D0857 | coumatetralyl
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 13.69±4.84 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 35.48 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 13.76±8.10 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
   |
Danger |
H300: Fatal if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H360D: May damage the unborn child [Danger Reproductive toxicity] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P352, P304+P340, P308+P313, P310, P312, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 43 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal] H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P262, P264, P270, P273, P280, P301+P310, P302+P350, P310, P314, P321, P322, P330, P361, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H300: Fatal if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H360D: May damage the unborn child [Danger Reproductive toxicity] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P352, P304+P340, P308+P313, P310, P312, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | oral | 50mg/kg (50mg/kg) | Defense des Vegetaux. Vol. 43(255-256), Pg. 20, 1989. | |
| guinea pig | LDLo | oral | 250mg/kg (250mg/kg) | "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971Vol. -, Pg. 115, 1971. | |
| rat | LD50 | oral | 30mg/kg (30mg/kg) | Farm Chemicals Handbook. Vol. -, Pg. C260, 1991. | |
| dog | LD50 | oral | 35mg/kg (35mg/kg) | Defense des Vegetaux. Vol. 43(255-256), Pg. 20, 1989. | |
| rabbit | LD50 | oral | 10mg/kg (10mg/kg) | Defense des Vegetaux. Vol. 43(255-256), Pg. 20, 1989. | |
| bird - domestic | LD50 | oral | 38300ug/kg (38.3mg/kg) | South African Journal for Enology and Viticulture. Vol. 7, Pg. 71, 1986. | |
| rat | LD50 | skin | 40mg/kg (40mg/kg) | Farm Chemicals Handbook. Vol. -, Pg. C260, 1991. | |
| chicken | LD50 | oral | > 3gm/kg (3000mg/kg) | Defense des Vegetaux. Vol. 43(255-256), Pg. 20, 1989. | |
| 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)- | 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)- (9CI) | 3-(.alpha.-Tetralinyl)-4-hydroxycoumarin |
| 3-(.alpha.-Tetralyl)-4-hydroxycoumarin | 3-(1,2,3,4-Tetrahydro-1-naphthyl)-4-hydroxycoumarin | 3-(1,2,3,4-Tetrahydro-1-naphthyl)-4-hydroxycoumarine |
| 3-(1,2,3,4-Tetrahydro-1-naphthyl)-4-hydroxycumarin | 3-(1,2,3,4-Tetrahydro-1-naphthyl)-4-hydroxycumarin [German] | 3-(1,2,3,4-Tetrahydro-1-naphtyl)-4-hydroxycoumarine |
| 3-(1,2,3,4-Tetrahydro-1-naphtyl)-4-hydroxycoumarine [French] | 3-(1-Tetralyl)-4-hydroxycoumarin | 3-(alpha-Tetral)-4-oxycoumarin |
| 3-(alpha-Tetralyl)-4-hydroxycoumarin | 3-(d-Tetralyl)-4-hydroxycoumarin | 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naftyl)-cumarine |
| 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naftyl)-cumarine [Dutch] | 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-1-benzopyran-2-one | 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-1-benzopyran-2-one (8CI)(9CI) |
| 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-1-benzopyran-2-one (8CI); | 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-chromen-2-one # | 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-cumarin |
| 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarin | 4-Hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-2H-1-benzopyran-2-one | 4-Idrossi-3-(1,2,3,4-tetraidro-1-naftil)-cumarina |
| 4-Idrossi-3-(1,2,3,4-tetraidro-1-naftil)-cumarina [Italian] | 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one | 5836-29-3 |
| AC-12689 | AKOS015903266 | BAY 25634 |
| BAY ene 11183 B | BRN 1323631 | Bayer 25 634 |
| C16806 | CAS-5836-29-3 | CCRIS 6923 |
| CHEBI:80742 | CHEMBL3184636 | COUMATETRALYL |
| Caswell No. 496A | Coumarin, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)- | Coumatetralyl [BSI:ISO] |
| Coumatetralyl, PESTANAL(R), analytical standard | Coumetralyl | Counmatetralyl |
| Cumatetralyl | Cumatetralyl [German, Dutch] | DSSTox_CID_21799 |
| DSSTox_GSID_41799 | DSSTox_RID_79847 | DTXSID8041799 |
| EINECS 227-424-0 | ENE 11183 B | EPA Pesticide Chemical Code 496100 |
| Endox | Endrocid | Endrocide |
| FT-0665202 | HSDB 1725 | LS-55246 |
| NCGC00255682-01 | Q415772 | Racumin |
| Raucumin 57 | Rodentin | SCHEMBL137261 |
| SCHEMBL5933927 | TR-020287 | Tox21_301252 |
| ULSLJYXHZDTLQK-UHFFFAOYSA-N |