Compound

D0871 | dexamethasone valerate

Molecular Formula C27H37FO6
Molecular Weight 476.6
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 12.06±4.39 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 17.34 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 23.46±5.67 rat hepatocytes MMP assay decrease IC50 163
MEMBRANE POTENTIAL > 200 µM 30 mins mouse liver mitochondria Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss) decrease EC20 36
RESPIRATION > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease EC20 36
RESPIRATION > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease EC20 36
SWELLING > 200 µM 30 mins mouse liver mitochondria swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling ) increase EC20 36

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. inhibit EC20 36
Succinate dehydrogenase > 200 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. inhibit EC20 36
Cytochrome c > 200 µM 30 mins mouse liver mitochondria Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline) release EC20 36

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H312 (33.33%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H361 (66.67%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H362 (33.33%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]


H373 (33.33%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P260, P263, P264, P270, P280, P281, P302+P352, P308+P313, P312, P314, P322, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LD50 subcutaneous 100mg/kg (100mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 subcutaneous 238mg/kg (238mg/kg) behavioral: muscle weakness Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 23, 1982.
rat LD50 subcutaneous 117mg/kg (117mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 oral > 3gm/kg (3000mg/kg) Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 23, 1982.
rat LD50 oral > 3gm/kg (3000mg/kg) Drugs in Japan Vol. -, Pg. 662, 1990.
mouse LD50 skin 1784mg/kg (1784mg/kg) Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 23, 1982.


  • 33755-46-3 9-Fluoro-11?,17,21-trihydroxy-16?-methyl-pregna-1,4-diene-3,20-dione 17-Valerate 9-Fluoro-11?,21-dihydroxy-16?-methyl-3,20-dioxopregna-1,4-dien-17-yl pentanoate ;DV 17
    9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17-valerate 9-fluoro-11ss,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate AKOS032429285
    Betamethasone Valerate EP Impurity C Betamethasone Valerate EP Impurity C; CAS-33755-46-3
    CHEBI:135770 CHEMBL1378167 D01948
    DSSTox_CID_2904 DSSTox_GSID_22904 DSSTox_RID_76782
    DTXSID3022904 DV-17 Dexamethasone 17-valerate
    Dexamethasone 17-valerate Dexamethasone Valarate Dexamethasone valerate
    Dexamethasone valerate (JAN) Dexamethasone valerate [JAN] EINECS 251-669-2
    LS-118480 MCULE-1282205271 NCGC00159316-02
    NCGC00274064-01 OI7CP949NN Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 17-valerate
    Q27285667 SCHEMBL124723 Tox21_111565
    Tox21_111565_1 UNII-OI7CP949NN Voalla ointment (TN)
    ZINC3882051

    CAS Number 33755-46-3
    PubChem Compound 63047
    KEGG Drug D01948
    ChEBI 135770