Compound

D0930 | fenretinide

Molecular Formula C26H33NO2
Molecular Weight 391.5
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 3.40±0.76 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 4.89 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 43 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (97.67%): Harmful if swallowed [Warning Acute toxicity, oral]


H312 (95.35%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H315 (95.35%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (95.35%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H332 (95.35%): Harmful if inhaled [Warning Acute toxicity, inhalation]


H335 (93.02%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H360 (97.67%): May damage fertility or the unborn child [Danger Reproductive toxicity]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
women TDLo oral 210mg/kg/2W-I (210mg/kg) sense organs and special senses: "retinal changes (pigmentary depositions, retinitis, other): eye" Archives of Ophthalmology Vol. 104, Pg. 69, 1986.
man TDLo oral 180mg/kg/18D- (180mg/kg) sense organs and special senses: "retinal changes (pigmentary depositions, retinitis, other): eye" Archives of Ophthalmology Vol. 104, Pg. 69, 1986.


  • (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid (4-hydroxy-phenyl)-amide (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenamide (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-
    (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenamide (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide
    1-enyl)nona-2,4,6,8-tetraenamide 15-(4-Hydroxyanilino)retinal # 15-[(4-hydroxyphenyl)amino]retinal
    187EJ7QEXL 2,6,8-Nonatetraenamide, N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl-, (all-E)- 3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid (4-hydroxy-phenyl)-amide
    33819-EP2275420A1 33819-EP2295055A2 33819-EP2295406A1
    33819-EP2295416A2 33819-EP2295426A1 33819-EP2295427A1
    33819-EP2298748A2 33819-EP2298764A1 33819-EP2298765A1
    33819-EP2305642A2 33819-EP2311453A1 33819-EP2311808A1
    33819-EP2311829A1 3670AH 4 HPR
    4-(HYDROXYPHENYL)-RETINAMIDE (SEE RETINOID PROJECTS 1 AND 2.) 4-(hydroxyphenyl)retinamide 4-HPR
    4-HPR;(4-Hydroxyphenyl)retinamide 4-Hydroxyphenyl retinamide 4-hydroxy(phenyl)retinamide
    4-hydroxyphenylretinamide 4HPR 646F686
    65646-68-6 A12163 A835178
    AB00172992-07 AB0109574 AKJHMTWEGVYYSE-FXILSDISSA-N
    AKOS024456572 AOB6402 AS-59667
    BCP06908 BDBM50092055 BML2-E08
    BP-13369 BRN 5769490 BSPBio_001419
    CAS-65646-68-6 CCG-204713 CCRIS 3260
    CHEBI:42588 CHEBI:92493 CHEMBL7301
    CS-0789 D04162 DB05076
    DSSTox_CID_12005 DSSTox_GSID_32005 DSSTox_RID_78900
    DTXSID2032005 EU-0100625 FENRETINIDE
    FT-0081247 Fenretinida Fenretinida [Spanish]
    Fenretinide (4-HPR) Fenretinide (USAN/INN) Fenretinide [USAN:INN]
    Fenretinidum Fenretinidum [Latin] Fenretinimide
    H 7779 HMS1361G21 HMS1791G21
    HMS1989G21 HMS2089B17 HMS3261N12
    HMS3402G21 HMS3412M06 HMS3676M06
    HPR HSCI1_000112 HY-15373
    IDI1_033889 LP00625 LS-282
    Lopac0_000625 MFCD00792674 MK-4016
    MLS001055399 MLS002701698 MLS006010811
    McN-R-1967 N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraeneamide; N-(4-Hydroxyphenyl)-all-trans Retinamide
    N-(4-Hydroxyphenyl)-trans-Retinamide N-(4-Hydroxyphenyl)all-Trans Retinamide N-(4-Hydroxyphenyl)retinamide
    N-(4-hydroxyphenyl)-retinamide N-(4-hydroxyphenyl)retinamide, 4-HPR NCGC00090752-01
    NCGC00090752-02 NCGC00090752-03 NCGC00090752-04
    NCGC00090752-05 NCGC00090752-06 NCGC00090752-07
    NCGC00090752-09 NCGC00090752-10 NCGC00090752-11
    NCGC00090752-12 NCGC00258542-01 NCGC00261310-01
    NSC-374551 NSC-760419 NSC374551
    NSC760419 Pharmakon1600-01505602 Q5443576
    RETINOID PROJECT 2 (4-(HYDROXYPHENYL)RETINAMIDE) (SEE RETINOID PROJECT 1,3,4, 5,6) RETINOID PROJECT 4 (4-HYDROXYPHENYL)RETINAMIDE (SEERETINOID PROJECT 1, 2, AND 3) RETINOID PROJECT 5 (4-HYDROXYPHENYL)RETINAMIDE (SEERETINOID PROJECT 1, 2, 3, 4)
    RETINOID PROJECT 6 (4-HPR) (SEE RETINOID PROJECTS 1,2,3,4,5) Retinamide, N-(4-hydroxyphenyl)- Retinoic acid p-hydroxyanilide
    Retinoic acid p-hydroxyanilide, >=95% Retinoic acid p-hydroxyphenylamide SC-76490
    SCHEMBL11703 SCHEMBL11704 SCHEMBL15703189
    SMR000677938 SMR001456303 SR-01000075917
    SR-01000075917-1 SR-01000075917-4 ST-602
    SYT-101 Spectrum5_001939 Tox21_111007
    Tox21_111007_1 Tox21_200989 Tox21_500625
    UNII-187EJ7QEXL W-5119 ZINC3871023
    all-trans-4'-Hydroxyretinanilide all-trans-n-(4-hydroxyphenyl)retinamide dimethyl-9-(2,6,6-trimethylcyclohex-
    p-Hydroxyphenylretinamide s5233

    CAS Number 65646-68-6
    PubChem Compound 5288209
    ChEBI 42588