Compound
D0923 | ezetimibe
C
C10AX09 Ezetimibe
[C10AX] Other lipid modifying agents
[C10A] LIPID MODIFYING AGENTS, PLAIN
[C10] LIPID MODIFYING AGENTS
[C] Cardiovascular system
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 25.60±3.54 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 8.69 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 16.64±20.07 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 108 companies from 11 notifications to the ECHA C&L Inventory. H410 (83.33%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| (-)-Sch 58235 | (3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetidin-2-one | (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)- |
| (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one | (3R,4S)-1-(4-fluorophenyl)-3-[(3 S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one | (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)- 3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one |
| (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)azetidin-2-one | (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one | (3R,4S)-1-(p-Fluorophenyl)-3-((3S)-3-(p-fluorophenyl)-3-hydroxypropyl)-4-(p-hydroxyphenyl)-2-azetidinone |
| 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-(4-hydroxyphenyl)-2-azetidione | 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone | 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; |
| 163222-33-1 | 2-Azetidinone, 1-(4-fluorophenyl)-3-((3S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-, (3R,4S)- | 2-Azetidinone, 1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-, (3R-(3alpha(S*),4beta))- |
| 2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)- | 222E331 | 28055-EP2272841A1 |
| 28055-EP2280001A1 | 28055-EP2287165A2 | 28055-EP2287166A2 |
| 28055-EP2292620A2 | 28055-EP2294052A1 | 28055-EP2295422A2 |
| 28055-EP2298742A1 | 28055-EP2298769A1 | 28055-EP2298776A1 |
| 28055-EP2301923A1 | 28055-EP2301936A1 | 28055-EP2308878A2 |
| 28055-EP2314588A1 | 3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one | AB0011316 |
| AB00639916-06 | AB00639916-08 | AB00639916_09 |
| AB2000199 | ABP001091 | AC-1057 |
| ACT03511 | AKOS005572111 | AM84560 |
| AMX10142 | AR-270/43507897 | BDBM50371521 |
| BRD-K42260897-001-09-2 | C24H21F2NO3 | CAS-163222-33-1 |
| CCG-100884 | CHEBI:49040 | CHEMBL1138 |
| CPD000466334 | CS-1016 | Certified Reference Material |
| D01966 | DB00973 | DSSTox_CID_24223 |
| DSSTox_GSID_44223 | DSSTox_RID_80127 | DTXSID1044223 |
| EOR26LQQ24 | EX-A795 | Ezedoc |
| Ezetimibe | Ezetimibe (JAN/USAN/INN) | Ezetimibe (Zetia) |
| Ezetimibe [USAN:INN:BAN] | Ezetimibe [USAN:INN] | Ezetimibe(Zetia) |
| Ezetimibe, >=98% (HPLC) | Ezetimibe, Pharmaceutical Secondary Standard | Ezetimibe, United States Pharmacopeia (USP) Reference Standard |
| Ezetrol | FT-0601590 | GTPL6816 |
| HMS2051K16 | HMS2236A04 | HMS3715D06 |
| HSDB 7737 | HY-17376 | K-5098 |
| KS-1170 | LS-181801 | MCULE-4417284526 |
| MK-0653 | MK0653 | MLS000759443 |
| MLS001424125 | MLS006011921 | NC00134 |
| NCGC00095134-01 | NCGC00263575-01 | NCGC00263575-07 |
| OLNTVTPDXPETLC-XPWALMASSA-N | Q417997 | SAM001246623 |
| SC-17354 | SCH-58235 | SCH58235 |
| SCHEMBL2871 | SMR000466334 | STK640490 |
| Sch 58235 | Tox21_111443 | Tox21_111443_1 |
| UNII-EOR26LQQ24 | Z1550648770 | ZINC3810860 |
| Zetia | Zetia (TN) | Zetia ;Ezetrol |
| Zient | ezetimiba | ezetimibe anhydrate |
| ezetimibum | s1655 |