Compound
D0908 | endrin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 23.52±7.96 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 21.82 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Danger |
H300: Fatal if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P264, P270, P273, P280, P301+P310, P302+P352, P312, P321, P322, P330, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 162 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] H311 (97.53%): Toxic in contact with skin [Danger Acute toxicity, dermal] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P273, P280, P301+P310, P302+P352, P312, P321, P322, P330, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H300: Fatal if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P264, P270, P273, P280, P301+P310, P302+P352, P312, P321, P322, P330, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
H300: Fatal if swallowed [Danger Acute toxicity, oral] H310: Fatal in contact with skin [Danger Acute toxicity, dermal] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] |
P260, P262, P264, P270, P280, P301+P310, P302+P350, P307+P311, P310, P314, P321, P322, P330, P361, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| man | LDLo | oral | 171mg/kg (171mg/kg) | Human Toxicology. Vol. 4, Pg. 241, 1985. | |
| cat | LDLo | oral | 5mg/kg (5mg/kg) | Journal of Agricultural and Food Chemistry. Vol. 3, Pg. 842, 1955. | |
| hamster | LD50 | oral | 10mg/kg (10mg/kg) | Teratology, The International Journal of Abnormal Development. Vol. 9, Pg. 11, 1974. | |
| quail | LD50 | oral | 4210ug/kg (4.21mg/kg) | ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979. | |
| rat | LD50 | skin | 12mg/kg (12mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 13, 1978. | |
| bird - wild | LD50 | oral | 1780ug/kg (1.78mg/kg) | ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979. | |
| pigeon | LD50 | intravenous | 1500ug/kg (1.5mg/kg) | behavioral: convulsions or effect on seizure threshold | Toxicology and Applied Pharmacology. Vol. 9, Pg. 75, 1966. |
| mouse | LD50 | oral | 1370ug/kg (1.37mg/kg) | Toxicology and Applied Pharmacology. Vol. 25, Pg. 42, 1973. | |
| rabbit | LD50 | oral | 7mg/kg (7mg/kg) | Journal of Agricultural and Food Chemistry. Vol. 3, Pg. 842, 1955. | |
| pigeon | LD50 | oral | 5600ug/kg (5.6mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
| chicken | LDLo | oral | 2mg/kg (2mg/kg) | Canadian Veterinary Journal. Vol. 11, Pg. 74, 1970. | |
| rabbit | LD50 | skin | 60mg/kg (60mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 13, 1978. | |
| monkey | LD50 | oral | 3mg/kg (3mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 475, 1966. | |
| guinea pig | LD50 | oral | 16mg/kg (16mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 475, 1966. | |
| duck | LD50 | oral | 5330ug/kg (5.33mg/kg) | Toxicology and Applied Pharmacology. Vol. 22, Pg. 556, 1972. | |
| rabbit | LD50 | unreported | 7mg/kg (7mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 64, 1971. | |
| women | LDLo | oral | 234mg/kg (234mg/kg) | Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 22, Pg. 254, 1967. | |
| cat | LDLo | skin | 75mg/kg (75mg/kg) | Communicationes Veterinariae. Vol. 2, Pg. 71, 1958. | |
| mouse | LD50 | intravenous | 2300ug/kg (2.3mg/kg) | Toxicology and Applied Pharmacology. Vol. 23, Pg. 408, 1972. | |
| rat | LD50 | unreported | 17mg/kg (17mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 64, 1971. | |
| rat | LD50 | oral | 3mg/kg (3mg/kg) | World Review of Pest Control. Vol. 9, Pg. 119, 1970. | |
| mouse | LD50 | intracrebral | 400ug/kg (0.4mg/kg) | behavioral: convulsions or effect on seizure threshold | Toxicology Letters. Vol. 60, Pg. 289, 1992. |
| mouse | LD50 | intraperitoneal | 5mg/kg (5mg/kg) | Toxicology Letters. Vol. 60, Pg. 289, 1992. | |
| (1R,4S,4aS,5S,6S,7R,8R,8aR)-1,2,3,4,10,10-Hexachloro-1,4,4a,5,6,7,8,8a-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene | (1R,4S,5R,8S)-1,2,3,4,10,10-hexachloro-1,4, 4a,5,6,7,8,8a-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene | (1R,4S,5R,8S)-1,2,3,4,10,10-hexachloro-1,4,4a,5,6,7,8,8a-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene |
