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Drug

D0880 | dienestrol

Molecular Formula C18H18O2
Molecular Weight 266.3
Structure
State solid
Protein binding 50 to 80%
Absorption Systemic absorption and mode of action of dienestrol are undetermined.Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

G

G03CC02 Dienestrol


[G03CC] Estrogens, combinations with other drugs


[G03C] ESTROGENS


[G03] SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM


[G] Genitourinary system and reproductive hormones

G03CB01 Dienestrol


[G03CB] Synthetic estrogens, plain


[G03C] ESTROGENS


[G03] SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM


[G] Genitourinary system and reproductive hormones

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 10.93±1.88 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 8.3 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H350 (100%): May cause cancer [Danger Carcinogenicity]


H361 (97.44%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (E,E)-4,4'-(Diethylideneethylene)diphenol (E,E)-Dienestrol 13029-44-2
    2,4-Hexadiene, 3,4-bis(4-hydroxyphenyl)- 2375AH 3,4-Bis(4-hydroxyphenyl)-2,4-hexadiene
    3,4-Bis(p-hydroxyphenyl)-2,4-hexadiene 3,4-Bis(para-hydroxyphenyl)-2,4-hexadiene 4,4'-((2E,4E)-hexa-2,4-diene-3,4-diyl)diphenol
    4,4'-(1,2-Diethylidene-1,2-ethanediyl)bisphenol 4,4'-(2E,4E)-hexa-2,4-diene-3,4-diyldiphenol 4,4'-(Diethylideneethylene)diphenol
    4,4'-Dihydroxy-.gamma.,.delta.-diphenyl-.beta.,.delta.-hexadiene 4,4'-Dihydroxy-gamma,delta-diphenyl-beta,delta-hexadiene 4,4'-Hydroxy-gamma,delta-diphenyl-beta,delta-hexadiene
    4,4'-[(2E,4E)-2,4-Hexadiene-3,4-diyl]diphenol 4,4'-hexa-2,4-diene-3,4-diyldiphenol 4-[(2E,4E)-4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol
    4-[4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol 84-17-3 AB00051967_16
    AB2000337 AC-13162 AKOS015902490
    Agaldog BDBM40491 BPBio1_001030
    BRD-K55106630-001-01-0 BRD-K95309561-001-05-6 BRD-K95309561-001-15-5
    BSPBio_000936 BSPBio_002177 C08090
    CAS-84-17-3 CCG-40189 CCRIS 9121
    CHEBI:4518 CHEMBL1018 CS-4911
    Cycladiene D00898 D0449
    DB00890 DSSTox_CID_2382 DSSTox_GSID_22382
    DSSTox_RID_76566 DTXSID20873495 DV
    DV (TN) Dehydrostilbestrol Dehydrostilboestrol
    Di(p-oxyphenyl)-2,4-hexadiene Di(para-oxyphenyl)-2,4-hexadiene Dienesterol
    Dienestrol (E,E) Dienestrol (USP/INN) Dienestrol [INN]
    Dienestrol [USP:INN:BAN] Dienestrol(Restrol) Dienestrol, (E,E)-Isomer
    Dienestrol, European Pharmacopoeia (EP) Reference Standard Dienestrol, United States Pharmacopeia (USP) Reference Standard Dienestrol, VETRANAL(TM), analytical standard
    Dienestrolo Dienestrolo [DCIT] Dienestrolum
    Dienestrolum [INN-Latin] Dienoestrol Dienoestrol [Nonsteroidal oestrogens]
    Dienoestrol bp Dienol Dinestrol
    Dinovex E,E-Dienestrol EINECS 201-519-7
    Estragard Estraguard Estrodienol
    Estroral Follidiene Follormon
    GTPL7160 Gynefollin HMS1570O18
    HMS1920G04 HMS2091M14 HMS2097O18
    HMS2232M11 HMS3714O18 HMS502G13
    HSDB 3313 HY-B1403 Hormofemin
    IDI1_000771 J-005782 LS-104381
    MLS000069528 MLS001077274 MLS002207222
    MLS002222156 NCGC00016335-01 NCGC00018153-03
    NCGC00018153-04 NCGC00018153-05 NCGC00018153-06
    NCGC00018153-07 NCGC00018153-10 NCGC00022210-03
    NCGC00022210-04 NCGC00178779-01 NCGC00178779-02
    NFDFQCUYFHCNBW-SCGPFSFSSA-N NSC 59809 NSC-756734
    NSC756734 Oestrasid Oestrodiene
    Oestrodienol Oestroral Oestrovis
    Opera_ID_421 Pharmakon1600-01500241 Phenol, 4,4'-((1E,2E)-1,2-diethylidene-1,2-ethanediyl)bis-
    Phenol, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis- Phenol, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-, (E,E)- Phenol, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-, (E,E)- (9CI);
    Phenol, 4,4'-(diethylideneethylene)di- Phenol, 4,4'-(diethylideneethylene)di-, trans-, (E,E)- Prestwick2_000798
    Prestwick3_000798 Prestwick_52 Q5274949
    RRW32X4U1F Restrol Retalon
    SBI-0051344.P003 SCHEMBL2896853 SCHEMBL52170
    SMR000058597 SPECTRUM1500241 SR-01000003032
    SR-01000003032-2 SR-01000003032-4 Sexadien
    Spectrum5_000875 TR-026060 Teserene
    Tox21_110378 Tox21_110378_1 UNII-RRW32X4U1F
    Willnestrol ZINC1283 alpha-Dienestrol
    alpha-dienestrol diacetate cid_667476 dienestrol
    p,p'-(Diethylideneethylene)diphenol para,para'-(Diethylideneethylene)diphenol para-Dien
    s1858

    DrugBank Name dienestrol
    DrugBank DB00890
    CAS Number 13029-44-2, 35495-11-5, 84-17-3, 96056-51-8
    PubChem Compound 667476
    KEGG Compound ID C08090
    KEGG Drug D00898
    ChEBI 4518