Drug
D0885 | dihydrotachysterol
A
A11CC02 Dihydrotachysterol
[A11CC] Vitamin D and analogues
[A11C] VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
[A11] VITAMINS
[A] Alimentary tract and metabolism
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 32.71±1.32 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | human | HepG2 | MMP assay | Negative | IC50 | 163 | ||
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Danger |
Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 288mg/kg (288mg/kg) | Drugs in Japan Vol. 6, Pg. 330, 1982. | |
| mouse | LD50 | intraperitoneal | 104mg/kg (104mg/kg) | Drugs in Japan Vol. 6, Pg. 330, 1982. | |
| (3S,5E,7E,10S,22E)-9,10-secoergosta-5,7,22-trien-3-ol | (5E,7E,22E)-(3S,10S)-9,10-seco-5,7,22-ergostatrien-3-ol | 67-96-9 |
| 9,10-Secoergosta-5,7,22-trien-3-ol, (3beta,5E,7E,10alpha,22E)- | 9,10-Secoergosta-5,7,22-trien-3beta-ol | A.T. 10 |
| AT 10 | Anti-tetany substance 10 | Antitanil |
| CAS-67-96-9 | CHEBI:4591 | CHEMBL2356023 |
| Calcamine | D00299 | DB01070 |
| DHT2 | DSSTox_CID_2938 | DSSTox_GSID_22938 |
| DSSTox_RID_76796 | DTXSID5022938 | Dht(sub 2) |
| Dichysterol | Dichystrolum | Dihidrotaquisterol |
| Dihidrotaquisterol [INN-Spanish] | Dihydral | Dihydrotachysterol (JAN/USP/INN) |
| Dihydrotachysterol [USP:INN:BAN:JAN] | Dihydrotachysterol(sub 2) | Dihydrotachysterolum |
| Dihydrotachysterolum [INN-Latin] | Diidrotachisterolo | Diidrotachisterolo [DCIT] |
| Dygratyl | EINECS 200-672-7 | HSDB 3314 |
| Hytakerol | Hytakerol (TN) | LMST03010056 |
| NCGC00166147-02 | Parterol | Q155685; |
| R5LM3H112R | SCHEMBL41340 | Tachyrol |
| Tachysterol, dihydro- | Tachysterol2, dihydro- | Tachystin |
| Tox21_112341 | UNII-R5LM3H112R | ZINC4212953 |
| dihydrotachysterol | dihydrotachysterol2 / (5E)-(10S)-10,19-dihydrovitamin D2 / (5E)-(10S)-10,19-dihydroergocalciferol |