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Drug

D0873 | diacerein

Molecular Formula C19H12O8
Molecular Weight 368.3
Structure
Clearance Total CL is 1.5L/h and renal CL is 0.1L/h [A19300].
Volume of distribution 15-60L [A19300].
Route of elimination 37% excreted in urine and 53% in feces as estimated in rats [A19250].
Protein binding 99% of rhein is bound to plasma proteins [A19300].
Half life 4-10h [A19300].
Absorption Bioavailability of 50-60% [A19300]. Entirely converted to the active metabolite rhein [DB13174] before reaching systemic circulation.

M

M01AX21 Diacerein


[M01AX] Other antiinflammatory and antirheumatic agents, non-steroids


[M01A] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS


[M01] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS


[M] Musculoskeletal system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 20.64±8.26 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 17.34 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 14.17±11.27 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 59 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 2 of 59 companies. For more detailed information, please visit ECHA C&L website


Of the 4 notification(s) provided by 57 of 59 companies with hazard statement code(s):


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (98.25%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE 1,8-Diacetoxyanthraquinone-3-carboxylic acid 13739-02-1
    2-ANTHROIC ACID, 9,10-DIHYDRO-4,5-DIHYDROXY-9,10-DIOXO-, DIACETATE 2-Anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo- 2-Anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo- (9CI);
    3-10-00-04790 (Beilstein Handbook Reference) 4,5-Diacetoxy-9,10-dihydro-9,10-dioxo-2-anthrylcarbonsaeure 4,5-Diacetoxyanthraquinone-2-carboxylic Acid
    4,5-Diacetylrhein 4,5-bis(acetoxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid 4,5-bis(acetyloxy)-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
    4,5-diacetoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid 4,5-diacetoxy-9,10-diketo-anthracene-2-carboxylic acid 4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
    4,5-diacetyloxy-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid 4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid
    4HU6J11EL5 739D021 9,10-Dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylic acid
    9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid diacetate 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid, diacetate A807252
    AB00053327_14 AB0012779 AC-201
    AK468692 AKOS005622705 AM807992
    API0024493 ART 50 Artrodar
    B1726 BBL011075 BCP10834
    BDBM32018 BRN 2184909 C-21076
    C19H12O8 CAS-13739-02-1 CC-26418
    CCG-40287 CD0145 CHEBI:94708
    CHEMBL41286 CS-2880 D07270
    D4061 DB11994 DIACERIN
    DSSTox_CID_25636 DSSTox_GSID_45636 DSSTox_RID_81017
    DTXSID4045636 Diacerein Diacerein (USAN/INN)
    Diacerein [INN] Diacerein [USAN:INN] Diacerein, >=95% (HPLC)
    Diacerein, European Pharmacopoeia (EP) Reference Standard Diacereina Diacereina [Spanish]
    Diacereine Diacereine [French] Diacereinum
    Diacereinum [Latin] Diacerhein Diacetylrhein
    DivK1c_006739 EINECS 237-310-2 FT-0603096
    Fisiodar Gesamtmatrix HMS3652D06
    HMS3714B20 HY-N0283 K-4431
    KBio1_001683 KBio2_002395 KBio2_004963
    KBio2_007531 KBio3_001974 KBioGR_001591
    KBioSS_002400 KS-00000L24 KS-5088
    KW-4800 LS-20737 M-01AX21
    M01AX21 MCULE-3526700960 MFCD00468030
    MLS000028577 NCGC00018274-01 NCGC00018274-02
    NCGC00018274-03 NCGC00018274-04 NCGC00018274-05
    NCGC00022114-03 NSC-758147 NSC758147
    Pharmakon1600-01502010 Q413178 Rhein diacetate
    Rhein, diacetate Rhein, diacetate (6CI) SBI-0052833.P002
    SC-45485 SCHEMBL25784 SF-277
    SMR000058958 SPBio_000745 SPECTRUM1502010
    SR-01000003156 SR-01000003156-2 SR-01000003156-3
    SR-01000003156-4 STK802271 SW199355-2
    SpecPlus_000643 Spectrum2_000823 Spectrum3_000937
    Spectrum4_001036 Spectrum5_001819 Spectrum_001876
    TYNLGDBUJLVSMA-UHFFFAOYSA-N Tox21_110856 Tox21_110856_1
    UNII-4HU6J11EL5 W-108237 WHO 5371
    ZINC3812842 Zondar (TN) cid_26248
    s4267

    DrugBank Name diacerein
    DrugBank DB11994
    CAS Number 112118-18-0, 13739-02-1, 1391052-74-6
    PubChem Compound 26248
    KEGG Drug D07270
    ChEBI 94708