Compound
D0912 | ergotamine d-tartrate
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 7.55±1.06 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | human | HepG2 | MMP assay | Negative | IC50 | 163 | ||
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
   |
Danger |
Aggregated GHS information provided by 49 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (85.71%): Toxic if swallowed [Danger Acute toxicity, oral] H302 (14.29%): Harmful if swallowed [Warning Acute toxicity, oral] H311 (85.71%): Toxic in contact with skin [Danger Acute toxicity, dermal] H331 (83.67%): Toxic if inhaled [Danger Acute toxicity, inhalation] H361 (91.84%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P261, P264, P270, P271, P280, P281, P301+P310, P301+P312, P302+P352, P304+P340, P308+P313, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | subcutaneous | 11mg/kg (11mg/kg) | Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften. Vol. 2, Pg. 1, 1946/1947. | |
| women | TDLo | oral | 11mg/kg/13W-I (11mg/kg) | vascular: bp elevation not characterized in autonomic section | Postgraduate Medical Journal. Vol. 61, Pg. 461, 1985. |
| mouse | LD50 | intraperitoneal | 412mg/kg (412mg/kg) | British UK Patent Application. Vol. #2025960, | |
| mouse | LD50 | intravenous | 62mg/kg (62mg/kg) | Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften. Vol. 2, Pg. 1, 1946/1947. | |
| man | TDLo | oral | 214ug/kg (0.214mg/kg) | behavioral: muscle contraction or spasticity) | Muenchener Medicinische Wochenschrift. Vol. 75, Pg. 736, 1928. |
| human | TDLo | oral | 3700ug/kg/26W (3.7mg/kg) | Headache. Vol. 18, Pg. 95, 1978. | |
| rabbit | LDLo | oral | 1mg/kg (1mg/kg) | Teratology, The International Journal of Abnormal Development. Vol. 7, Pg. 227, 1973. | |
| mouse | LDLo | oral | 300mg/kg (300mg/kg) | Teratology, The International Journal of Abnormal Development. Vol. 7, Pg. 227, 1973. | |
| rat | LD50 | intravenous | 80mg/kg (80mg/kg) | Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften. Vol. 2, Pg. 1, 1946/1947. | |
| women | TDLo | oral | 700ug/kg/14D- (0.7mg/kg) | British Journal of Clinical Practice. Vol. 49, Pg. 214, 1995. | |
| rat | LDLo | oral | 1mg/kg (1mg/kg) | Teratology, The International Journal of Abnormal Development. Vol. 7, Pg. 227, 1973. | |
| 379-79-3 | Avetol | CAS-379-79-3 |
| CCRIS 487 | CHEMBL2131781 | Cornutamin |
| DEA Code 8676 | DSSTox_CID_5253 | DSSTox_GSID_25253 |
| DSSTox_RID_77717 | DTXSID3025253 | EINECS 206-835-9 |
| ETIN | Ergam | Ergate |
| Ergomar | Ergostat | Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) (salt) |
| Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (2:1) (salt) | Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5alpha)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) | Ergotamine D-tartrate |
| Ergotamine D-tartrate, >=97.0% (calc. based on dry substance, NT) | Ergotamine D-tartrate, tested according to Ph.Eur. | Ergotamine bitartrate |
| Ergotamine hemitartrate | Ergotamine tartrate (2:1) (salt) | Ergotamine tartrate (VAN) |
| Ergotamine tartrate [USP:JAN] | Ergotamine tartrate, European Pharmacopoeia (EP) Reference Standard | Ergotamine tartrate, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 1313.41 ((C33H35N5O5)2 ?? C4H6O6); |
| Ergotamine, tartrate (2:1) | Ergotamine, tartrate (2:1) (salt) (8CI) | Ergotartrate |
| Exmigra | Femergin | Gotamine tartrate |
| Gynergen | Lingraine | Lingran |
| MRU5XH3B48 | Medihaler ergotamine | Migretamine |
| NCGC00091935-01 | NCGC00257225-01 | NCGC00259254-01 |
| NSC 41869 | Neo-ergotin | Q27284199 |
| Rigetamin | SCHEMBL134885 | Secagyn |
| Secupan | Telomerase Inhibitor IX and MST-312 | Tox21_111183 |
| Tox21_201705 | Tox21_303182 | UNII-MRU5XH3B48 |
| Wigrettes | ergotamine tartrate |
| CAS Number | 113-15-5, 368449-04-1, 379-79-3, 5469-04-5 |
| PubChem Compound | 9787 |