7
Structure
State	solid
Clearance	* 152 L/hr [Following IV administration of 800 mcg of ciclesonide]
Protein binding	The percentage of ciclesonide and des-ciclesonide bound to human plasma proteins averaged ≥ 99% each, with ≤ 1% of unbound drug detected in the systemic circulation.
Absorption	Ciclesonide and des-ciclesonide have negligible oral bioavailability (both less than 1%) due to low gastrointestinal absorption and high first-pass metabolism. The intranasal administration of ciclesonide at recommended doses results in negligible serum concentrations of ciclesonide.

Therapeutic Classification Source: DrugBank

R03BA08 Ciclesonide

[R03BA] Glucocorticoids

[R03B] OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS

[R03] DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES

[R] Respiratory system

R01AD13 Ciclesonide

[R01AD] Corticosteroids

[R01A] DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE

[R01] NASAL PREPARATIONS

[R] Respiratory system

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	7.91±1.38	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	15.45	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL		rat	hepatocytes	MMP assay	Negative	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 8 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H360 (25%): May damage fertility or the unborn child [Danger Reproductive toxicity] H361 (87.5%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H373 (25%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H413 (12.5%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P201, P202, P260, P273, P281, P308+P313, P314, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 8 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H360 (25%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H361 (87.5%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H373 (25%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H413 (12.5%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P201, P202, P260, P273, P281, P308+P313, P314, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

(11?,16?)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-pregna-1,4-diene-3,20-dione	(11?,16?)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione	(R)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate
126544-47-6	141845-82-1	2-((6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-cyclohexyl-7-hydroxy-6a,8a-dimethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-
2-oxoethyl isobutyrate	2H-Naphth (2',1':4,5) indeno (1,2-d) (1,3) dioxole, pregna-1,4-diene-3,20-dione deriv.;	544C476
AC-1330	AC1MIWNR	AKOS015994702
Alvesco	Alvesco (TN)	Alvesco 160
Alvesco 80	Alvesco HFA	Alvesco, Ciclesonide
B-9207-015	BDBM50247997	BI54903
BTR-15	BTR-15K	BY-9010
BYK-20426	C-23151	CAS-141845-82-1
CC-25775	CHEBI:31397	CHEMBL2040682
CS-2867	Ciclesonide	Ciclesonide (JAN/USAN/INN)
Ciclesonide [INN]	Ciclesonide [USAN:INN]	Ciclesonide, >=98% (HPLC)
Ciclesonide, European Pharmacopoeia (EP) Reference Standard	D01703	DB01410
DSSTox_CID_26659	DSSTox_GSID_46659	DSSTox_RID_81802
DTXSID9046659	GTPL7469	HMS3714N07
HY-B0625	KS-1165	LS-186047
LUKZNWIVRBCLON-GXOBDPJESA-N	NCGC00167484-01	NCGC00167972-01
O945	Omnair	Omnaris
Omnaris (TN)	Omnaris HFA	Osonase
Osonide	Pregna-1,4-diene-3,20-dione, 16,17-(((R)-cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha)-	Pregna-1,4-diene-3,20-dione, 16,17-((cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha(R))-
Q5119448	RPR 251526	RPR-251526
RPR251526	S59502J185	SCHEMBL3688
SR-01000942227	SR-01000942227-1	TBN-15
Tox21_112486	UNII-S59502J185	ZINC3915154
Zetonna	el-87-6	s4646

External IDs

DrugBank Name	ciclesonide
DrugBank	DB01410
CAS Number	126544-47-6, 141845-82-1
PubChem Compound	6918155
KEGG Drug	D01703
ChEBI	31397