D0879 | dicofol
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 9.69±3.51 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 8.91 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 24.64±9.27 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Warning |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H315: Causes skin irritation [Warning Skin corrosion/irritation] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P312, P321, P322, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
Aggregated GHS information provided by 198 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P312, P321, P322, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H315: Causes skin irritation [Warning Skin corrosion/irritation] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P312, P321, P322, P330, P332+P313, P333+P313, P362, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
  |
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] |
P260, P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P309+P311, P310, P314, P321, P330, P333+P313, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | oral | 1810mg/kg (1810mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
| rat | LD50 | skin | 100mg/kg (100mg/kg) | World Review of Pest Control. Vol. 9, Pg. 119, 1970. | |
| mouse | LD50 | oral | 420mg/kg (420mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(9), Pg. 55, 1975. | |
| rabbit | LD50 | skin | 1870mg/kg (1870mg/kg) | Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 195, 1973. | |
| rat | LD50 | oral | 575mg/kg (575mg/kg) | World Review of Pest Control. Vol. 9, Pg. 119, 1970. | |
| women | TDLo | oral | 800uL/kg (0.8mL/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 1232, 1992. | |
| rabbit | LD50 | oral | 1810mg/kg (1810mg/kg) | behavioral: muscle contraction or spasticity) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 119, 1959. |
| rat | LD50 | intraperitoneal | 1150mg/kg (1150mg/kg) | Toxicology and Applied Pharmacology. Vol. 15, Pg. 30, 1969. | |
| rat | LC50 | inhalation | > 5gm/m3/4H (5000mg/m3) | Pesticide Manual. Vol. 9, Pg. 267, 1991. | |
| mammal (species unspecified) | LD50 | unreported | 433mg/kg (433mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(8), Pg. 101, 1973. | |
| chicken | LD50 | oral | 4365mg/kg (4365mg/kg) | Veterinariya. Veterinary Science. Vol. 60(10), Pg. 64, 1984. | |
| dog | LD50 | oral | 4gm/kg (4000mg/kg) | VM/SAC, Veterinary Medicine and Small Animal Clinician. Vol. 74, Pg. 1119, 1979. | |
| 1,1,1-Trichlor-2,2-bis(4-chlorphenyl)-aethanol | 1,1,1-Trichlor-2,2-bis(4-chlorphenyl)-aethanol [German] | 1,1-Bis(4-chlorophenyl)-2,2,2-trichloroethanol |
| 1,1-Bis(chlorophenyl)-2,2,2-trichloroethanol | 1,1-Bis(p-chlorophenyl)-2,2,2-trichloroethanol | 1,1-Bis-(p-chlorophenyl)-2,2,2-trichloroethanol |
| 1,1-bis-(chlorophenyl)-2,2,2-trichloroethanol | 115-32-2 | 115D322 |
| 2,2,2-Trichloor-1,1-bis(4-chloor fenyl)-ethanol | 2,2,2-Trichloor-1,1-bis(4-chloor-fenyl)-ethanol | 2,2,2-Trichloor-1,1-bis(4-chloor-fenyl)-ethanol [Dutch] |
