Search References Drug Actions/Targets About Access data Feedback
Sign In
[email protected]
2021 MitoTox | (CC BY-NC 4.0)
Compound

D0903 | doramapimod;bibr-796?

Molecular Formula C31H37N5O3
Molecular Weight 527.7
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 21.13±5.52 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 21.82 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 24.08±9.54 rat hepatocytes MMP assay decrease IC50 163


  • 1-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea
    1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3(4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl)urea 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
    1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea 1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
    1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea 1kv2 285983-48-4
    3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea 3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea 4CA-0473
    A819503 AB0033708 AC-24379
    AK-51367 AKOS005256489 AOB1672
    AS-19375 AX8126847 B96
    BCP01896 BCP9000416 BCPP000333
    BDBM13533 BIBR-796 BIRB 0796
    BIRB 796 BIRB 796 (Doramapimod) BIRB 796 BS
    BIRB 796,Doramapimod BIRB 796BS BIRB-0796
    BIRB-796 BIRB-796 BS BIRB-796, 3
    BIRB-796-(Doramapimod) BIRB796 BRD-K74065929-001-01-5
    C31H37N5O3 CAS-285983-48-4 CC1=CC=C(C=C1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=C(OCCN2CCOCC2)C=C1)C(C)(C)C
    CHEBI:40953 CHEMBL103667 CS-0219
    CTK8F0049 D03736 DB03044
    DSSTox_CID_28883 DSSTox_GSID_48957 DSSTox_RID_83151
    DTXSID2048957 Doramapimod Doramapimod (BIRB 796)
    Doramapimod (BIRB-796) Doramapimod (USAN/INN) Doramapimod [USAN:INN]
    Doramapimod, BIRB-796 FT-0667779 GTPL5668
    HMS3655C07 HMS3747G11 HO1A8B3YVV
    HY-10320 KIN0000097 KS-00000XIY
    KS-00001PQT Kinome_2137 MLS006010153
    MVCOAUNKQVWQHZ-UHFFFAOYSA-N N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]- N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-urea N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
    N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea; NCGC00241104-01 NCGC00241104-02
    NCGC00241104-07 PubChem18416 Q-101419
    Q27077098 RT-012412 S-7738
    SB16634 SC-19868 SCHEMBL129721
    SMR004458704 SR-00000002531 SR-00000002531-1
    ST2406821 SW219700-1 Tox21_113386
    Tox21_113386_1 UNII-HO1A8B3YVV US8933228, BIRB 796
    Urea, N-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-N'-(4-(2-(4-morpholinyl)ethoxy)-1-naphthalenyl)- Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]- X7401
    ZINC000024044436 ZINC24044436 cid_156422
    diaryl urea compound 10 s1574

    CAS Number 1283526-53-3, 285983-48-4
    PubChem Compound 156422
    ChEBI 40953