| (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphtho[2,3-b]oxirene | (1aalpha,2beta,2abeta,3alpha,6alpha,6abeta,7beta,7aalpha)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-Dimethanonaphth[2,3-b]oxirene | (1aalpha,2beta,2abeta,3alpha,6alpha,6abeta,7beta,7aalpha)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene |
| (3R,6S)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphtho[2,3-b]oxirene | 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A-OCTAHYDRO-ENDO,ENDO-,1,4:5,8-DIMETHANONAPHTHALENE | 1,2,3,4,10,10-Hexachloro-1R,4S,4aS,5S,6,7R,8R,8aR-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene |
| 1,2,3,4,10,10-Hexachloro-6,7-Epoxy-1,4,4a,5,6,7,8,8a-octahydro-exo-1,4-exo-5,8-dimethanonaphthalene | 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endo,endo-5,8-dimethanonaphthalene | 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo,endo-1,4:5,8-dimethanonaphthalene |
| 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo-1,4-endo-5,8-dimethanonaphthalene | 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8-dimethano-naphthalene | 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo,endo-1,4:5,8-dimethanonaphth alene |
| 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-, endo,endo- | 2,7:3,6-Dimethanonaphth(2,3-b)oxirane, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aalpha,2beta,3alpha,6alpha,6abeta,7beta, 7aalpha)- | 2,7:3,6-Dimethanonaphth(2,3-b)oxirane, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aalpha,2beta,3alpha,6alpha,6abeta,7beta,7aalpha)- |
| 2,7:3,6-Dimethanonaphth(2,3-b)oxirene, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-rel- | 2,7:3,6-Dimethanonaphth(2,3-b)oxirene, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aalpha,2beta,2abeta,3alpha,6alpha,6abeta,7beta,7aalpha)- | 2,7:3,6-Dimethanonaphth[2,3-b]oxirene, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1a.alpha.,2.beta.,2a.beta.,3.alpha.,6.alpha.,6a.beta.,7.beta.,7a.alpha.)- |
| 2,7:3,6-Dimethanonaphth[2,3-b]oxirene, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aI+/-,2I(2),2aI(2),3I+/-,6I+/-,6aI(2),7I(2),7aI+/-)- | 3,4,5,6,9,9-Hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene | 3,4,5,6,9,9-Hexachloro-1aalpha,2beta,2abeta,3alpha,6alpha,6abeta,7beta,7aalpha-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene |
| 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene, (1aA, 2B,2aB,3A,6A,6aB,7B,7aA)- | 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene, (1aA,2B,2aB,3A,6A,6aB,7B,7aA)-; | 4-17-00-00525 (Beilstein Handbook Reference) |
| 72-20-8 | AI3-17251 | BRN 0091397 |
| CAS-72-20-8 | CCRIS 276 | CHEMBL2356732 |
| Caswell No. 423 | Cmpd. 269 | Compound 269 |
| DFBKLUNHFCTMDC-GKRDHZSOSA-N | DSSTox_CID_561 | DSSTox_GSID_20561 |
| DSSTox_RID_75660 | DTXSID6020561 | EINECS 200-775-7 |
| EN 57 | ENDRIN | ENT 17,251 |
| EPA Pesticide Chemical Code 041601 | Endrex | Endricol |
| Endrin 1.6 EC | Endrin 10 microg/mL in Acetonitrile | Endrin 100 microg/mL in Isooctane |
| Endrin 20 EC | Endrin [ISO] | Endrin and metabolites |
| Endrin isomer | Endrin microg/mL in Cyclohexane | Endrin mixture |
| Endrine | Endrine [French] | Experimental insecticide 269 |
| HSDB 198 | Hexachloroepoxyoctahydro-endo,endo-dimethanonaphthalene | Hexachloroepoxyoctahydro-endo,endo-dimethanonapthalene |
| Hexadrin | LS-1613 | Latka 269 |
| Latka 269 [Czech] | Mendrin | NA 2761 |
| NCGC00091352-02 | NCGC00248106-01 | NCGC00254373-01 |
| NCI-C00157 | NSC 8935 | Nendrin |
| OB9NVE7YCL | OMS 197 | Oktanex |
| Q423354 | RCRA waste no. D013 | RCRA waste no. P051 |
| Rcra waste number P051 | SD 3419 | SD 3419 Illoxol |
| Stardrin | Stardrin 20 | Tox21_111120 |
| Tox21_300613 | UNII-OB9NVE7YCL | experimental insecticide no. 269 |
| rel-(1aR,2R,2aR,3R,6S,6aS,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth[2,3-b]oxirene |