| 2,2,2-Trichlor-1,1-bis(4-chlor-phenyl)-aethanol | 2,2,2-Trichlor-1,1-bis(4-chlor-phenyl)-aethanol [German] | 2,2,2-Trichloro-1,1-bis(4-chlorophenyl)-ethanol |
| 2,2,2-Trichloro-1,1-bis(4-chlorophenyl)-ethanol [French] | 2,2,2-Trichloro-1,1-bis(4-chlorophenyl)ethanol | 2,2,2-Trichloro-1,1-bis(4-cloro-fenil)-etanolo |
| 2,2,2-Trichloro-1,1-bis(4-cloro-fenil)-etanolo [Italian] | 2,2,2-Trichloro-1,1-bis(p-chlorophenyl)ethanol | 2,2,2-Trichloro-1,1-di(4-chlorophenyl)ethanol |
| 2,2,2-Trichloro-1,1-di-(4-chlorophenyl)ethanol | 2,2,2-trichloro-1,1-bis (4-chlorophenyl)ethanol | 2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethan-1-ol |
| 4,4'-Dichloro-.alpha.-(trichloromethyl)benzhydrol | 4,4'-Dichloro-alpha-(trichloromethyl)benzhydrol | 4-Chloro-.alpha.-(4-chlorophenyl)-.alpha.-(trichloromethyl)benzenemethanol |
| 4-Chloro-alpha-(4-chlorophenyl)-alpha-(trichloromethyl)benzenemethanol | 4-Chloro-alpha-(4-chlorophenyl)-alpha-(trichloromethyl)benzyl alcohol | AB1004845 |
| AGR0000029 | AI3-23648 | AKOS015903771 |
| Acarin | Agrothane | BIDD:ER0014 |
| BRN 1886299 | Benzenemethanol, 4-chloro-.alpha.-(4-chlorophenyl)-.alpha.-(trichloromethyl)- | Benzenemethanol, 4-chloro-alpha-(4-chlorophenyl)-alpha-(trichloromethyl)- |
| Benzhydrol, 4,4'-dichloro-.alpha.-(trichloromethyl)- | Benzhydrol, 4,4'-dichloro-alpha-(trichloromethyl)- | Bis(chlorophenyl)-2,2,2-trichl oroethanol |
| Bis(chlorophenyl)-2,2,2-trichloroethanol | C-21131 | C14301 |
| CAS-115-32-2 | CCRIS 231 | CHEBI:34692 |
| CHEMBL228511 | CPCA | Carbax |
| Carbox | Caswell No. 093 | Cekudifol |
| DB-041258 | DICOFOL | DSSTox_CID_450 |
| DSSTox_GSID_20450 | DSSTox_RID_75599 | DTMC |
| DTXSID4020450 | Decofol | Di-(p-chlorophenyl)trichloromethylcarbinol |
| Dichlorokelthane | Dicofol (kelthane) | Dicofol 10 microg/mL in Cyclohexane |
| Dicofol 10 microg/mL in Isooctane | Dicofol 100 microg/mL in Cyclohexane | Dicofol [BSI:ISO] |
| Dicofol solution, 100 mug/mL in methanol, PESTANAL(R), analytical standard | Dicofol, PESTANAL(R) | Dicofol, certified reference material, TraceCERT(R) |
| Dicomite | EINECS 204-082-0 | ENT 23,648 |
| Ethanol, 2,2,2-Trichloro-1,1-bis(4-chlorophenyl)- | Ethanol, 2,2,2-trichloro-1,1-bis(p-chlorophenyl)- | Ethanol,1,1-bis(p-chlorophenyl)-2,2,2-trichloro- |
| FT-0624733 | FW 293 | Fumite Dicofol |
| HSDB 631 | Hifol | Hilfol |
| Hilfol 18.5 ec | InChI=1/C14H9Cl5O/c15-11-5-1-9(2-6-11)13(20,14(17,18)19)10-3-7-12(16)8-4-10/h1-8,20H; | J-003282 |
| Keltane | Kelthane | Kelthane A |
| Kelthane dust base | Kelthanethanol | LS-575 |
| Mifol | Milbol | Mitigan |
| NCGC00091084-01 | NCGC00091084-02 | NCGC00091084-03 |
| NCGC00091084-04 | NCGC00254890-01 | NCI-C00486 |
| Q418183 | SCHEMBL26640 | Tox21_300988 |
| Tricofol | UNII-W4WMM0WS91 | UOAMTSKGCBMZTC-UHFFFAOYSA- |
| UOAMTSKGCBMZTC-UHFFFAOYSA-N | W4WMM0WS91 | ZINC2041041 |
| p,p'-Di cofol | p,p'-Dicofol | p,p'-Kelthane |
| p,p-Dicofol | para,para'-Kelthane |