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Drug

D0868 | deslanoside

Molecular Formula C47H74O19
Molecular Weight 943.1
Structure
State solid
Protein binding 0.2
Half life 36 hours
Absorption Little absorption from the gastrointestinal tract (40%).

C

C01AA07 Deslanoside


[C01AA] Digitalis glycosides


[C01A] CARDIAC GLYCOSIDES


[C01] CARDIAC THERAPY


[C] Cardiovascular system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 1.84±0.23 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 0.44 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]


H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]


H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


 P260, P264, P270, P271, P284, P301+P310, P304+P340, P310, P314, P320, P321, P330, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 intravenous 8100ug/kg (8.1mg/kg) Drugs in Japan Vol. 6, Pg. 489, 1982.
cat LD50 intravenous 230ug/kg (0.23mg/kg) "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 190, 1963.
mouse LD50 intraperitoneal 10360ug/kg (10.36mg/kg) Drugs in Japan Vol. 6, Pg. 489, 1982.


  • (3beta,5beta,12beta)-3-{[beta-D-glucopyranosyl-(1-->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide (3beta,5beta,12beta)-3-{[beta-D-glucopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide 17598-65-1
    3-[(O-beta-D-glucopyranosyl-(1-->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-3beta,5beta,12beta-card-20(22)-enolide; 3-[(O-beta-D-glucopyranosyl-(1->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-3beta,5beta,12beta-card-20(22)-enolide 3beta-(O-beta-D-Glucopyranosyl-(1-4)-O-beta-D-digitoxosyl-(1-4)-O-beta-D-digitoxosyl-(1-4)-beta-D-digitoxosyloxy-12beta,14-dihydroxy-5beta,14beta-card-20(22)-enolid
    3beta-(O-beta-D-Glucopyranosyl-(1-4)-O-beta-D-digitoxosyl-(1-4)-O-beta-D-digitoxosyl-(1-4)-beta-D-digitoxosyloxy=12beta.14=dihydroxy-5beta,14beta-card-20(22)-enolid 3beta-{[beta-D-glucopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12beta,14-dihydroxy-5beta-card-20(22)-enolide 4-18-00-02455 (Beilstein Handbook Reference)
    598D651 8100AH BRN 0078187
    C47H74O19 CAS-17598-65-1 CHEBI:31468
    CHEMBL1614 CS-0017480 Card-20(22)-enolide, 3-((O-beta-D-glucopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
    Card-20(22)-enolide, 3-((O-beta-D-glucopyranosyl-(1->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)- Cedilanid-D Cedilanid-d (TN)
    Cedilanide Ceglunat D01240
    DB01078 DSSTox_CID_2897 DSSTox_GSID_22897
    DSSTox_RID_76778 DTXSID1022897 Deacetyl-lanatoside C
    Deacetyllanatoside C Desace Desacetyl Lanatoside
    Desacetyl-Lanatoside C Desacetyldigilanide C Desacetyllanatoside C
    Deslanatoside C Deslanoside (JP17/USP/INN) Deslanoside [USAN:BAN:INN:JAN]
    Deslanoside [USP:INN:BAN:JAN] Deslanosido Deslanosido [INN-Spanish]
    Deslanosidum Deslanosidum C Deslanosidum [INN-Latin]
    EINECS 241-568-1 GTPL6806 HY-A0154
    LS-87553 Lanatoside C, deacetyl- Lekozid
    NCGC00159441-02 NCGC00159441-03 OBATZBGFDSVCJD-LALPQLPRSA-N
    Q5264583 SCHEMBL125311 Sediranido
    Tox21_111671 Tox21_111671_1 UNII-YGY317RK75
    YGY317RK75 ZINC253668332 deslanoside
    glucodigoxin

    DrugBank Name deslanoside
    DrugBank DB01078
    CAS Number 17598-65-1
    PubChem Compound 28620
    KEGG Compound ID C12669
    KEGG Drug D01240
    ChEBI 31468