Compound
D0930 | fenretinide
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 3.40±0.76 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 4.89 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Danger |
Aggregated GHS information provided by 43 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (97.67%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (95.35%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (95.35%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (95.35%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (95.35%): Harmful if inhaled [Warning Acute toxicity, inhalation] H335 (93.02%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H360 (97.67%): May damage fertility or the unborn child [Danger Reproductive toxicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| women | TDLo | oral | 210mg/kg/2W-I (210mg/kg) | sense organs and special senses: "retinal changes (pigmentary depositions, retinitis, other): eye" | Archives of Ophthalmology Vol. 104, Pg. 69, 1986. |
| man | TDLo | oral | 180mg/kg/18D- (180mg/kg) | sense organs and special senses: "retinal changes (pigmentary depositions, retinitis, other): eye" | Archives of Ophthalmology Vol. 104, Pg. 69, 1986. |
| (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid (4-hydroxy-phenyl)-amide | (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenamide | (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7- |
| (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide | (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenamide | (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide |
| 1-enyl)nona-2,4,6,8-tetraenamide | 15-(4-Hydroxyanilino)retinal # | 15-[(4-hydroxyphenyl)amino]retinal |
| 187EJ7QEXL | 2,6,8-Nonatetraenamide, N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl-, (all-E)- | 3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid (4-hydroxy-phenyl)-amide |
| 33819-EP2275420A1 | 33819-EP2295055A2 | 33819-EP2295406A1 |
| 33819-EP2295416A2 | 33819-EP2295426A1 | 33819-EP2295427A1 |
| 33819-EP2298748A2 | 33819-EP2298764A1 | 33819-EP2298765A1 |
| 33819-EP2305642A2 | 33819-EP2311453A1 | 33819-EP2311808A1 |
| 33819-EP2311829A1 | 3670AH | 4 HPR |
| 4-(HYDROXYPHENYL)-RETINAMIDE (SEE RETINOID PROJECTS 1 AND 2.) | 4-(hydroxyphenyl)retinamide | 4-HPR |
| 4-HPR;(4-Hydroxyphenyl)retinamide | 4-Hydroxyphenyl retinamide | 4-hydroxy(phenyl)retinamide |
| 4-hydroxyphenylretinamide | 4HPR | 646F686 |
| 65646-68-6 | A12163 | A835178 |
| AB00172992-07 | AB0109574 | AKJHMTWEGVYYSE-FXILSDISSA-N |
| AKOS024456572 | AOB6402 | AS-59667 |
| BCP06908 | BDBM50092055 | BML2-E08 |
| BP-13369 | BRN 5769490 | BSPBio_001419 |
| CAS-65646-68-6 | CCG-204713 | CCRIS 3260 |
| CHEBI:42588 | CHEBI:92493 | CHEMBL7301 |
| CS-0789 | D04162 | DB05076 |
| DSSTox_CID_12005 | DSSTox_GSID_32005 | DSSTox_RID_78900 |
| DTXSID2032005 | EU-0100625 | FENRETINIDE |
| FT-0081247 | Fenretinida | Fenretinida [Spanish] |
| Fenretinide (4-HPR) | Fenretinide (USAN/INN) | Fenretinide [USAN:INN] |
| Fenretinidum | Fenretinidum [Latin] | Fenretinimide |
| H 7779 | HMS1361G21 | HMS1791G21 |
| HMS1989G21 | HMS2089B17 | HMS3261N12 |
| HMS3402G21 | HMS3412M06 | HMS3676M06 |
| HPR | HSCI1_000112 | HY-15373 |
| IDI1_033889 | LP00625 | LS-282 |
| Lopac0_000625 | MFCD00792674 | MK-4016 |
| MLS001055399 | MLS002701698 | MLS006010811 |
| McN-R-1967 | N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraeneamide; | N-(4-Hydroxyphenyl)-all-trans Retinamide |
| N-(4-Hydroxyphenyl)-trans-Retinamide | N-(4-Hydroxyphenyl)all-Trans Retinamide | N-(4-Hydroxyphenyl)retinamide |
| N-(4-hydroxyphenyl)-retinamide | N-(4-hydroxyphenyl)retinamide, 4-HPR | NCGC00090752-01 |
| NCGC00090752-02 | NCGC00090752-03 | NCGC00090752-04 |
| NCGC00090752-05 | NCGC00090752-06 | NCGC00090752-07 |
| NCGC00090752-09 | NCGC00090752-10 | NCGC00090752-11 |
| NCGC00090752-12 | NCGC00258542-01 | NCGC00261310-01 |
| NSC-374551 | NSC-760419 | NSC374551 |
| NSC760419 | Pharmakon1600-01505602 | Q5443576 |
| RETINOID PROJECT 2 (4-(HYDROXYPHENYL)RETINAMIDE) (SEE RETINOID PROJECT 1,3,4, 5,6) | RETINOID PROJECT 4 (4-HYDROXYPHENYL)RETINAMIDE (SEERETINOID PROJECT 1, 2, AND 3) | RETINOID PROJECT 5 (4-HYDROXYPHENYL)RETINAMIDE (SEERETINOID PROJECT 1, 2, 3, 4) |
| RETINOID PROJECT 6 (4-HPR) (SEE RETINOID PROJECTS 1,2,3,4,5) | Retinamide, N-(4-hydroxyphenyl)- | Retinoic acid p-hydroxyanilide |
| Retinoic acid p-hydroxyanilide, >=95% | Retinoic acid p-hydroxyphenylamide | SC-76490 |
| SCHEMBL11703 | SCHEMBL11704 | SCHEMBL15703189 |
| SMR000677938 | SMR001456303 | SR-01000075917 |
| SR-01000075917-1 | SR-01000075917-4 | ST-602 |
| SYT-101 | Spectrum5_001939 | Tox21_111007 |
| Tox21_111007_1 | Tox21_200989 | Tox21_500625 |
| UNII-187EJ7QEXL | W-5119 | ZINC3871023 |
| all-trans-4'-Hydroxyretinanilide | all-trans-n-(4-hydroxyphenyl)retinamide | dimethyl-9-(2,6,6-trimethylcyclohex- |
| p-Hydroxyphenylretinamide | s5233 |