Compound

D0923 | ezetimibe

Molecular Formula C24H21F2NO3
Molecular Weight 409.4
Structure

C

C10AX09 Ezetimibe


[C10AX] Other lipid modifying agents


[C10A] LIPID MODIFYING AGENTS, PLAIN


[C10] LIPID MODIFYING AGENTS


[C] Cardiovascular system


Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 25.60±3.54 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 8.69 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 16.64±20.07 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 108 companies from 11 notifications to the ECHA C&L Inventory.


H410 (83.33%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (-)-Sch 58235 (3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetidin-2-one (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-
    (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one (3R,4S)-1-(4-fluorophenyl)-3-[(3 S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)- 3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
    (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)azetidin-2-one (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one (3R,4S)-1-(p-Fluorophenyl)-3-((3S)-3-(p-fluorophenyl)-3-hydroxypropyl)-4-(p-hydroxyphenyl)-2-azetidinone
    1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-(4-hydroxyphenyl)-2-azetidione 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone;
    163222-33-1 2-Azetidinone, 1-(4-fluorophenyl)-3-((3S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-, (3R,4S)- 2-Azetidinone, 1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-, (3R-(3alpha(S*),4beta))-
    2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)- 222E331 28055-EP2272841A1
    28055-EP2280001A1 28055-EP2287165A2 28055-EP2287166A2
    28055-EP2292620A2 28055-EP2294052A1 28055-EP2295422A2
    28055-EP2298742A1 28055-EP2298769A1 28055-EP2298776A1
    28055-EP2301923A1 28055-EP2301936A1 28055-EP2308878A2
    28055-EP2314588A1 3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one AB0011316
    AB00639916-06 AB00639916-08 AB00639916_09
    AB2000199 ABP001091 AC-1057
    ACT03511 AKOS005572111 AM84560
    AMX10142 AR-270/43507897 BDBM50371521
    BRD-K42260897-001-09-2 C24H21F2NO3 CAS-163222-33-1
    CCG-100884 CHEBI:49040 CHEMBL1138
    CPD000466334 CS-1016 Certified Reference Material
    D01966 DB00973 DSSTox_CID_24223
    DSSTox_GSID_44223 DSSTox_RID_80127 DTXSID1044223
    EOR26LQQ24 EX-A795 Ezedoc
    Ezetimibe Ezetimibe (JAN/USAN/INN) Ezetimibe (Zetia)
    Ezetimibe [USAN:INN:BAN] Ezetimibe [USAN:INN] Ezetimibe(Zetia)
    Ezetimibe, >=98% (HPLC) Ezetimibe, Pharmaceutical Secondary Standard Ezetimibe, United States Pharmacopeia (USP) Reference Standard
    Ezetrol FT-0601590 GTPL6816
    HMS2051K16 HMS2236A04 HMS3715D06
    HSDB 7737 HY-17376 K-5098
    KS-1170 LS-181801 MCULE-4417284526
    MK-0653 MK0653 MLS000759443
    MLS001424125 MLS006011921 NC00134
    NCGC00095134-01 NCGC00263575-01 NCGC00263575-07
    OLNTVTPDXPETLC-XPWALMASSA-N Q417997 SAM001246623
    SC-17354 SCH-58235 SCH58235
    SCHEMBL2871 SMR000466334 STK640490
    Sch 58235 Tox21_111443 Tox21_111443_1
    UNII-EOR26LQQ24 Z1550648770 ZINC3810860
    Zetia Zetia (TN) Zetia ;Ezetrol
    Zient ezetimiba ezetimibe anhydrate
    ezetimibum s1655

    CAS Number 163222-33-1
    PubChem Compound 150311
    ChEBI 49040