Compound
D0882 | diflorasone diacetate
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 28.73±1.87 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | human | HepG2 | MMP assay | Negative | IC50 | 163 | ||
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Warning |
Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H312 (95.12%): Harmful in contact with skin [Warning Acute toxicity, dermal] H332 (92.68%): Harmful if inhaled [Warning Acute toxicity, inhalation] H351 (92.68%): Suspected of causing cancer [Warning Carcinogenicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P261, P271, P280, P281, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | subcutaneous | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. -, Pg. 487, 1990. | |
| rat | LD50 | intraperitoneal | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. -, Pg. 487, 1990. | |
| mouse | LD50 | oral | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. -, Pg. 487, 1990. | |
| rat | LD50 | oral | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. -, Pg. 487, 1990. | |
| mouse | LD50 | intraperitoneal | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. -, Pg. 487, 1990. | |
| mouse | LD50 | subcutaneous | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. -, Pg. 487, 1990. | |
| (6alpha,11beta,16beta)-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate | 33564-31-7 | 564D317 |
| 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-diacetate | 6alpha,9-difluoro-11beta-hydroxy-16beta-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate | 6alpha-Fluorobetamethasone-17,21 diacetate |
| 7W2J09SCWX | A821840 | AB00489907 |
| AB2000740 | AC-3515 | AKOS025402039 |
| Acetic acid diflorasone | Apexicon | Apexicon e |
| BCP9000608 | BOBLHFUVNSFZPJ-JOYXJVLSSA-N | BPBio1_000614 |
| BRD-K17674993-001-03-1 | BRN 2318163 | BSPBio_000558 |
| CAS-33564-31-7 | CCG-220619 | CHEBI:31483 |
| CHEMBL1200545 | CTK8F9190 | D01327 |
| DSSTox_CID_25646 | DSSTox_GSID_45646 | DSSTox_RID_81024 |
| DTXSID8045646 | Diflorasone di(acetate) | Diflorasone diacetate |
| Diflorasone diacetate (JP17/USP) | Diflorasone diacetate [USAN:JAN] | Diflorasone diacetate [USAN:USP:JAN] |
| Diflorasone diacetate, United States Pharmacopeia (USP) Reference Standard | EINECS 251-575-1 | FT-0639113 |
| Florone (TN) | Florone E | GTPL7068 |
| HMS1569L20 | HMS2096L20 | HMS2231D10 |
| HMS3713L20 | LS-118428 | MLS000069559 |
| MLS001076548 | NCGC00022003-03 | NCGC00022003-04 |
| NCGC00022003-06 | Opera_ID_1660 | Pregna-1,4-diene-3,20-dione, 17,21-bis(acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-, (6alpha,11beta,16beta)- |
| Pregna-1,4-diene-3,20-dione, 17,21-bis(acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-,(6-alpha,11-beta,16-beta)-; | Prestwick0_000619 | Prestwick1_000619 |
| Prestwick2_000619 | Prestwick3_000619 | Psorcon |
| Psorcon (TN) | Psorcon E | Q-101374 |
| Q27881705 | Q944 | REGID_for_CID_71414 |
| SC-80650 | SCHEMBL4556 | SMR000058814 |
| SPBio_002777 | SR-01000000122 | SR-01000000122-3 |
| Tox21_110875 | Tox21_110875_1 | U-34,865 |
| U-34865 | UNII-7W2J09SCWX | ZINC4212938 |
| [2-[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-acetyloxy-6,9-bis(fluoranyl)-10,13,16-trimethyl-11-oxidanyl-3-oxidanylidene-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxidanylidene-ethyl] ethanoate | [2-[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-acetyloxy-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate | acetic acid [2-[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-acetyloxy-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester |
| diflorasone 17,21-diacetate |