D0893 | diphenoxylate hydrochloride
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 20.65±1.19 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 17.34 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 19.45±0.00 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
Aggregated GHS information provided by 92 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H300 (56.52%): Fatal if swallowed [Danger Acute toxicity, oral] H301 (43.48%): Toxic if swallowed [Danger Acute toxicity, oral] H310 (41.3%): Fatal in contact with skin [Danger Acute toxicity, dermal] H317 (42.39%): May cause an allergic skin reaction [Warning Sensitization, Skin] H330 (97.83%): Fatal if inhaled [Danger Acute toxicity, inhalation] H334 (42.39%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P261, P262, P264, P270, P271, P272, P280, P284, P285, P301+P310, P302+P350, P302+P352, P304+P340, P304+P341, P310, P320, P321, P322, P330, P333+P313, P342+P311, P361, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| 3810-80-8 | 4-Ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile, hydrochloride | 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride |
| AKOS027382491 | CAS-3810-80-8 | CCG-101002 |
| CHEBI:59784 | CHEMBL1200665 | CPD000469140 |
| D03860 | DSSTox_CID_27821 | DSSTox_GSID_47843 |
| DSSTox_RID_82584 | DTXSID3047843 | Diphenoxylate HCl |
| Diphenoxylate hydrochloride | Diphenoxylate hydrochloride (USP) | Diphenoxylate hydrochloride [USP] |
| Diphenoxylate hydrochloride cii | Diphenoxylate hydrochloride solution, 1.0 mg/mL in acetonitrile (as free base), ampule of 1 mL, certified reference material; | EINECS 223-287-6 |
| FT-0080160 | FT-0650835 | H507 |
| Isonipecotic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, hydrochloride | MLS001401383 | NC00252 |
| NCGC00167963-01 | NCGC00167963-02 | NCGC00167963-03 |
| Q-201004 | Q27126896 | R 1132 |
| R 1132 (antiperistaltic) | R-1132 (ANTIPERISTALTIC) | SAM001246532 |
| SCHEMBL42124 | SMR000469140 | Tox21_112593 |
| Tox21_112593_1 | Tox21_112825 | UNII-W24OD7YW48 |
| W24OD7YW48 | ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate hydrochloride | ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate;hydrochloride |