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Drug

D0852 | clobetasol propionate

Molecular Formula C25H32ClFO5
Molecular Weight 467
Structure
State solid
Route of elimination Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids, including clobetasol propionate and its metabolites, are also excreted into the bile.
Absorption Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 24.64±1.67 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL human HepG2 MMP assay Negative IC50 163
MEMBRANE POTENTIAL 24.08±9.54 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 88 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H315 (34.09%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (34.09%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (32.95%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H360 (62.5%): May damage fertility or the unborn child [Danger Reproductive toxicity]


H373 (61.36%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


H413 (61.36%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P260, P261, P264, P271, P273, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (11b,16b)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11beta,16beta)-21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate 122C467
    21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11beta,16beta)- 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
    21-Chloro-9-fluoro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate 21-Chloro-9alpha-fluoro-11beta,17alpha-dihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17-Propionate 21-chloro-9-fluoro-11 beta-hydroxy-16 beta-methylpregna-1,4-diene-3,20-dione 17-propionate
    21-chloro-9-fluoro-11beta-hydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate 21-chloro-9-fluoro-11ss,17-dihydroxy-16ss-methylpregna-1,4-diene-3,20-dione 17-propionate 25122-46-7
    779619577M AB00383081-10 AB00383081_11
    AB1009262 AC-17990 AKOS015951278
    AMOT0927 AS-12555 BCP04125
    BCP0726000094 BCP9000539 BDBM39347
    BRD-K10799896-001-10-6 BRD-K10799896-001-26-2 Butavate
    C-22667 C25H32ClFO5 CAS-25122-46-7
    CC-25914 CCG-220781 CCI 4725
    CCI-4725 CCl 4725 CGP 9555
    CGP9555 CGP9555 pound>> CCl 4725 pound>>CGP 9555 pound>> CCl4725 pound>>CGP-9555 pound>> CCl-4725 CHEBI:31414
    CHEMBL1159650 CLOBETASOL PROPIONATE CLOBETASOL PROPIONATE (EMOLLIENT)
    CPD000058745 CS-2594 Certified Reference Material
    Clarelux Clobesol Clobestasol propionate
    Clobetasol 17-propionate Clobetasol Propionate, Pharmaceutical Secondary Standard Clobetasol for peak identification, European Pharmacopoeia (EP) Reference Standard
    Clobetasol propionate (JP17/USP) Clobetasol propionate E Clobetasol propionate [USAN:JAN]
    Clobetasol propionate [USAN:USP:JAN] Clobetasol propionate gel Clobetasol propionate, European Pharmacopoeia (EP) Reference Standard
    Clobetasol propionate, United States Pharmacopeia (USP) Reference Standard Clobetasol propionate, analytical standard Clobetasolpropionate
    Clobex Clobex (TN) Cormax
    Cormax (TN) D01272 DB01013
    DSSTox_CID_25907 DSSTox_GSID_45907 DSSTox_RID_81219
    DTXSID6045907 Dermoval Dermovate
    Dermoxinale EBD6220 EINECS 246-634-3
    Embeline Embeline E GR 2/925
    GTPL7062 HMS2090A04 HMS2230H08
    HMS3259A10 HMS3714M04 HY-13600
    Impoyz LS-118433 MFCD00058499
    MLS000028708 MLS001076345 NC00551
    NCGC00023373-03 NCGC00023373-04 NCGC00095078-01
    OLUX FOAM Olux (TN) Olux E
    Olux-E Opera_ID_1470 Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-methyl-, 17-propionate
    Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-methyl-,17-propionate; Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11beta,16beta)- Propionic acid clobetasol
    Q421637 SCHEMBL3997 SMR000058745
    SR-01000000280 SR-01000000280-4 Temovate
    Temovate E Tox21_111414 Tox21_111414_1
    UNII-779619577M Yugofin ZINC3977767
    [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate cid_32798 clobetasol 17-propanoate
    clobetasol-propionate s2584

    DrugBank Name clobetasol propionate
    DrugBank DB01013
    CAS Number 25122-41-2, 25122-46-7
    PubChem Compound 32798
    KEGG Drug D01272
    ChEBI 31414